Hypotensive tablet containing sodium chloride medicine carrier
A sodium chloride and blood pressure lowering technology, applied in the field of medicine, can solve the problems of degradation, affecting the stability of candesartan cilexetil, and unsuitable use of excipients, etc., and achieve the effects of fast release, inhibition of crystal disorder, and excellent compressibility
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Embodiment 1
[0015] Example 1 Preparation of candesartan cilexetil tablets
[0016] 1. Recipe: See Table 1
[0017] Table 1 Formula of candesartan cilexetil tablets (1000 tablets, unit: g)
[0018]
[0019] 2. Preparation:
[0020] 1) Weigh polyethylene glycol 6000 according to the proportion of the formula, heat up to 70~75°C, and melt into a liquid ( ).
[0021] 2) Weigh candesartan cilexetil, sodium chloride, and croscarmellose sodium (or carboxymethyl starch sodium) according to the ratio of the formula, mix them evenly, add them into the turbo granulator, turn on the turbo granulator, and control The inlet air temperature keeps the material temperature at 25~40°C, and the ( ) is slowly sprayed onto the material by air-flow atomization, discharges the material after spraying, and granulates to obtain candesartan cilexetil granules ( ).
[0022] 3) take magnesium stearate and ( ) mixed evenly, at 15kN / cm 2 The following pressure tablet.
Embodiment 2
[0023] Example 2 Preparation of candesartan cilexetil tablets
[0024] 1. Formula: see Table 2
[0025] Table 2 Formula of candesartan cilexetil tablets (1000 tablets, unit: g)
[0026]
[0027] 2. Preparation Process:
[0028] 1) Weigh polyethylene glycol 8000 according to the proportion of the formula, heat up to 70~80°C, and melt into a liquid ( ).
[0029] 2) Weigh candesartan cilexetil, sodium chloride, and croscarmellose sodium (or carboxymethyl starch sodium) according to the ratio of the formula, mix them evenly, add them into the turbo granulator, turn on the turbo granulator, and control The inlet air temperature keeps the material temperature at 25~40°C, and the ( ) is slowly sprayed onto the material by air-flow atomization, discharges the material after spraying, and granulates to obtain candesartan cilexetil granules ( ).
[0030] 3) take magnesium stearate and ( ) mixed evenly, at 15kN / cm 2 The following pressure tablet.
[0031] Compa...
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