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Particle for treating cardio-cerebrovascular disease, and tis preparing and active constituent content measuring method

A technology for cardiovascular and cerebrovascular diseases and active ingredients, which is applied in cardiovascular system diseases, medical preparations containing active ingredients, plant/algae/fungus/moss ingredients, etc. and bioavailability

Inactive Publication Date: 2006-08-09
SICHUAN GUOKANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] However, due to the reasons of the preparation technology itself, the existing dosage forms such as Naoxinqing tablets and capsules have long dissolution time and low dissolution rate, which affect their absorption and bioavailability and other indicators, thereby affecting the drug efficacy. play, even therapeutic effect

Method used

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  • Particle for treating cardio-cerebrovascular disease, and tis preparing and active constituent content measuring method
  • Particle for treating cardio-cerebrovascular disease, and tis preparing and active constituent content measuring method
  • Particle for treating cardio-cerebrovascular disease, and tis preparing and active constituent content measuring method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0154] Take dried persimmon leaves, add water and decoct twice, the first time for 2 hours, the second time for 1 hour, add 12 times the amount of water each time, combine the decoction, filter, and concentrate the filtrate to a relative density of 1.12-1.15 (60°C) , add ethanol until the alcohol content reaches 85%, let it stand overnight, and filter the supernatant for later use; wash the precipitate twice with 65% ethanol, collect the washing liquid, let it stand, absorb the supernatant and combine it with the previous supernatant, and recover Ethanol, the obtained extract is dissolved in water, filtered, the filtrate is extracted four times with ethyl acetate, the ethyl acetate solution is combined, ethyl acetate is recovered, the thick paste is dried at low temperature into a dry extract, and sucrose and paste are added for every 33.4g dry extract Essence 970g (sucrose: dextrin = 25: 4), mix evenly, use 35% ethanol in an appropriate amount, make granules, dry at low temper...

Embodiment 2

[0156] 150g of dry extract of persimmon leaf ethyl acetate extract obtained by the above method, add 2000g of dextrin and appropriate amount of stevioside flavoring agent, mix well, use appropriate amount of 30% ethanol, granulate, dry at low temperature, and granulate to obtain brain Xinqing sugar-free granules.

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Abstract

The present invention relates to a persimmon leaf extract granules preparation, its preparation and effective component content determination method. Its name is Naoxinqing granules preparation, and is an oral medicine preparation for curing the diseases of coronary heart disease, angina pectoris, cerebral arteriosclerosis and ischemic cerebrovascular disease, etc.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine. It relates to a Naoxinqing granule for cardiovascular and cerebrovascular diseases and its preparation and effective component content determination method, in particular to the preparation of the extract containing the active component of the traditional Chinese medicine persimmon leaf as a raw material together with suitable pharmaceutically acceptable excipients A pharmaceutical composition oral preparation. Background technique [0002] Naoxinqing Tablet is an oral preparation made from the traditional Chinese medicine persimmon leaves after extraction and processing. Its standard comes from the drug standard WS of the Ministry of Health. 3 -B-3974-98. It can increase the blood flow of coronary and cerebral arteries, improve the blood and oxygen supply status of heart and brain tissue, and increase the electrophoretic rate of red blood cells. It is used to treat angina ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/44A61K9/16A61P9/10G01N30/02
Inventor 冀广沁陈家伟石万棋支春左治国李先楞万玲徐琨
Owner SICHUAN GUOKANG PHARMA
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