Naphthalene-containing melanocortin receptor-specific small molecule

A compound and stereoisomer technology, applied in the field of 3/061660, can solve the problems of not disclosing the structure of a single substituent, not disclosing the structure of piperazine, etc.
CN1816337AInactive Publication Date: 2006-08-09PALATIN TECH INC
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
PALATIN TECH INC
Publication Date
2006-08-09
Estimated Expiration
Not applicable · inactive patent

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Abstract

A melanocortin receptor-specific compound of the general formula of structure I: where X, R1, R2a, R2b, R3, R4a, R4b, R5a and R5b are as defined in the specification, which compound binds with high affinity to one or more melanocortin receptors and is optionally an agonist, an antagonist, an inverse agonist or an antagonist of an inverse agonist, and may be employed for treatment of one or melanocortin receptor-associated conditions or disorders, and methods for the use of the compounds of the invention.
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Description

Background of the invention

[0001] Field of invention (technical field):

[0002] The present invention relates to tetra- and penta-substituted piperazines and piperazine-derived ring compounds, optionally containing C=O or C=S units, which bind one or more melanocortin receptors body and is optionally an agonist, antagonist, mixed agonist-antagonist or inverse agonist for one or more melanocortin receptors and is useful in the treatment of metabolic, immune, infection-related and melanocortin receptor-mediated diseases.

[0003] Related prior art:

[0004] Note that the following discussion refers to documents by a number of authors and years of origin, as well as their most recent publication dates, some of which are not considered prior art to the present invention. The discussion of these documents provides a more complete technical background and should not be construed as prior art for purposes of determining patentability.

[0005] Piperazines are an important class...

Claims

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