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Use of rhubarb anthraquinone compound in preventing and treating influenza virus infectious disease

A technology for infectious diseases and influenza viruses, which is applied in the application field of rhubarb anthraquinone compounds in the prevention and treatment of influenza virus infectious diseases, and can solve the problems of easy damage to host cells, soft or loose stools, drug-resistant strains, etc. Achieve the effect of strong anti-influenza virus effect, less toxic and side effects, and rich natural resources

Inactive Publication Date: 2006-10-11
GUILIN MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are many anti-influenza virus drugs in clinical use, but most of them are highly toxic, easily damage host cells and easily lead to the emergence of drug-resistant strains
Currently, ribavirin has the best therapeutic effect, but it also has certain side effects. A small number of patients have symptoms such as dry mouth, soft or loose stools, and leukopenia when taking oral or intravenous injection. Animal experiments have carcinogenic effects. disabled

Method used

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  • Use of rhubarb anthraquinone compound in preventing and treating influenza virus infectious disease

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Example 1: Rhubarb anthraquinone compounds are made into injection rhubarb injection, the total anthraquinone content of rhubarb is 100mg / ml, each 2.0ml, clinically used to prevent and treat diseases caused by influenza virus, usage: 2.0ml each time, intramuscular injection , intravenous injection or intravenous drip, 2 times a day, 5 days a course of treatment.

Embodiment 2

[0029] Example 2: rhubarb anthraquinone compounds were made into rhubarb tablets, the total anthraquinone content of rhubarb was 200mg / 0.5g / tablet, which was clinically used to prevent and treat diseases caused by influenza virus. Usage 2-4 tablets each time, orally, 2-3 times a day, 7 days as a course of treatment.

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Abstract

The invention relates to an application of anthraquinones compound in preventing diseases infected by influenza virus. The median poison concentration TC50 of anthraquinones compound for cell MDCK is 226.1 ug / ml, the comparison is 351.3 ug / ml; the median effective concentration LC50 for influenza virus is122.4 ug / ml, the comparison is 62.7 ug / ml; and the treating index is 1.9. It is proved that the inhibiting rate for influenza virus is increased with increased drug concentration. The side effect of nthraquinones compound is smaller than that of ribavirin, the process is simple and it can be prepared into various dosage forms.

Description

(1) Technical field: [0001] The present invention relates to the application of rhubarb anthraquinone compounds, specifically the application of rhubarb anthraquinone compounds in the prevention and treatment of influenza virus infectious diseases (two) background technology: [0002] Influenza is an acute viral respiratory infectious disease caused by influenza virus, characterized by high incidence, widespread prevalence and rapid spread. At present, there are many anti-influenza virus drugs in clinical use, but most of them are highly toxic, easily damage host cells and easily lead to the emergence of drug-resistant strains. Currently, ribavirin has the best therapeutic effect, but it also has certain side effects. A small number of patients have symptoms such as dry mouth, soft or loose stools, and leukopenia when taking oral or intravenous injection. Animal experiments have carcinogenic effects. disabled. (3) Contents of the invention: [0003] The purpose of the pr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/122A61K9/08A61K9/20A61P31/16
Inventor 罗伟生徐庆张奉学苏小建刘卫兵唐祖年梁荣感李丽亚韦京辰
Owner GUILIN MEDICAL UNIVERSITY
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