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Medicine composition for treating cervical spondylosis and its preparing method

A composition and technology for cervical spondylosis, applied in the field of pharmaceutical compositions for the treatment of cervical spondylosis, can solve the problems of drugs and pharmaceutical preparations for treating cervical spondylosis, and achieve the effect of clear drug effect, strong controllability and stable quality

Inactive Publication Date: 2011-01-19
谢秀琼
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] At present, it has been reported in the literature that a large group of prescriptions containing Chuanxiong and Pueraria root can treat cervical spondylosis, and there are also reports of treating cervical spondylosis with Chuanxiong or Pueraria alone. There is no report on the combination of the two drugs. There are no effective drugs and pharmaceutical preparations for the treatment of cervical spondylosis and can achieve the effect of continuous administration

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] The extraction of embodiment 1 pharmaceutical raw material of the present invention

[0038] a, the preparation of Rhizoma Chuanxiong alkaloid: get the coarse powder of Rhizoma Chuanxiong medicinal material, soak, percolate with pH value 2~3 acid water, in per Kg medicinal material, percolation rate is 4~5ml / min, collect percolation liquid, pass through large Porous adsorption resin, the eluent passes through the strong acidic cation exchange resin, elutes with a certain concentration of hydrochloric acid, collects the eluent, concentrates, the concentrated solution passes through the macroporous adsorption resin, collects the column liquid, and dries to obtain the total alkaloids of Ligusticum chuanxiong ;

[0039] b. Preparation of total flavonoids of Pueraria lobata: take Pueraria lobata, extract with reflux of 50% ethanol, recover ethanol from the ethanol extract under reduced pressure, filter, pass through an adsorption resin column, elute with 70% ethanol, collect...

Embodiment 2

[0040] The extraction of embodiment 2 pharmaceutical raw materials of the present invention

[0041] a. Chuanxiong alkaloids: take the coarse powder of Chuanxiong medicinal materials, soak and percolate with acid water with a pH value of 3, based on each Kg of medicinal materials, the percolation rate is 5ml / min, collect the percolating liquid, pass through the macroporous adsorption resin, and elute The solution is then passed through a strong acidic cation exchange resin, eluted with a certain concentration of hydrochloric acid, the eluate is collected, concentrated, the concentrated solution is passed through a macroporous adsorption resin, the column liquid is collected, and dried to obtain the total alkaloids of Rhizoma Chuanxiong;

[0042] b. Total flavonoids of kudzu root: take kudzu root, reflux extraction with 50% ethanol, recover ethanol from the ethanol extract under reduced pressure, filter, pass through an adsorption resin column, elute with 30% ethanol, collect th...

Embodiment 3

[0043] Embodiment 3 Extraction of pharmaceutical raw materials of the present invention

[0044] a. Chuanxiong alkaloids: take the coarse powder of Chuanxiong medicinal materials, soak and percolate with acid water with a pH value of 2, in terms of each Kg of medicinal materials, the percolation rate is 4ml / min, collect the percolating liquid, pass through the macroporous adsorption resin, and elute The solution is then passed through a strong acidic cation exchange resin, eluted with hydrochloric acid, the eluate is collected, concentrated, the concentrated solution is passed through a macroporous adsorption resin, the column liquid is collected, and dried to obtain the total alkaloids of Rhizoma Chuanxiong;

[0045] b. Total flavonoids of kudzu root: take kudzu root, reflux extraction with 90% ethanol, recover ethanol from the ethanol extract under reduced pressure, filter, pass through an adsorption resin column, elute with 90% ethanol, collect ethanol eluate, recycle ethano...

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Abstract

The cervical spondylosis treating medicine composition is prepared with Chuanxiong rhizome and kudzu vine root as material, or compounded with Chuanxiong alkaloid and pueraria flavonid as main components. The present invention also provides the preparation process of the medicine composition. The medicine composition has the synergistic effect of Chuanxiong rhizome and kudzu vine root or Chuanxiong alkaloid and pueraria flavonid, determined curative effect, stable quality and excellent controllability.

Description

technical field [0001] The invention relates to a pharmaceutical composition for treating cervical spondylosis, in particular, it is prepared from Rhizoma Chuanxiong and Radix Puerariae as raw materials. Background technique [0002] Vertebral artery cervical spondylosis (also known as cervical vertigo) is the most complicated type of cervical spondylosis. According to its clinical manifestations, vertigo is the main feature, and it belongs to the category of "vertigo" in traditional Chinese medicine. It is a common disease and frequently-occurring disease in middle-aged and elderly people, usually over 45 years old, more common in 50-60 years old, and the incidence rate has a parallel upward trend with age, and the symptoms are also aggravated day by day with age. The occurrence of vertebral artery type cervical spondylosis is mainly due to slow blood flow, insufficient blood supply, or even interruption of blood flow caused by compression, stimulation, blood stasis or vert...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/16A61K36/488A61P19/08A61K9/48A61K9/20
Inventor 谢秀琼王曙宾罗海燕
Owner 谢秀琼