The invention relates to an artificial soil layer quick infiltration system and method for removing ethinylestradiol in water with high hydraulic load, and the main structure of the system adopts an organic glass column as a carrier. Overall height of the column is 55cm, including overflow space with a height of 10 cm and dense filling of artificial mixed soil and gravel filter materials with a height of 45 cm. Fillers, from top to bottom, include a mixture of silty clay, medium-fine sand and volcanic rocks with a thickness of 15 cm, zeolite with a thickness of 25 cm, and coarse sandy gravel with a thickness of 5 cm. Endocrine disruptor ethinylestradiol can be removed from the to-be-treated water successively through the column, and through the degradation of soil natural microorganisms and the physical adsorption of the filter materials. Through the system, the removal rate of ethinylestradiol in reclaimed water is 99% or above, and the average removal rate is about 90% for high-concentration distribution water containing 10 <mu>g / L of EE2. The average of operation apparent permeability of the system is 1.26cm / s, the system is high in hydraulic load and low in site condition requirements. Plugging is an important factor affecting the application of artificial soil layer rapid infiltration system engineering. The system can operate for a long time under high hydraulic load, and can effectively remove the target pollutant EE2.