The invention discloses a fully-sealed transmission mechanism of a semi-rotating shuttle sewing machine. The fully-sealed transmission mechanism comprises an upper housing case, a lower housing case, a lower main shaft, a swinging gear shaft, an upper main shaft, a link rod and a sealing box body arranged in the upper housing case, wherein the lower main shaft is arranged in the lower housing case, and is provided with a lower main shaft gear; the swinging gear shaft is arranged on the lower side of the lower main shaft, and is provided with a swinging gear meshed with the lower main shaft gear; and the upper main shaft horizontally passes through the sealing box body in the upper housing case, and is provided with a cam; the cam on the upper main shaft and the pin shaft of the swinging gear are respectively sleeved with the two ends of the link rod; the upper main shaft and the cam are of an integral structure, and the outer diameter of one side of the cam is smaller than the semidiameter of the upper main shaft. The fully-sealed transmission mechanism connects the cam with the upper main shaft into a whole under the condition that the eccentric distance remains unchanged, thereby reducing the volume. Besides, the perfect-sealed transmission mechanism runs in the machine oil in the sealing box body, thereby solving the difficult problems that the prior product has large noise, the machine oil pollutes the sewing, the abrasion is fast, the rotating speed is low, and the maintenance is inconvenience, and greatly improving the service life and the working efficiency.