Abiduoer granular formulation

A technology of arbidol and arbidol hydrochloride, which can be used in antiviral agents, medical preparations with non-active ingredients, organic active ingredients, etc., can solve problems such as poor compliance, reduce costs, and reduce the amount of auxiliary materials. Effect

Active Publication Date: 2006-11-29
SICHUAN BAILI PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, children and elderly patients have poor compliance with tablet medication, and because Arbidol itself is insoluble in water and has a bitter taste, if it is made into granules, it needs to solve the problem of solubility and taste

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0014] 1. Prescription and prescription basis of Arbidol granules

[0015] 1.1 Particle Composition

[0016] Arbidol hydrochloride (press C 22 h 25 BrN 2 o 3 S·HCl) 100.0g main drug

[0017] Lactose 570.0g Excipients

[0018] Mannitol 900.0g Excipient

[0019] Aspartame 30.0g flavoring

[0020] Hypromellose 100.0g Suspending agent

[0021] Povidone 300.0g Adhesive

[0022] 75% ethanol Appropriate amount Solvent

[0023] A total of 1000 bags were made, each weighing 2.0g, containing 0.1g of the main drug.

[0024] 1.2 Screening basis

[0025] (1) Based on the main drug content

[0026] The dose of Arbidol hydrochloride granules is determined according to the specifications of foreign tablets, and the main drug content is 0.1g of Arbidol hydrochloride in each bag.

[0027] (2) Prescription basis

[0028] Arbidol hydrochloride is an off-white crystalline powder, almost insoluble in water. The process adopts wet granulation with 75% ethano...

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PUM

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Abstract

An Abiduoer particle is proportionally prepared from Abiduoer hydrochloride, excipient, suspending aid, adhesive and solvent.

Description

technical field [0001] The invention relates to an Arbidol granule used for preventing and treating influenza and acute viral respiratory tract infection caused by A and B viruses in adults and children. Background technique [0002] Influenza and acute respiratory viral infection (ARVI) are diseases with a high clinical incidence and a wide range of diseases, and children and the elderly are susceptible groups. Arbidol hydrochloride is a new anti-influenza and acute respiratory viral infection drug, and its tablet was listed in the former Russia in 1993. However, children and elderly patients have poor compliance with tablet medication, and because Arbidol itself is insoluble in water and has a bitter taste, it needs to solve the solubility and mouthfeel problems if it is made into granules. Contents of the invention [0003] The technical problem to be solved by the present invention is to provide an Arbidol granule with good taste and good medication compliance. [00...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/404A61K47/34A61P31/16A61P11/00A61K47/18A61K47/20A61K47/26A61K47/32A61K47/38
Inventor 朱义谭光星王云龙
Owner SICHUAN BAILI PHARM CO LTD
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