Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Rotula of acetaminopher suitable for children to take, and prepartion method

A technology of acetaminophen sugar pills and acetaminophen, which is applied in the field of medicine and can solve the problems of large amount of excipients, inaccurate dosage, poor drug compliance, etc.

Inactive Publication Date: 2006-12-06
毛晓敏
View PDF0 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0013] The purpose of the present invention is to overcome the disadvantages of inconvenient swallowing, poor drug compliance, inaccurate dosage, need for water infusion, large amount of auxiliary materials, poor stability and the like existing in the common preparation of acetaminophen in the prior art, and provide a kind of taste sweet, Acetaminophen sugar pills with high bioavailability, good drug compliance, accurate dosage, rapid onset and high bioavailability and preparation method thereof

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0092] 1. Formulation

[0093] Acetaminophen 80g

[0094] 200g powdered sugar

[0095] Mannitol 60g

[0096] Citric acid 3g

[0097] Vanillin 2g

[0098] Chlorophyll 1g

[0099] Magnesium stearate 0.5g

[0100] 2. Preparation method

[0101] Take paracetamol, powdered sugar, compressible starch, mannitol, citric acid, and chlorophyll, mix well, granulate with 5% PVP ethanol solution, dry, add vanillin, magnesium stearate, mix well , compressed into sugar pills, and coated.

[0102] Paracetamol and the above-mentioned auxiliary materials are all passed through a 120-mesh sieve. 50% ethanol can also be used during granulation, and the drying temperature is controlled at 40-60°C. The content uniformity of the prepared sugar pills was determined to be good.

Embodiment 2

[0104] 1. Formulation

[0105] Acetaminophen 160g

[0106] 150g powdered sugar

[0107] Pregelatinized starch 50g

[0108]Aspartame 2g

[0109] Micronized silica gel 1g

[0110] Magnesium Stearate 1g

[0111] Orange flavor 2g

[0112] 2. Preparation method

[0113] Take acetaminophen, sugar powder, pregelatinized starch, and aspartame, mix well, granulate with 4% PVP ethanol solution, dry, add orange essence, micronized silica gel, magnesium stearate, mix well, and press into sugar pill.

[0114] Paracetamol and the above-mentioned auxiliary materials are all passed through a 120-mesh sieve. 80% ethanol can also be used during granulation, and the drying temperature is controlled at 40-60°C. The content uniformity of the prepared sugar pills was determined to be good.

Embodiment 3

[0116] 1. Formulation

[0117] Acetaminophen 80g

[0118] 120g powdered sugar

[0119] Mannitol 75g

[0120] Cyclamate 2g

[0121] Strawberry essence 2g

[0122] Magnesium Stearate 1g

[0123] Monascus pigment 1g

[0124] 2. Preparation method

[0125] Acetaminophen, powdered sugar, mannitol, cyclamate and monascus pigment are mixed evenly, granulated with 4% PVP ethanol solution, dried, strawberry essence and magnesium stearate are added, mixed evenly, and pressed into sugar pills.

[0126] Paracetamol and the above-mentioned auxiliary materials are all passed through a 120-mesh sieve. 80% ethanol can also be used during granulation, and the drying temperature is controlled at 40-60°C. The content uniformity of the prepared sugar pills was determined to be good.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

A sweet pill of acetylaminophenol is disclosed, which is suitable for children. Its preparing process is also disclosed.

Description

technical field [0001] The invention relates to the field of medicine, in particular to an acetaminophen sugar pill suitable for children and a preparation method thereof. Background technique [0002] Acetaminophen, also known as paracetamol, is an aniline antipyretic and analgesic drug that acts on the hypothalamic thermoregulation center, increases the pain threshold, and promotes peripheral blood vessel expansion and blood flow acceleration. The intensity of inhibition of prostaglandin synthesis in the central nervous system is similar to that of aspirin. It has no side effects of the latter, has little irritation to the gastrointestinal tract, has no effect on platelets and blood coagulation mechanisms, and has no damage to the liver under normal doses. It is a relatively safe and effective antipyretic analgesics. Oral absorption is rapid and complete. Clinically, it is mainly used for colds, fever, headache, muscle pain, etc., to eliminate simple pain and discomfort ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K31/167A61K31/4402A61K31/485A61K31/522A61K35/413A61K9/28A61P29/00A61K31/137
Inventor 毛晓敏
Owner 毛晓敏
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com