Rotula of acetaminopher suitable for children to take, and prepartion method

A technology of acetaminophen sugar pills and acetaminophen, which is applied in the field of medicine and can solve the problems of large amount of excipients, inaccurate dosage, poor drug compliance, etc.

Inactive Publication Date: 2006-12-06
毛晓敏
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0013] The purpose of the present invention is to overcome the disadvantages of inconvenient swallowing, poor drug compliance, inaccurate dosage, need for water infusion, large amount of auxiliary materials, poor stability and the like existing in th

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0092] 1. Formulation

[0093] Acetaminophen 80g

[0094] 200g powdered sugar

[0095] Mannitol 60g

[0096] Citric acid 3g

[0097] Vanillin 2g

[0098] Chlorophyll 1g

[0099] Magnesium stearate 0.5g

[0100] 2. Preparation method

[0101] Take paracetamol, powdered sugar, compressible starch, mannitol, citric acid, and chlorophyll, mix well, granulate with 5% PVP ethanol solution, dry, add vanillin, magnesium stearate, mix well , compressed into sugar pills, and coated.

[0102] Paracetamol and the above-mentioned auxiliary materials are all passed through a 120-mesh sieve. 50% ethanol can also be used during granulation, and the drying temperature is controlled at 40-60°C. The content uniformity of the prepared sugar pills was determined to be good.

Embodiment 2

[0104] 1. Formulation

[0105] Acetaminophen 160g

[0106] 150g powdered sugar

[0107] Pregelatinized starch 50g

[0108]Aspartame 2g

[0109] Micronized silica gel 1g

[0110] Magnesium Stearate 1g

[0111] Orange flavor 2g

[0112] 2. Preparation method

[0113] Take acetaminophen, sugar powder, pregelatinized starch, and aspartame, mix well, granulate with 4% PVP ethanol solution, dry, add orange essence, micronized silica gel, magnesium stearate, mix well, and press into sugar pill.

[0114] Paracetamol and the above-mentioned auxiliary materials are all passed through a 120-mesh sieve. 80% ethanol can also be used during granulation, and the drying temperature is controlled at 40-60°C. The content uniformity of the prepared sugar pills was determined to be good.

Embodiment 3

[0116] 1. Formulation

[0117] Acetaminophen 80g

[0118] 120g powdered sugar

[0119] Mannitol 75g

[0120] Cyclamate 2g

[0121] Strawberry essence 2g

[0122] Magnesium Stearate 1g

[0123] Monascus pigment 1g

[0124] 2. Preparation method

[0125] Acetaminophen, powdered sugar, mannitol, cyclamate and monascus pigment are mixed evenly, granulated with 4% PVP ethanol solution, dried, strawberry essence and magnesium stearate are added, mixed evenly, and pressed into sugar pills.

[0126] Paracetamol and the above-mentioned auxiliary materials are all passed through a 120-mesh sieve. 80% ethanol can also be used during granulation, and the drying temperature is controlled at 40-60°C. The content uniformity of the prepared sugar pills was determined to be good.

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PUM

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Abstract

A sweet pill of acetylaminophenol is disclosed, which is suitable for children. Its preparing process is also disclosed.

Description

technical field [0001] The invention relates to the field of medicine, in particular to an acetaminophen sugar pill suitable for children and a preparation method thereof. Background technique [0002] Acetaminophen, also known as paracetamol, is an aniline antipyretic and analgesic drug that acts on the hypothalamic thermoregulation center, increases the pain threshold, and promotes peripheral blood vessel expansion and blood flow acceleration. The intensity of inhibition of prostaglandin synthesis in the central nervous system is similar to that of aspirin. It has no side effects of the latter, has little irritation to the gastrointestinal tract, has no effect on platelets and blood coagulation mechanisms, and has no damage to the liver under normal doses. It is a relatively safe and effective antipyretic analgesics. Oral absorption is rapid and complete. Clinically, it is mainly used for colds, fever, headache, muscle pain, etc., to eliminate simple pain and discomfort ...

Claims

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Application Information

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IPC IPC(8): A61K31/167A61K31/4402A61K31/485A61K31/522A61K35/413A61K9/28A61P29/00A61K31/137
Inventor 毛晓敏
Owner 毛晓敏
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