Application of medication composition of containing extractive of astragalus root in preparing medicine for treating insufficiency of blood supply for brain

A technology of cerebral insufficiency and astragalus extract, which is applied in the field of medicine, can solve the problems of long-term efficacy that needs further research and no focal neurological signs in the brain.

Inactive Publication Date: 2006-12-06
TIANJIN TASLY PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0033] 3. No focal neurological signs of the brain
[0043] 3. No focal neurological signs of the brain;
[0044] 4. CT\MRI without vascular organic brain changes;
[0056] At present, the drugs used clinically to treat CCCI include: THA: cholinesterase inhibitor, GST-21: central N-choline receptor inhibitor, FK506: immunosuppressant, Nimsuperzine: Cox-2 inhibitor, etc. A good short-term clinical effect has been achieved, but the long-term effect needs further study

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0089] 1. Preparation of Astragalus Extract

[0090] Take the Astragalus, add 10 times the amount of purified water, boil for 2 hours, take all the liquid medicine, add 6 times the amount of purified water to the medicine residue, boil for 1.5 hours, take the whole liquid, combine the two extracts, high-speed tube centrifuge ( 2000r / min) to remove impurities by centrifugation, concentrate to 1 / 2 volume (density 1.09-1.11), spray drying (inlet air 175°C, outlet temperature 90°C, wind pressure 0.5Mpa) to get.

[0091] 2. Preparation of Zhimu extract

[0092] Take 10Kg of Zhimu, add 8 times the amount of 80% edible alcohol and reflux for 2 hours; filter, add 80% edible alcohol and 6 times the amount of reflux for 1.5 hours, filter, combine the two filtrates, and concentrate under reduced pressure until no alcohol taste ( Density 1.09-1.11), spray drying (inlet air 175°C, outlet temperature 90°C, wind pressure 0.5Mpa).

[0093] 3. Preparation of capsules

[0094] 82 parts of Astragalu...

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PUM

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Abstract

An application of the medicinal composition composed of astragalus root and anemarrhena rhizome in preparing the medicines for treating chronic cerebral ischemia is disclosed.

Description

Technical field [0001] The invention belongs to the field of medicine, and specifically relates to the application of a pharmaceutical composition containing an astragalus extract in the preparation of a medicine for treating chronic cerebral insufficiency. Background technique [0002] Origin of the concept [0003] Chronic Cerebral Circulation Inefficiency (CCCI) refers to a state where the blood supply to the whole brain is reduced (less than 40-60ml / 100g brain tissue / minute), rather than focal cerebral ischemia. It is a relatively new disease name proposed in the first 10 years abroad. Clinically, there are often elderly or pre-elderly patients who repeatedly complain of conscious symptoms such as heavy head and dizziness. Except for fundus arteriosclerosis, they have neither focal signs of nerve damage nor abnormal brain CT. These patients are often diagnosed as "brain Arteriosclerosis". As we all know, the concept and clinical diagnostic crite...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8964A61P9/10A61P9/02
Inventor 范立君郑永锋
Owner TIANJIN TASLY PHARMA CO LTD
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