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Methods and products which utilize N-acyl-L-aspartic acid

一种烷基、芳基的技术，应用在利用N－酰基－L－天冬氨酸和产品领域

Inactive Publication Date: 2006-12-27
DMI BIOSCIENCES INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Furthermore, the presence of inflammation in many diseases such as cancer predicts a poor prognosis

Method used

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  • Methods and products which utilize N-acyl-L-aspartic acid
  • Methods and products which utilize N-acyl-L-aspartic acid
  • Methods and products which utilize N-acyl-L-aspartic acid

Examples

Experimental program
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Effect test

Embodiment approach

[0028] A. Compound

[0029] The present invention provides methods and products using a compound of formula I or a pharmaceutically acceptable salt thereof:

[0030] R 1 -C(O)-NH-CH 2 (CH 2 -COOR 2 )-COOR 2 (I)

[0031] among them

[0032] R 1 Is H, lower alkyl or lower alkyl substituted by halogen atoms, and

[0033] R 2 , Each R 2 They may be the same or different and are H or alkyl, cycloalkyl, aryl, alkaryl or aralkyl, each of which may be optionally substituted with a polar substituent.

[0034] Highly preferred is N-acetyl-L-aspartic acid (NAA) or a pharmaceutically acceptable salt of NAA.

[0035] "Alkyl" as used herein means a linear or branched saturated hydrocarbon, preferably containing 1-30 carbon atoms, more preferably containing 1-20 carbon atoms (e.g., methyl, ethyl, propyl, isopropyl Wait).

[0036]As used herein, "aryl" means an aryl group containing at least one aromatic ring (e.g., phenyl).

[0037] As used herein, "alkaryl" means an alkyl group having an ary...

Embodiment 1

[0188] Although N-acetyl-aspartic acid (NAA) has been shown to play an important role in myelin synthesis and osmotic pressure regulation, the biological principle of high levels of NAA in the brain is still unknown. In this example, a human astrocyte cell line (STTG) was treated with NAA and stimulated with Ionomycin or IL-1β. By measuring inflammatory mediators such as prostaglandin E 2 (PGE 2 ), cyclooxygenase-2 (COX-2) protein and activated NFκB to study the secondary inflammatory response. When NAA concentration is 10 and 20mM, PGE in STTG cells stimulated by Ionomycin 2The levels have dropped by 76% and >95%, respectively. Glutamate receptor antagonists (L-AP-4 and L-glutamate diethyl ester) also caused a decrease in PGE2 levels in STTG cell lines. NAA also reduced the amount of COX-2 protein and activated NFκB in STTG cells stimulated by IL-1β, but had little effect on unstimulated cells. NAA has no effect on overall COX-2 activity or COX-2 mRNA. These results demonstrate t...

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Abstract

The invention provides therapeutic methods and products for the treatment of inflammation, inflammatory diseases and conditions, and proliferative diseases and conditions. The invention also provides methods and products for inhibiting inflammation in excised cells, tissues and organs. The invention further provides oral care methods and products for the treatment of the tissues of an animal's mouth. Finally, the invention provides personal care methods and products for the treatment of the skin of an animal. All of these methods and products utilize N-acyl-L-aspartic acid or an ester or pharmaceutically-acceptable salt thereof.

Description

Invention field [0001] The present invention relates to methods and products using N-acyl-L-aspartic acid or its esters or pharmaceutically acceptable salts. In a preferred embodiment, the present invention relates to treatment methods and products for the treatment of inflammation, inflammatory diseases and disorders, and proliferative diseases and disorders. In another embodiment, the invention relates to methods and products for treating resected cells, tissues and organs. In another embodiment, the present invention also relates to oral care methods and products for treating the oral cavity of animals. In a fourth embodiment, the present invention relates to personal care methods and products particularly for the treatment of animal skin. Background of the invention [0002] Inflammation is a cascading event. The body responds to various injuries, infections and stress through inflammation. The inflammatory response is the key to stress response, fighting infection and healin...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/198A61DA61D7/00A61K31/195A61K31/225
CPCA61D7/00A61P1/02A61P1/04A61P9/00A61P9/10A61P11/00A61P11/06A61P17/00A61P17/02A61P17/06A61P17/10A61P29/00A61P31/04A61P35/00A61K31/185A61K31/195A61K31/198
Inventor 戴维·巴尔-奥尔伦纳德·T·雷尔
Owner DMI BIOSCIENCES INC
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