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Red sage root dispersible tablet for treating cornary heart diseae and its preparing method

A technology for Guanxin Danshen and dispersible tablets, applied in the field of Guanxin Danshen dispersible tablets and their preparation, can solve the problems of poor oral absorption of tanshinones and the like, and achieve the effect of improving the dissolution rate

Inactive Publication Date: 2007-01-10
上海海刚仪器科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Pharmacokinetic experiments also prove that tanshinones are poorly absorbed orally

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0072] Salvia 200g

[0073] Panax notoginseng (fine powder) 200g

[0074] Dalbergia oil-β-CD inclusion compound 16g

[0075] Microcrystalline cellulose 100g

[0076] Low-substituted hydroxypropyl methylcellulose 40g

[0077] 5% polyvinylpyrrolidone appropriate amount

[0078] Magnesium stearate 4g

[0079] 1000 pieces in total

[0080] Preparation method: pulverize 200g of Salvia miltiorrhiza to be coarse powder, wet it with 90% ethanol twice to expand it, put it into the percolator, add 6 times the amount of 90% ethanol and soak for 24 hours, then percolate and collect Recycle the ethanol until it has no alcohol taste, and concentrate at 50℃ to a relative density of 1.20; add 4 times the amount of water to the dregs and cook twice for 1 hour each time, combine the decoction, filter, and concentrate the filtrate to a relative density of 1.25(50℃), add 200g of Panax notoginseng powder, 16g of the above thick paste, cyclodextrin inclusion compound of dalbergia oil, 40g of low-substi...

Embodiment 2

[0082] Salvia 200g

[0083] Panax notoginseng (fine powder) 200g

[0084] Dalbergia oil-β-CD inclusion compound 16g

[0085] Microcrystalline cellulose 100g

[0086] Low-substituted hydroxypropyl methylcellulose 60g

[0087] 5% polyvinylpyrrolidone appropriate amount

[0088] Magnesium stearate 4g

[0089] 1000 pieces in total

[0090] Preparation method: crush 200g of Danshen powder into coarse powder, wet it with 90% ethanol twice to expand it, put it into the percolator, add 8 times 90% ethanol and soak for 24 hours, then percolate. Collect the glutinous liquid, recover the ethanol until it has no alcohol taste, and concentrate at 50℃ to a relative density of 1.20; add 6 times the amount of water to decocting the medicine residue twice for 1 hour each time, combine the decoction, filter, and concentrate the filtrate to the relative density It is 1.25 (50℃), add 200g of panax notoginseng powder, 16g of the above thick paste, cyclodextrin inclusion compound of dalbergia oil, low-...

Embodiment 3

[0092] Salvia 200g

[0093] Panax notoginseng (fine powder) 200g

[0094] Dalbergia oil-β-CD inclusion compound 16g

[0095] Microcrystalline cellulose 100g

[0096] Sodium Carboxymethyl Starch 40g

[0097] 5% polyvinylpyrrolidone appropriate amount

[0098] Magnesium stearate 4g

[0099] 1000 pieces in total

[0100] Preparation method: pulverize 200g of Salvia miltiorrhiza to be coarse powder, wet it with 90% ethanol twice to make it expand, put it into the percolator, add 10 times of 90% ethanol and soak for 24 hours, then percolate and collect Recycle the ethanol until there is no alcohol taste, and concentrate at 50℃ to a relative density of 1.20; add 8 times the amount of water to the dregs and cook twice for 1 hour each time, combine the decoction, filter, and concentrate the filtrate to a relative density of 1.25 (50°C), add 200g of Panax notoginseng powder, 16g of the above thick paste, cyclodextrin inclusion compound of dalbergia oil, 40g of sodium carboxymethyl starch a...

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PUM

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Abstract

The present invention discloses a composition of Guanxin Danshen dispersion tablet and its preparation method. Said dispersion tablet is made up by using salvia root extract, notoginseng powder, dalbergia oil, cyclodextrin inclusion compound, disintegrating agent, bulking agent and adhesive through a certain preparation process.

Description

Technical field [0001] The invention relates to the technical field of traditional Chinese medicine preparations, in particular to a Guanxin Danshen dispersible tablet and a preparation method thereof. Background technique [0002] Guanxin Danshen Tablets (Chinese Pharmacopoeia 2005 Edition One, 550), Guanxin Danshen Capsules (Chinese Pharmacopoeia 2005 Edition One, 550) and many more are made with Danshen, Panax Notoginseng and Dalbergia oil as raw materials. An oral preparation. There are two types of effective parts in Salvia miltiorrhiza with the activity of promoting blood circulation and removing blood stasis: fat-soluble tanshinones and water-soluble salvianolic acids. Numerous studies have shown that tanshinone has a wide range of effects on the cardiovascular system, mainly manifested as endothelial cell protection, anti-myocardial ischemia, improving blood metabolism, and protecting the myocardium. Mechanism studies have proved that tanshinone has a protective effect on...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/537A61K9/28A61P9/10
Inventor 陈麟林李云森吴家虎
Owner 上海海刚仪器科技有限公司
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