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Nizatidine dispersion tablets

A technology of dispersible tablets and weight percent, applied in the field of nizatidine dispersible tablets and immediate-release preparations, can solve the problems of slow dissolution rate, slow disintegration, inconvenient use, carrying and transportation, storage, etc., to improve the speed of absorption , the effect of accelerating release and reducing disintegration time

Inactive Publication Date: 2007-01-31
湖南威特制药股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Existing nizatidine preparations have dosage forms such as ordinary tablets, capsules, injections, etc., but are subject to certain restrictions in clinical use and promotion.
Due to the poor water solubility of nizatidine, ordinary tablets and capsules have the problems of slow disintegration and slow dissolution rate, which affects the absorption effect of patients; although injections have high bioavailability, they are difficult to use, carry, transport and store. inconvenient

Method used

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  • Nizatidine dispersion tablets

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Nizatidine 150g

[0018] Microcrystalline Cellulose 90

[0019] Low-substituted hydroxypropyl cellulose 10

[0020] Sodium Carboxymethyl Cellulose 8

[0021] Magnesium Stearate 1.3

[0022] Nizatidine, microcrystalline cellulose, and low-substituted hydroxypropyl cellulose were respectively passed through a 100-mesh sieve, mixed evenly, and an appropriate amount of 1% povidone K30 was added to make a soft material, and granulated with a 24-mesh sieve. Dry the wet granules at about 60°C, then granulate with a 24-mesh sieve, add sodium carboxymethyl cellulose and magnesium stearate, mix well, take samples for inspection, and control the pressure at 6-8kg for tableting.

Embodiment 2

[0024] Nizatidine 150g

[0025] Microcrystalline Cellulose 70

[0026] pregelatinized starch 20

[0027] Low-substituted hydroxypropyl cellulose 10

[0028] Sodium Carboxymethyl Cellulose 8

[0029] Magnesium Stearate 1.3

[0030] Pass Nizatidine, microcrystalline cellulose, pregelatinized starch, and low-substituted hydroxypropyl cellulose through a 100-mesh sieve, mix well, add 1% povidone K30 to make a soft material, and use a 24-mesh sieve Granulation. The wet granules are dried at about 60°C, then sized with a 24-mesh sieve, added with sodium carboxymethyl cellulose and magnesium stearate, mixed well and then sampled for inspection. The pressure is controlled at 6-8kg for tableting.

[0031] Example 2:

[0032] Nizatidine 150g

[0033] Microcrystalline Cellulose 80

[0034] pregelatinized starch 20

[0035] Low-substituted hydroxypropyl cellulose 10

[0036] Sodium Carboxymethyl Cellulose 8

[0037] Magnesium Stearate 1.3

[0038] Pass Nizatidine, microcrystal...

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Abstract

A dispersing tablet of nizatitine is prepared proportionally from nizatidine, diluent, disintegrant, lubricant and adhesive.

Description

technical field [0001] The invention relates to a nizatidine dispersible tablet for treating duodenal ulcer and benign gastric ulcer, which belongs to the quick release preparation technology. Background technique [0002] Pharmacological studies have shown that nizatidine is a H 2 Receptor blockers that reversibly compete with histamine for H 2 Receptor, inhibits the increase of gastric acid secretion caused by various reasons. Existing nizatidine preparations have dosage forms such as common tablet, capsule, injection, but all be subjected to certain restriction on clinical use and popularization. Due to the poor water solubility of nizatidine, ordinary tablets and capsules have the problems of slow disintegration and slow dissolution rate, which affects the absorption effect of patients; although injections have high bioavailability, they are difficult to use, carry, transport and store. inconvenient. Dispersible tablet is an immediate-release dosage form developed in...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/426A61K9/20A61P1/04
Inventor 肖仕杰李莉
Owner 湖南威特制药股份有限公司