A feeding chamber, an apparatus and a method for production of doses of dry powder, a method for controlling particle segregation in dry powder during filling

A technology of powder particles and chambers, applied in the field of supply chambers, equipment for manufacturing dry powder medicaments and controlling the separation of particles in dry powders during filling, which can solve the difficulties of medicament metering, powder bulk density changes, filling medicaments container and other issues, to achieve the effect of controllable particle separation and low particle separation

Inactive Publication Date: 2007-02-21
MEDERIO AG
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

This makes dosing the correct dose more difficult, as the bulk density of the powder varies significantly from dose to dose, even when the bulk density is constant when measur

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  • A feeding chamber, an apparatus and a method for production of doses of dry powder, a method for controlling particle segregation in dry powder during filling
  • A feeding chamber, an apparatus and a method for production of doses of dry powder, a method for controlling particle segregation in dry powder during filling
  • A feeding chamber, an apparatus and a method for production of doses of dry powder, a method for controlling particle segregation in dry powder during filling

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Embodiment Construction

[0032] The present invention discloses apparatus and apparatus for accurately metering and volumetric filling of dry powder pharmaceutical medicaments into preformed containers, wherein the medicaments and containers are suitable for administration by inhalation using a dry powder inhaler (DPI). The method of the present invention is expressed in figure 1 in the flow chart.

[0033] Prior art methods and apparatus use a primarily cylindrical filling tool having a plurality of generally conical metering cavities, receptacles that are filled from a bulk powder source that holds the bulk powder. The cylindrical filling tool is then rotated to an emptying position where the filled receptacle is emptied into the appropriate package. However, since the filling process affects the amount of powder involved in the filling process, a considerable fine particle portion of the powder is filled into the receptacle, and the amount of powder filled into the receptacle varies with time. En...

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Abstract

The invention discloses a method and an apparatus for exact metering and volumetric filling of dry powder medicament doses into preformed containers, which are adapted for administration by means of a dry powder inhaler (DPI). The filling apparatus of the invention includes at least a bulk powder source (401), a feeding chamber (134) and a receptacle (110) providing the volume for a specified load mass (202) of dry powder. The bulk powder source releases a portion of powder discontinuously to the feeding chamber, but is disconnected from the feeding chamber and receptacle during the filling operation. The filling apparatus further presents a plane surface (103) in contact with the movable feeding chamber and provides a hard-wearing, low friction coating for reducing dynamic friction and powder retention.

Description

technical field [0001] The present invention relates to a method and apparatus for filling a series of receptacles with a metered dose of fine dry powder, which is inhaled by a dry powder inhaler (DPI). Background technique [0002] Medication administration is accomplished in many different ways in today's medical industry. In healthcare, there is growing interest in medical products that deliver drug products by inhaling dry powders directly into the airways and lungs of patients. Dry powder inhalers (DPIs) are of general interest because of their ability to efficiently, quickly and conveniently deliver many different substances formulated as dry powder doses for the treatment of many different ailments. Because of the faster onset of action and the fact that inhaled doses are generally more effective than oral capsules or tablets, the amount required for an inhaled dose is only a fraction of the amount of powdered drug required for an oral capsule or tablet. Accordingly...

Claims

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Application Information

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IPC IPC(8): B65B1/36A61M15/00A62C5/02B05B7/04B05D1/00B65BF23D11/36F23D11/40G01F11/24
CPCA61M2015/005G01F11/24A61M15/0045A61M2202/064A61M15/005B05B7/04B05D1/00B65B1/36F23D11/36
Inventor L·卡克斯C·弗里贝里
Owner MEDERIO AG
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