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Method for preparing and rographalide

A technology of andrographolide and andrographolide, applied in the field of preparation of andrographolide, which can solve the problems of low yield, difficult extraction, and many organic residues

Inactive Publication Date: 2007-03-28
TIANJIN TASLY PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Industrial extraction is difficult, the yield is low, and more organic residues are introduced

Method used

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  • Method for preparing and rographalide

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] Extract with ethanol:

[0046] Take 400g of Andrographis paniculata, crush it into coarse powder or slices (0.3mm / section), add 8 times the amount of 75% ethanol to reflux and extract twice, each time for 1 hour; filter, combine the filtrates, let cool, and set aside.

[0047] Isolation and Purification:

[0048] AB-8 type macroporous resin (resin volume 400ml) on the ethanol extract, flow rate 2-2.5BV / h. Collect the filtrate, concentrate under reduced pressure below 70°C until the alcohol concentration is 20-28%, filter, wash the precipitate with ethanol of the same concentration, mix with the filtrate to a volume of 400ml, and set aside. Get the filtrate, put on AB-8 type macroporous resin (resin volume 400ml) flow rate 1-1.5BV / h, wash with 30% ethanol of 4 times of column volume, then use 6 times of amount of 35-40% ethanol, elute, collect and wash Remove liquid, add 8g of 200-300 mesh silica gel, concentrate to dryness under reduced pressure below 70°C, wash with ...

Embodiment 2

[0059] Extract with ethanol:

[0060] Take 400g of Andrographis paniculata, crush it into coarse powder or slices (0.3mm / segment), add 8 times the amount of 85% ethanol to reflux and extract twice, each time for 1 hour; filter, combine the filtrates, let cool, and set aside.

[0061] Isolation and Purification:

[0062] AB-8 type macroporous resin (resin volume 400ml) on the ethanol extract, flow rate 2-2.5BV / h. Collect the filtrate, concentrate under reduced pressure below 70°C until the alcohol concentration is 20-28%, filter, wash the precipitate with ethanol of the same concentration, mix with the filtrate to a volume of 400ml, and set aside. Get the filtrate, put it on the AB-8 type macroporous resin (resin volume 400ml) flow rate 1-1.5BV / h, wash with 4 times of column volume 30% ethanol, then use 6 times of 35-40% ethanol to elute, collect and wash Remove liquid, add 8g of 200-300 mesh silica gel, concentrate to dryness under reduced pressure below 70°C, wash with acet...

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Abstract

The invention relates to an andrographolide preparing method, especially relating to a method for separating and purifying andrographolide with macroporous resin.

Description

Technical field: [0001] The invention relates to a preparation method of andrographolide, in particular to a method for separating and purifying andrographolide with a macroporous resin. Background technique: [0002] Andrographolide, synonym: Andrographolide B [0003] The structural formula is as follows: [0004] [0005] Molecular formula: C 20 h 30 o 5 [0006] Molecular weight: 350.44 [0007] Andrographolide is a diterpene lactone compound extracted from the plant of Acanthaceae, andrographis paniculata. It is one of the main active ingredients of the traditional Chinese medicine Andrographis paniculata. It has the functions of clearing away heat and detoxification, cooling blood and reducing swelling. It has a special effect on bacterial and viral upper respiratory tract infections and dysentery, and is known as a natural antibiotic drug. Modern pharmacological studies have shown that andrographolide and its derivatives (such as dehydroandrographolide succi...

Claims

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Application Information

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IPC IPC(8): C07D307/60
Inventor 张文生
Owner TIANJIN TASLY PHARMA CO LTD
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