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Leave of glutinous rehmannia extractive, its prepn. method and use, medicines prepd. with said extractives

An extract and the technology of rehmannia glutinosa, which are applied in the field of rehmannia glutinosa extract and its preparation, achieve remarkable curative effect, alleviate the contradiction between supply and demand, and have good safety effects

Active Publication Date: 2007-04-18
SICHUAN MEDCO PHARML
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no use of rehmannia root to extract active ingredients rehmannia glucosides for medicinal or other purposes

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] 1. After pulverizing the dried rehmannia leaves or rehmannia stems and leaves, add solvent 400L (for the first time) and 350L (for the second time) with 50kg of rehmannia rehmannia leaves (or rehmannia stems and leaves), and the solvent adopts ethanol with a concentration of 80% (wherein Containing 0.5% glacial acetic acid by volume), reflux extraction twice at 80° C. for 1 hour each time, and the extract was collected.

[0039] ②. Filtrate the extract, and concentrate the filtrate at 60-70°C to a concentrated solution a with a relative density of 1.02-1.04 (50-60°C).

[0040] ③. Let the concentrated liquid a stand for clarification, take the supernatant and pass it through the D101 macroporous adsorption resin column, elute the resin column with water 2 times the volume of the resin column, discard the water, and then use 1.5 times the volume of the resin column ethanol solvent (concentration is 50% ethanol: concentration is glacial acetic acid=99.5:0.5 of 5%) to elute...

Embodiment 2

[0045] ①. After pulverizing the dried rehmannia leaves or rehmannia stems and leaves, add 400 L and 350 L of solvent respectively with 50 kg of rehmannia rehmannia leaves (or rehmannia stems and leaves), and use methanol with a concentration of 80% (which contains 0.5% glacial acetic acid by volume), 80 ℃ reflux extraction twice, each time for 1 hour, and the extract was collected.

[0046] ②. Filtrate the extract, and concentrate the filtrate at 60-70°C to a concentrated solution a with a relative density of 1.02-1.04 (50-60°C).

[0047] ③. Let the concentrated solution a stand still for clarification, take the supernatant and pass it through the NKA-II macroporous adsorption resin column, and elute the resin column with water 3 times the volume of the resin column. Then use the ethanol solvent (80% ethanol: 5% glacial acetic acid = 99.5: 0.5) of 3 times the volume of the resin column to elute the resin column, collect the ethanol eluate, and reclaim the ethanol at 60-70°C. ...

Embodiment 3

[0052] ①. After pulverizing the dried rehmannia leaves or rehmannia stems and leaves, add 400 L and 350 L of water (containing 0.5% glacial acetic acid by volume) to 50 kg of rehmannia rehmannia leaves (or rehmannia stems and leaves) respectively, and extract twice under reflux at 75-85 ° C. Each time for 1 hour, the extract was collected.

[0053] ②. Filtrate the extract, and concentrate the filtrate at 60-70°C to a concentrated solution a with a relative density of 1.02-1.04 (50-60°C).

[0054] ③. Let the concentrated solution a stand still for clarification, take the supernatant and pass it through the X-5 macroporous adsorption resin column, and use water twice the volume of the resin column to elute the resin column. Then use the ethanol solvent of 1.5 times of the volume of the resin column (concentration is 80% ethanol: concentration is 5% glacial acetic acid=99.5:0.5) to elute the resin column, collect the ethanol eluent, reclaim ethanol at 60~70°C and Concentrate b c...

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PUM

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Abstract

An extract of rehmannia leaf used for preparing the medicines and health-care food to prevent and treat the renal function diseases, such as albuminuria, hematuria, chronic glomerulonephritis is disclosed. Its preparing process is also disclosed.

Description

[technical field] [0001] The present invention relates to the extraction of plant active ingredients, in particular to a rehmannia root extract, its preparation method and use, and medicine prepared from the extract. [Background technique] [0002] Rehamnnia glutinosa Libosch is a well-known Chinese herbal medicine. It is often used in combination with other Chinese herbal medicines to treat renal diseases. The role of the "jun" medicine. According to tradition, rehmannia root is used as medicine, and its leaves are discarded. Modern pharmacological research shows that the main ingredient contained in the leaves / stems and leaves of Rehmannia glutinosa is total glycosides of rehmannia glutinosa, while the roots of rehmannia glutinosa do not contain total glycosides of rehmannia glutinosa, which can nourish yin and tonify kidney, cool blood and activate blood, absorb essence and stop bleeding. It can be used for proteinuria, hematuria, and chronic glomerulonephritis. It belo...

Claims

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Application Information

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IPC IPC(8): A61K36/804A61P13/12A61K127/00
Inventor 边宝林杨建何纬张祝君卿光明李彦胡德模
Owner SICHUAN MEDCO PHARML
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