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Device and method for sorting biological particles

A technology of biological particles and biological information, applied in measurement devices, individual particle analysis, particle and sedimentation analysis, etc., can solve the problems of reduced classification accuracy and complicated operations.

Inactive Publication Date: 2007-04-18
BAY BIOSCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the optimal charge position changes with the viscosity and temperature of the liquid (suspension and protective liquid) and the state of the nozzle, and thus there is a problem that the classification accuracy will decrease
In addition, in order to measure the distance from the detection position to the charge position, a camera is provided, and the distance from the detection position to the charge position can be detected by moving the camera up and down, but such a method requires a mechanism for raising and lowering the camera, so , this method will make the job extremely complicated

Method used

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  • Device and method for sorting biological particles
  • Device and method for sorting biological particles
  • Device and method for sorting biological particles

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Embodiment Construction

[0066] Next, referring to the drawings, an embodiment of the device for obtaining biological particle information, that is, a flow rate inspection meter according to the present invention will be described.

[0067] (1) Optical elements:

[0068] Figure 1 shows the optical elements of a flow inspection meter. As shown in this figure, the flow rate inspection meter 1 has a flow path block (flow path forming part) 2 (refer to FIG. 2 ) in which biological particles (cells or Chromosome) liquid (usually composed of a suspension containing cells and a protective solution) flows through a microscopic channel. The illuminating unit 5 that irradiates light to the guard flow (flow) 4 flowing through the flow channel 3 formed in the flow channel block 2 includes a plurality of excitation light sources. These multiple light sources preferably utilize laser generators that produce laser light of different wavelengths. For example, in this embodiment, three excitation light sources are ...

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Abstract

A device for illuminating a flow of a liquid containing biological particles with light, detecting light from the biological particles, collecting bioinformation on the biological particles, and sorting the biological particles according to the collected bioinformation. The device comprises a light detecting section for detecting light from biological particles, and an imaging section for imaging a flow and a droplet separated from the flow, means for calculating the distance from the detecting position at which a light detector detects light from the biological particles to the flow lower end position and the intervals between particles contained in the flow on the b sis of the flow image captured by the imaging section and calculating the time for the particles to move from the detection position to the lower end position by using the distance and intervals, and means for giving charge of a polarity depending on the properties of the biological particles to the flow after a calculated time from the detection of light from the biological particles by the light detection. Thus, the structure of the biological particle sorting device is simplified, and the accuracy of sorting is improved.

Description

technical field [0001] The present invention relates to a device and method for obtaining biological information of biological particles (eg cells, chromosomes) and classifying the particles based on the obtained biological information. In particular, the present invention relates to a flow rate measuring device and a cell sorter which allow cells or chromosomes dyed with fluorescent pigments to flow in a laminar flow state, and detect information light (stray light) obtained by irradiating light such as laser light to the flow. , fluorescence), and convert the optical information contained in the detected information light into electrical signals to obtain biological information of cells or chromosomes, and extract specific cells or chromosome groups based on the biological information as needed. Background technique [0002] With the development of biotechnology (biotechnology), flow cell analysis devices (flow test meters) for automatic analysis and classification of cell...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N15/14G01N21/47G01N21/64G01N33/483
CPCG01N15/1459G01N2015/149G01N15/1463G01N15/1433G01N15/149
Inventor 神田昌彦
Owner BAY BIOSCI
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