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Medicament for preventing and treating renal calculus through regulating concentration of citric acid in urine

A technology for citric acid and kidney stones, which is used in drug combinations, pharmaceutical formulations, urinary system diseases, etc.

Inactive Publication Date: 2007-05-23
LANZHOU UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, its unbearable side effects, such as damage to the urinary system mucosa, and damage to the body such as local catheterization required for perfusion, etc., make it difficult for these therapies to be widely used clinically.

Method used

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  • Medicament for preventing and treating renal calculus through regulating concentration of citric acid in urine
  • Medicament for preventing and treating renal calculus through regulating concentration of citric acid in urine
  • Medicament for preventing and treating renal calculus through regulating concentration of citric acid in urine

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Embodiment Construction

[0019] The present invention provides relevant experiment and result below:

[0020] Animal experiments The experimental animals used were Waster rats.

[0021] Take 120 Waster rats and randomly divide them into 4 groups according to body weight:

[0022] (1) Control group. Normal feed, free drinking tap water.

[0023] (2) 5% ammonium oxalate group. Feeding feed containing 5% ammonium oxalate, free drinking tap water (the same below) + tap water gavage, 2 times / day.

[0024] (3) Lithium carbonate group. Normal feed, free drinking tap water + 18.2mg / ml lithium carbonate gavage, 2 times / day.

[0025] (4) 5% ammonium oxalate + lithium carbonate group. After feeding with 5% ammonium oxalate feed for 7 days, 18.2 mg / ml lithium carbonate was added to the stomach, 2 times / day.

[0026] In the experiment, (3) group, i.e. lithium carbonate group, was given lithium carbonate 18.2mg / ml.1ml gavage from the beginning, twice a day; After feeding with 5% ammonium oxalate feed for 7 ...

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Abstract

The invention discloses the use of lithium carbonates in preparing medicament for adjusting and controlling concentration of citric acid and prevention and treatment of renal calculus.

Description

technical field [0001] The invention relates to the use of a salt, specifically refers to the use of lithium carbonate to prepare a medicine for regulating and controlling the concentration of urinary citric acid and preventing and treating kidney stones. Background technique [0002] According to reports, there is no significant difference in the absorption of citric acid from the gastrointestinal tract of hypocitrauria patients and normal people. Hypocitraturia is not the result of gastrointestinal malabsorption but is the result of excessive reabsorptive transport by the kidneys. Citric acid is freely filtered from the glomerulus, and the concentration of citrate in the excreted urine depends on the plasma citrate concentration and its reabsorption by the renal proximal tubules. Its excessive reabsorption will result in decreased excretion of citric acid from urine. Through the in vitro study of renal proximal tubule tissue, it was confirmed that the first step of kidne...

Claims

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Application Information

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IPC IPC(8): A61K33/00A61P13/04A61P13/12
Inventor 王志平张向波罗纳德·罗德里格斯
Owner LANZHOU UNIVERSITY