Medicinal composition containing mangiferin and its preparing method
A technology of mangiferin and composition, which is applied in the field of medicinal composition containing mangiferin and its preparation, and can solve the problems of increasing bioavailability, poor solubility, increasing water solubility of mangiferin, etc.
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preparation example 1
[0015] The mango leaves are extracted by percolation with 95% ethanol, the ethanol is recovered under reduced pressure, the thick paste is extracted with petroleum ether and ethyl acetate in sequence, and the solvent is recovered to obtain petroleum ether extraction part, ethyl acetate extraction part and water layer precipitate. The precipitate in the water layer was extracted and cooled with 55% ethanol to obtain yellow needle-like crystals, and mangiferin was obtained through repeated purification. The content of mangiferin determined by HPLC was 90%.
preparation example 2
[0017] Anemarrhena decoction pieces were decocted twice, 1 hour each time, the decoction was concentrated, precipitated with 80% ethanol, the supernatant was taken, the ethanol was recovered under reduced pressure, adsorbed on the macroporous adsorption resin, washed with water until clear, and eluted with 30% ethanol , collect the eluate, recover ethanol under reduced pressure, and dry under reduced pressure to obtain that. The content of mangiferin determined by HPLC was 88%.
Embodiment 1
[0019] Take 100 mg of mangiferin, heat it with about 15 mL of 60% ethanol to dissolve it; weigh 3.0 g of hydroxypropyl-β-cyclodextrin, add 5 mL of water and stir to dissolve at room temperature. Add the mangiferin solution dropwise. After adding the solution, continue to stir until the solution is viscous, and dry under reduced pressure to obtain.
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