Medicinal composition containing mangiferin and its preparing method

A technology of mangiferin and composition, which is applied in the field of medicinal composition containing mangiferin and its preparation, and can solve the problems of increasing bioavailability, poor solubility, increasing water solubility of mangiferin, etc.

Inactive Publication Date: 2007-06-13
海南盛科天然药物研究院有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The purpose of the present invention is to provide a medicinal composition containing mangiferin and its preparation method, without changing the struc

Method used

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  • Medicinal composition containing mangiferin and its preparing method

Examples

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preparation example 1

[0015] The mango leaves are extracted by percolation with 95% ethanol, the ethanol is recovered under reduced pressure, the thick paste is extracted with petroleum ether and ethyl acetate in sequence, and the solvent is recovered to obtain petroleum ether extraction part, ethyl acetate extraction part and water layer precipitate. The precipitate in the water layer was extracted and cooled with 55% ethanol to obtain yellow needle-like crystals, and mangiferin was obtained through repeated purification. The content of mangiferin determined by HPLC was 90%.

preparation example 2

[0017] Anemarrhena decoction pieces were decocted twice, 1 hour each time, the decoction was concentrated, precipitated with 80% ethanol, the supernatant was taken, the ethanol was recovered under reduced pressure, adsorbed on the macroporous adsorption resin, washed with water until clear, and eluted with 30% ethanol , collect the eluate, recover ethanol under reduced pressure, and dry under reduced pressure to obtain that. The content of mangiferin determined by HPLC was 88%.

Embodiment 1

[0019] Take 100 mg of mangiferin, heat it with about 15 mL of 60% ethanol to dissolve it; weigh 3.0 g of hydroxypropyl-β-cyclodextrin, add 5 mL of water and stir to dissolve at room temperature. Add the mangiferin solution dropwise. After adding the solution, continue to stir until the solution is viscous, and dry under reduced pressure to obtain.

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Abstract

The present invention relates to a medicine composition containing mangiferin and its preparation method. It is characterized by that the mangiferin is contained in the cyclodextrin derivative, and the mixing ratio of both them is as follows: mangiferin 1g and cyclodextrin derivative 3g-30g. It can effectively raise solubility and bioavailability of mangiferin.

Description

Technical field: [0001] The invention relates to a medicinal composition containing mangiferin and a preparation method thereof. Background technique: [0002] Mangiferin, also known as mangiferin and Zhimuning, is a natural polyphenol compound extracted from plants such as mango leaves of Anacardiaceae or Anemarrhena of Liliaceae plants. Molecular formula: C 19 h 18 o 11 , molecular weight: 422. Its chemical structure is as follows: [0003] [0004] Pharmacological studies of mangiferin have shown that it has a variety of biological activities, such as anti-oxidation, anti-tumor, anti-bacterial, anti-viral, hypoglycemic, anti-inflammatory, choleretic, immune regulation and so on. However, because this product is almost insoluble in water, its solubility is poor, and its bioavailability is low, which limits its research and development as a new drug to a certain extent. [0005] To this end, we have invented a medicinal composition containing mangiferin through a lo...

Claims

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Application Information

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IPC IPC(8): A61K31/7048A61K47/40A61P39/06A61P35/00A61P31/04A61P31/12A61P37/02A61P29/00A61P3/10A61P1/16
Inventor 滕厚雷于翠翠邵萌翟大伟李子香刘军锋
Owner 海南盛科天然药物研究院有限公司
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