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Chinese-medicinal composition, preparation and use for treating cardiovascular diseases

A composition and a cardiovascular technology, which are applied in the application field of preparing drugs with anti-cardiomyocyte ischemia effect, can solve the problems of difficult quality control, complex chemical composition, unclear drug effect material basis, etc., and achieve simple and clear chemical composition. , the effect of easy quality control

Inactive Publication Date: 2010-12-15
TIANJIN TASLY PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the chemical composition of traditional Chinese medicine is complex, the material basis of medicinal effect is not clear, and it is difficult to control the quality

Method used

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  • Chinese-medicinal composition, preparation and use for treating cardiovascular diseases
  • Chinese-medicinal composition, preparation and use for treating cardiovascular diseases
  • Chinese-medicinal composition, preparation and use for treating cardiovascular diseases

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] The preparation of embodiment one Chinese medicine composition of the present invention

[0043] Take 250 g of Danshen medicinal material, grind it, add ethyl acetate and ethanol (1:1), heat to reflux for 1 hour, extract twice, and combine the filtrates to obtain the extract. The extract is concentrated into extractum 17.2g, the extract and silica gel are mixed as a sample, and separated with a normal phase silica gel column, at first using sherwood oil and ethyl acetate (50: 1) as mobile phase to obtain eluent I, and then The mobile phase was replaced with chloroform and methanol (10:1) to obtain the eluent II, which was concentrated and dried to obtain 2.5 g of the sample. The separation of the resulting sample was continued by preparative liquid chromatography. Separation conditions for preparative chromatography: the chromatographic column is a Hanbang semi-preparative column (Lichrospher C18; 10.0mm×250mm, 5 μm), the mobile phase is water (A) and acetonitrile (B),...

Embodiment 2

[0045] The preparation of embodiment two Chinese medicine compositions of the present invention

[0046] Extract by the method of embodiment one and obtain Danshen extract and paeonol extract, 5.2 * 10 -6 gram salvia extract with 4.8 x 10 -6 The Cortex katan extract was mixed to obtain mixture A.

Embodiment 3

[0047] The preparation of embodiment three Chinese medicine compositions of the present invention

[0048] Extract by the method of embodiment one and obtain Danshen extract and paeonol extract, 4.2 * 10 -6 gram salvia extract with 5.8 x 10 -6 The kotan bark extract was mixed to obtain mixture B.

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Abstract

A Chinese medicine for preventing and treating myocardial ischemia is prepared from the extract of red sage root (52-60 Wt%), the extract of tree peony bark (40-48 Wt%) and medicinal auxiliaries.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition for treating cardiovascular diseases, in particular to effective components dihydrotanshinone I extracted from Salvia miltiorrhiza and effective components paeonidanin (Paeonidanin) and paeonidanin b extracted from paeonol The combination of (Mudanpioside b), the preparation containing the composition, and its application in the preparation of drugs with anti-cardiomyocyte ischemia effect. Background technique [0002] Coronary heart disease and angina pectoris are the "first killers" that endanger human health. In recent years, with the aging of my country's population and changes in people's work, life, diet structure and environment, the incidence of coronary heart disease and other cardiovascular and cerebrovascular diseases has also increased year by year. increase, seriously threatening the physical and mental health of the people. The percentage of deaths due to cardiovascular a...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/71A61P9/10
Inventor 程翼宇贺庆王毅王学伟李云飞胡兴江葛志伟
Owner TIANJIN TASLY PHARMA CO LTD