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Apoptosis inducers

Inactive Publication Date: 2001-10-25
TAKARA HOLDINGS +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

On the basis of this genes, a programmed death gene protein is subsequently biosynthesized and decomposed the cells per se, thus causing death.

Method used

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  • Apoptosis inducers
  • Apoptosis inducers
  • Apoptosis inducers

Examples

Experimental program
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Effect test

example 1

[0345] 2 kg of thoroughly dried Kjellmaniella crassifolia was ground with a free mill (mfd. by Nara Kikai Seisakusho). The dry powder thus obtained was suspended in 9 1 of 80% ethanol and treated at 80.degree. C. for 2 hours. Then the mixture was filtered through a filter paper to thereby give the residue. This residue was repeatedly washed with ethanol and filtered thrice in the same manner as described above to thereby give the residue after ethanol-washing. This residue was suspended in 40 l of water, treated at 95.degree. C. for 2 hours and filtered. The residue was washed with hot water to thereby give 36 l of an extract containing the sulfated-fucose-containing polysaccharides of Kjellmaniella crassifolia. 1.8 1 of the extract thus obtained was freeze-dried to thereby give 15.4 g of a sulfated-fucose-containing polysaccharide preparation. To the residual extract was added sodium chloride to give a concentration of 0.4 M. Further, 5% cetylpyridinium chloride was added thereto u...

example 2

[0346] 2 kg of thoroughly dried Laminaria japonica was ground with a free mill (mfd. by Nara Kikai Seisakusho). The dry powder thus obtained was suspended in 9 l of 80% ethanol and treated at 80.degree. C. for 2 hours. Then the mixture was filtered through a filter paper to thereby give the residue. This residue was repeatedly washed with ethanol and filtered thrice in the same manner as described above to thereby give the residue after ethanol-washing. This residue was suspended in 40 l of water, treated at 95.degree. C. for 2 hours and filtered. The residue was washed with hot water to thereby give 36 l of an extract containing the sulfated-fucose-containing polysaccharides of Laminaria japonica. To the extract was added sodium chloride to give a concentration of 0.4 M. Further, 5% cetylpyridinium chloride was added thereto until no precipitates were formed any more. Then the precipitates were collected by centrifugation and suspended in 3 l of a 0.3 M aqueous solution of sodium d...

example 3

[0347] Extraction of Laminaria japonica sulfated-fucose-containing polysaccharide mixture:

[0348] 2 kg of thoroughly dried Laminaria japonica was ground with a free mill (mfd. by Nara Kikai Seisakusho). The dry powder thus obtained was suspended in 9 l of 80% ethanol and treated at 80.degree. C. for 2 hours. Then the mixture was filtered through a filter paper to thereby give the residue. This residue was repeatedly washed with ethanol and filtered thrice in the same manner as described above to thereby give the residue after ethanol-washing. This residue was suspended in 36 l of a 0.2 M solution of calcium acetate, treated at 95.degree. C. for 2 hours and filtered. The residue was washed with 4 l of a 0.2 M solution of calcium acetate to thereby give 36 l of an extract containing the sulfated-fucose-containing polysaccharides of Laminaria japonica.

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Abstract

Apoptosis inducers, anticancer drugs and carcinostatic drugs containing sulfated-fucose-containing polysaccharide(s) and / or degradation product(s) thereof, and a method for inducing apoptosis by using sulfated-fucose-containing polysaccharide(s) and / or degradation product(s) thereof as the active ingredient. A degrading enzyme which is useful in the production of the degradation products of sulfated-fucose-containing polysaccharides.

Description

TECHNICAL FIELD TO WHICH THE INVENTION BELONGS[0001] This invention relates to apoptosis inducers, anticancer drugs and carcinostatic drugs which are usable as medicines. It further provides a method for inducing apoptosis which is useful in, for example, clarifying the mechanism of apoptosis and screening apoptosis induction inhibitors. It furthermore provides purified sulfated-fucose-containing polysaccharides and degradation products thereof and-a sulfated-fucose-containing polysaccharide degrading enzyme which is useful in producing sulfated-fucose-containing polysaccharide degradation products and studying the structures thereof.PRIOR ART[0002] In recent years, the style of apoptosis (self-destructive cell death or suicidal cell death) has attracted attention regarding the death of cell tissues.[0003] It is considered that apoptosis is the death inherently programmed in genes, different from necrosis meaning pathological cell death. Namely, some external or internal factors tri...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): C08B37/00A61K31/737C12N9/24C12P19/04C12P19/14
CPCA61K31/737C12P19/14C12Y302/01078C12Y302/01044C12N9/2494A61P35/00A61P43/00A61K31/715
Inventor SAKAI, TAKESHIKITANO, HIDEOYU, FU-GONGNAKAYAMA, SHINJIKOJIMA, KAORUKIMURA, HITOMINAKANISHI, YOSHIKUNIKATAYAMA, KAORUTOMINAGA, TAKANARISHIMANAKA, KAZUOIKAI, KATSUSHIGEKATO, IKUNOSHIN
Owner TAKARA HOLDINGS
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