Kinesin-like motor protein

a kinesin-like, motor protein technology, applied in the direction of bacteria, fungi, peptide sources, etc., can solve the problems of blockage of neural signal transmission, abortive mitosis and chromosomal aneuploidy, and inability to supply the synaptic terminal with these vesicles

Inactive Publication Date: 2002-09-12
INCYTE PHARMA INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Failure to supply the synaptic terminal with these vesicles blocks the transmission of neural signals.
Failure to assemble the mitotic spindle results in abortive mitosis and chromosomal aneuploidy, the latter condition being characteristic of cancer cells.

Method used

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[0168] I cDNA Library Construction

[0169] The COLNNOT16 library was constructed using RNA isolated from sigmoid colon tissue removed from a 62-year-old Caucasian male during a sigmoidectomy and permanent colostomy. Pathology for the associated tumor tissue indicated invasive grade 2 adenocarcinoma. One lymph node contained metastasis with extranodal extension. Patient history included hyperlipidemia, cataract disorder, dermatitis, cholecystectomy, and inguinal hernia repair. Family history included benign hypertension, atherosclerotic coronary artery disease, hyperlipidemia, breast cancer, and prostate cancer.

[0170] Frozen tissue was homogenized and lysed in guanidinium isothiocyanate solution using a Brinkmann Homogenizer Polytron PT-3000 (Brinkmann Instruments, Westbury N.Y.). The lysate was centrifuged over a CsCl cushion to isolate RNA. The RNA was extracted with acid phenol, precipitated with sodium acetate and ethanol, resuspended in RNase-free water, and treated with DNase. Th...

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Abstract

The invention provides a human kinesin-like motor protein (KLIMP) and polynucleotides which identify and encode KLIMP. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating or preventing disorders associated with expression of KLIMP.

Description

[0001] This application is a divisional application of U.S. application Ser. No. 09 / 467,946, filed Dec. 21, 1999, which is a divisional of U.S. application Ser. No. 09 / 162,373, filed Sep. 28, 1998, issued Jan. 11, 2000, as U.S. Pat. No. 6,013,454, entitled KINESIN-LIKE MOTOR PROTEIN, both of which are hereby expressly incorporated by reference.FIELD OF THE INVENTION[0002] This invention relates to nucleic acid and amino acid sequences of a kinesin-like motor protein and to the use of these sequences in the diagnosis, treatment, and prevention of cancer, neurological disorders, and disorders of vesicular transport.BACKGROUND OF THE INVENTION[0003] Translocation of components within the cell is critical for maintaining cell structure and function. Cellular components such as proteins and membrane-bound organelles are transported along well-defined routes to specific subcellular compartments. Intracellular transport mechanisms utilize microtubules which are filamentous polymers that se...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K31/711A61K38/00A61K39/395A61K45/00A61K48/00A61P1/04G01N33/50A61P3/06A61P3/10A61P5/16A61P5/18A61P9/08A61P13/00A61P17/00A61P19/00A61P19/02A61P21/00A61P21/04A61P25/00A61P25/02A61P25/08A61P25/14A61P25/16A61P25/18A61P25/22A61P25/28A61P27/02A61P29/02A61P31/00A61P31/04A61P31/18A61P35/00A61P37/02A61P37/08C07K14/47C07K16/18C12N1/15C12N1/19C12N1/21C12N5/10C12N15/09C12N15/12C12P21/02C12Q1/68C12R1/91G01N33/15G01N33/53G01N33/566
CPCC07K14/47A61P1/04A61P13/00A61P17/00A61P19/00A61P19/02A61P21/00A61P21/04A61P25/00A61P25/02A61P25/08A61P25/14A61P25/16A61P25/18A61P25/22A61P25/28A61P27/02A61P29/02A61P31/00A61P31/04A61P31/18A61P35/00A61P3/06A61P37/02A61P37/08A61P5/16A61P5/18A61P9/08A61P3/10
Inventor TANG, Y. TOMCORLEY, NEIL C.GUEGLER, KARL J.PATTERSON, CHANDRA
Owner INCYTE PHARMA INC
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