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31 results about "Motor protein" patented technology
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Motor proteins are a class of molecular motors that can move along the cytoplasm of animal cells. They convert chemical energy into mechanical work by the hydrolysis of ATP. Flagellar rotation, however, is powered by a proton pump.
Synthetic lethal screen using RNA interference
InactiveUS20050181385A1Modulate activityFew or no effectsSugar derivativesMicrobiological testing/measurementDiseaseDNA damage
The invention provides a method for identifying one or more genes in a cell of a cell type which interact with, e.g., modulate the effect of, an agent, e.g., a drug. For example, an identified gene may confer resistance or sensitivity to a drug, i.e., reduces or enhances the effect of the drug. The invention also provides STK6 and TPX2 as a gene that exhibits synthetic lethal interactions with KSP encoding a kinesin-like motor protein, and methods and compositions for treatment of diseases, e.g., cancers, by modulating the expression of STK6 or TPX2 gene and / or the activity of STK6 or TPX2 gene product. The invention also provides genes involved in cellular response to DNA damage, and their therapeutic uses.
Owner:MERCK SHARP & DOHME CORP
Tetrahydrobenzoisoxazole and tetrahydroindazole derivatives as modulators of the mitotic motor protein
InactiveUS20100022530A1Shorten the progressImprove eliminationBiocideOrganic chemistryMotor proteinStereochemistry
Owner:MERCK PATENT GMBH
Synthetic lethal screen using RNA interference
The invention provides a method for identifying one or more genes in a cell of a cell type which interact with, e.g., modulate the effect of, an agent, e.g., a drug. For example, an identified gene may confer resistance or sensitivity to a drug, i.e., reduces or enhances the effect of the drug. The invention also provides STK6 and TPX2 as a gene that exhibits synthetic lethal interactions with KSP encoding a kinesin-like motor protein, and methods and compositions for treatment of diseases, e.g., cancers, by modulating the expression of STK6 or TPX2 gene and / or the activity of STK6 or TPX2 gene product. The invention also provides genes involved in cellular response to DNA damage, and their therapeutic uses.
Owner:ROSETTA INPHARMATICS INC +1
Compositions and uses of motor protein-binding moieties
InactiveUS20050053591A1Enhancing cellular uptakeEnhancing transmembrane movementPolypeptide with localisation/targeting motifPeptide/protein ingredientsSubcellular localizationMovement protein
The invention provides methods and reagents for efficient transport of macromolecules (such as drug therapeutics including nucleic acids and polypeptides) linked to motor protein-binding moieties (MPBM) intracellularly to a specific subcellular localization. One exemplary MPBP is dynein binding moiety (DBM). Drug therapeutics linked to DBM can be selectively, specifically, and actively transported intracellularly to the nucleus or peri-nuclear region, thus enhancing the uptake of such drug therapeutics into the target subcellular localization.
Owner:INSERT THERAPEUTICS INC
Reagents for the detection of protein phosphorylation in leukemia signaling pathways
InactiveUS20090220991A1Animal cellsImmunoglobulins against animals/humansPhosphodiesteraseLipid kinases
The invention discloses nearly 480 novel phosphorylation sites identified in signal transduction proteins and pathways underlying human Leukemia, and provides phosphorylation site specific antibodies and heavy-isotope labeled peptides (AQUA peptides) for the selective detection and quantification of these phosphorylated sites / proteins, as well as methods of using the reagents for such purpose. Among the phosphorylation sites identified are sites occurring in the following protein types: adaptor / scaffold proteins, acetyltransferases, actin binding proteins, adhesion proteins, apoptosis proteins, calcium-binding proteins, cell cycle regulation proteins, cell surface proteins, channel proteins, chaperone proteins, contractile proteins, cytokine proteins, cytoskeletal proteins, G protein regulators and GTPase activating proteins, guanine nucleotide exchange factors, helicase proteins, immunoglobulin superfamily proteins, inhibitor proteins, protein kinases, lipid kinases, ligases, lipid binding proteins, methytransferases, motor proteins, oxidoreductases, phosphotases, phosphodiesterases, phospholipases, proteases, receptor proteins, trascription factors, transferases, translation / transporter proteins, and ubiquitin conjugating system proteins.
Owner:CELL SIGNALING TECHNOLOGY
Membrane-integrated viral DNA-packaging motor protein connector biosensor for DNA sequencing and other uses
ActiveUS20150267253A1Improve throughputVolume/mass flow measurementFluid pressure measurement by electric/magnetic elementsGene deliveryLipid formation
Compositions and methods are disclosed that exploit the unprecedented modification of double-stranded DNA virus DNA-packaging motor protein connector polypeptides to render them capable of stable incorporation into lipid membranes as a self-assembled homodocamer that forms an aperture through which conductance can occur when an electrical potential is applied across the membrane. The aperture permits use of the modified protein as a biosensor, for dsDNA sequencing, SNP detection and highly sensitive affinity capture and fingerprinting of analytes, and also finds use in electropotential-driven solute translocation, such as for liposomal loading to form therapeutic nanoparticles (e.g., gene delivery) and bioreactors, and for other uses. The aperture can further be used in optical detection of dsDNA or other acceptor labeled analytes in a fluorophore donor labeled single pore channel.
Owner:GUO PEIXUAN
Membrane-integrated viral DNA-packaging motor protein connector biosensor for DNA sequencing and other uses
ActiveUS9234238B2Polypeptide with localisation/targeting motifMicrobiological testing/measurementGene deliveryFluorescence
Compositions and methods are disclosed that exploit the unprecedented modification of double-stranded DNA virus DNA-packaging motor protein connector polypeptides to render them capable of stable incorporation into lipid membranes as a self-assembled homodocamer that forms an aperture through which conductance can occur when an electrical potential is applied across the membrane. The aperture permits use of the modified protein as a biosensor, for dsDNA sequencing, SNP detection and highly sensitive affinity capture and fingerprinting of analytes, and also finds use in electropotential-driven solute translocation, such as for liposomal loading to form therapeutic nanoparticles (e.g., gene delivery) and bioreactors, and for other uses. The aperture can further be used in optical detection of dsDNA or other acceptor labeled analytes in a fluorophore donor labeled single pore channel.
Owner:GUO PEIXUAN
Reagens for the detection of protein acetylation signaling pathways
InactiveUS20090325312A1Immunoglobulins against animals/humansFermentationPhospholipaseProtein Acetylation
The invention discloses 426 novel acetylation sites identified in signal transduction proteins and pathways underlying human protein acetylation signaling pathways, and provides acetylation-site specific antibodies and heavy-isotope labeled peptides (AQUA peptides) for the selective detection and quantification of these acetylated sites / proteins, as well as methods of using the reagents for such purpose. Among the acetylation sites identified are sites occurring in the following protein types: Methyltransferases, Transcription factors, Transcription coactivators, Translation initiation complex proteins, Oxireductases, Protein kinases, RNA binding proteins, Secreted proteins, Transferases, Transporter proteins, Ubiquitin conjugating system proteins, Motor proteins, Phosphotases, Proteases, Phospholipases, Receptor proteins and Vesicle proteins.
Owner:GUO AILAN +4
Tetrahydroquinolines for use as modulators of the mitotic motor protein Eg5
ActiveUS8207345B2Shorten the progressIncrease blockingOrganic chemistryAntineoplastic agentsMedicineMotor protein
Owner:MERCK PATENT GMBH
Nanomotion sensing system and method
InactiveUS8288154B2Small system sizeLittle trainingBioreactor/fermenter combinationsMaterial analysis using sonic/ultrasonic/infrasonic wavesBiological cellHydrogen
A Nanomotion Sensor comprises a micromechanical device for the detection and characterization of specimen motions when they interact with one or an array of cantilevered sensors set in the path of the moving specimen. In particular, the present invention provides a method for direct sensing and characterization of motion, including position, torsion, magnitude and direction of velocity, acceleration, force, torque, as well as binding, which may include hydrogen bonding, electrostatic attractions, hydrophobic effects, dipole interactions, or through other forces through the deflection of a micromechanical cantilever sensor. The present invention is particularly useful for the detection and characterization of the motion of biological cells such as bacteria and sperm, biological systems including motor proteins, cilia of the hearing organ and the lining of the airways in asthmatics, and microfabricated systems.
Owner:ALEGIS MICROSYST
KIF18A inhibitors
PendingCN114302880AOrganic active ingredientsOrganic chemistryImmunologic disordersAutoimmune condition
Amide compounds of formula (I) as defined herein: and compositions containing these compounds, as well as processes for preparing such compounds. Also provided herein are methods of treating disorders or diseases treatable by inhibition of the kinin motor protein KIF18A, such as cancer, psoriasis, atopic dermatitis, autoimmune disease, or inflammatory bowel disease, etc.
Owner:AMGEN INC
Reagents for the Detection of Protein Phosphorylation in Leukemia Signaling Pathways
The invention discloses nearly 123 novel phosphorylation sites identified in signal transduction proteins and pathways underlying human Leukemia, and provides phosphorylation-site specific antibodies and heavy-isotope labeled peptides (AQUA peptides) for the selective detection and quantification of these phosphorylated sites / proteins, as well as methods of using the reagents for such purpose. Among the phosphorylation sites identified are sites occurring in the following protein types: protein kinases, adaptor / scaffold proteins, phosphatase / phospholipases, G proteins / GTPase activating proteins / guanine nucleotide exchange factors, cellular metabolism enzymes, DNA binding proteins, cytoskeletal proteins, cell cycle regulation proteins, proteases, RNA binding proteins, transcription proteins, translation initiation complex proteins, transferases, ubiquitin conjugating system proteins, vesicle proteins, actin binding proteins, apoptosis proteins, chemokine proteins, enzyme proteins extra cellular matrix proteins, helicases, hydrolases, immunoglobin superfamily proteins, inhibitor proteins, isomerases, ligases, lipid binding proteins, methyltransferases, motor proteins, receptor proteins, and chaperone proteins.
Owner:CELL SIGNALING TECHNOLOGY
Kini-3 motor protein and methods for its use
The invention provides isolated nucleic acid and amino acid sequences of KinI-3, antibodies to KinI-3, methods of screening for KinI-3 modulators using biologically active KinI-3, and kits for screening for KinI-3 modulators.
Owner:CYTOKINETICS INC
PCR primer group for detecting pepper mild mottle virus, test kit and application thereof
PendingCN111057796AAvoid False Positive ResultsImprove stabilityMicrobiological testing/measurementMicroorganism based processesCoat proteinQuantitative PCR instrument
The invention discloses a PCR (Polymerase Chain Reaction) primer group for detecting pepper mild mottle virus, the PCR primer group comprises three pepper mild mottle virus (PMMoV) genome motor protein (MP) and coat protein (CP) coding gene partial sequence specific primers and two pepper reference gene Actin specific primers, wherein the three pepper mild mottle virus (PMMoV) genome motor protein(MP) and coat protein (CP) coding gene partial sequence specific primers are PMMoV-F1, PMMoV-F470 and PMMoV-R991 respectively, and the partial sequence specific primers of the MP gene and the CP geneare PMMoV-F470 and PMMoV-R991; the two pepper reference gene Actin specific primers are PeActin-F1 and PeActin-R1093. The PCR amplification result is detected in 1.0%-1.5% agarose, an expensive fluorescent quantitative PCR instrument is not needed, and the PCR primer group has the advantages of being rapid, economical, high in stability, high in accuracy and high in sensitivity.
Owner:GUANGXI ZHUANG AUTONOMOUS REGION ACAD OF AGRI SCI
Protein compound of human cell mesosome, its separation and use thereof
Protein composites of human body cell mesosomem its separation and use are disclosed. The composites consist of at least 129 proteins: 30 cell skeleton proteins, 4 centrosome proteins, 6 vesicular transport related proteins, 6 chromosome regulatory proteins, 2 motor proteins, 3 check point proteins, 7 degradable regulatory proteins, 9 membrane proteins, 12 transcriptional and translational related proteins, 28 protein kinases, 5 mitochondria proteins, 9 molecular chaperone proteins and 7 missing proteins. The process is carried out by culturing, synchronizing and collecting for human body cell, adding hypotonic solution, re-suspending, incubating and expanding collected cell, breaking expanded cell, taking out supernatant, centrifugal separating from density gradient, extracting and purifying protein composite from decontaminate, and separation identifying mesosome protein type. It supplies a pattern system and target protein ezrin and target site.
Owner:UNIV OF SCI & TECH OF CHINA
Molecular motor
InactiveUS7349834B2Control speedBioreactor/fermenter combinationsMaterial nanotechnologyMyosinMolecular motor
A molecular motor in which multiple concentric cylinders (or nested cones) rotate around a common longitudinal axis. Opposing complementary surfaces of the cylinders or cones are coated with complementary motor protein pairs (such as actin and myosin). The actin and myosin interact with one another in the presence of ATP to rotate the cylinders or cones relative to one another, and this rotational energy is harnessed to produce work. The concentration of ATP and the number of nested cylinders or cones can be used to control the rotational speed of the motor. The length of the cylinders can also be used to control the power generated by the motor. In another embodiment, the molecular motor includes at least two annular substrates wherein one annular substrate is coated with a first motor protein and the other annular substrate is coated with a second motor protein. The first and second motor proteins interact with each other to move the second annular relative to the first annular substrate.
Owner:UNITED STATES OF AMERICA
Linkers for characterizing polynucleotides and uses thereof
PendingCN114262735AAvoid empty consumptionImprove sequencing efficiencyMicrobiological testing/measurementDNA/RNA fragmentationPolynucleotideDouble strand
The present invention provides adapters for characterizing polynucleotides and uses thereof. The adaptor comprises {L-S} n or {S-L} n in the direction from the 5'end to the 3 'end; and the L double strand comprises a polynucleotide chain L'linked to S and a complementary chain L "to the L ', the L' comprising a first segment remote from the blocking chain S, the first segment comprising a modification moiety, and a second segment close to the blocking chain S, the second segment comprising a motor protein binding active region, the active region being blocked by the complementary chain L"; the complementary chain L ''comprises a polymer which can be competitively combined with the motor protein to an L'chain. The invention provides a novel Y-shaped adaptor, and the adaptor can be used for greatly avoiding ATP (adenosine triphosphate) empty consumption in nanopore sequencing and remarkably improving the sequencing efficiency.
Owner:QITAN TECH LTD CHENGDU
Monkey encephalic zone virus injection method and applications thereof
InactiveCN108949701AImprove expression efficiencyDoes not activate immune responseMicrobiological testing/measurementViruses/bacteriophagesBiological activationBare surface
The invention relates to a monkey virus injection method and applications thereof, and more specifically relates to a monkey encephalic zone virus injection method, and applications thereof. The monkey encephalic zone virus injection method mainly comprises following steps: virus is coated so as to realize coupling of exposed surface residues on virus housings with magnetic induction proteins, motor proteins, and ATP, and obtaining of modified virus (nanometer robots), and spinal puncture technology is adopted for injection into monkey spinal fluid; and at last, under external magnetic field control, guiding of the modified virus in a target encephalic zone is carried out. Compared with the prior art, the advantages are that: no damage on monkey brain is caused, activation of immunity reaction of monkey brains is avoided, virus release is realized, and at the same time, virus expression efficiency in monkey brains is increased. Under cooperation of magnetic induction proteins and computer controlled magnetic force, the modified virus can be dispersed, expression in encephalic zones of relatively large area is realized, and virus expression efficiency is increased greatly.
Owner:SHENZHEN INST OF ADVANCED TECH CHINESE ACAD OF SCI
Application of Aerolysin Nanopore Channels in Biophosphorylation and Related Enzyme Analysis
ActiveCN111912892BRealize direct identificationHigh sensitivityMaterial electrochemical variablesPhosphorylationEnzyme inhibitor
The invention discloses the application of an aerolysin nanopore channel in the analysis of biological phosphorylation and related enzymes. Specifically, the aerolysin nanopore channel is constructed, and voltage is applied to both ends of the constructed aerolysin nanopore channel, and the analyte or analyte-related probe molecules are added to one end of the detection cell, Driven by the voltage, the analyte passes through the aerolysin nanopore to generate a blocking current signal and the blocking current time. By comparing and analyzing the blocking current signal and the blocking current time, the corresponding molecular weight of the analyte is obtained. Detection information. The invention discloses a new application of the aerolysin nanopore channel, which can be used for the phosphorylation detection and analysis of nucleic acid, polypeptide and protein, does not require DNA motor protein, has high sensitivity, is convenient for detection, and can further realize the Activity analysis and quantitative analysis of various enzymes such as kinases, phosphatases, and enzyme inhibitors, and real-time monitoring of enzyme activities can be realized.
Owner:NANJING UNIV
Protein compound of human cell mesosome, its separation and use thereof
Protein composites of human body cell mesosomem its separation and use are disclosed. The composites consist of at least 129 proteins: 30 cell skeleton proteins, 4 centrosome proteins, 6 vesicular transport related proteins, 6 chromosome regulatory proteins, 2 motor proteins, 3 check point proteins, 7 degradable regulatory proteins, 9 membrane proteins, 12 transcriptional and translational related proteins, 28 protein kinases, 5 mitochondria proteins, 9 molecular chaperone proteins and 7 missing proteins. The process is carried out by culturing, synchronizing and collecting for human body cell, adding hypotonic solution, re-suspending, incubating and expanding collected cell, breaking expanded cell, taking out supernatant, centrifugal separating from density gradient, extracting and purifying protein composite from decontaminate, and separation identifying mesosome protein type. It supplies a pattern system and target protein ezrin and target site.
Owner:UNIV OF SCI & TECH OF CHINA
Kinesin activity detection method
ActiveCN108802401AEasy and fast detectionEasy to detectBiological testingFluorescence/phosphorescenceATP hydrolysisProtein C
The invention discloses a kinesin activity detection method. The method comprises the following steps: (1) ATP (adenosine triphosphate) with different concentrations is mixed with fluorescein / luciferase, and mixtures are obtained; (2) the mixtures are equally divided into two parts and added to a test sample pool and a control sample pool respectively; (3) a buffer solution is injected into the control sample pool, and kinesin is injected into the test sample pool; (4) a detector is started for detecting fluorescence intensity obtained by a reaction of the product ADP in the test sample pool with fluorescein / luciferase and fluorescence intensity of the control sample pool, and a fluorescence intensity-duration curve is obtained; (5) corresponding FATP is measured for ATP with different standard concentrations, and a calibration curve is generated; (6) a Michaelis-Menten curve is drawn; (7) according to a Michaelis-Menten formula, Vmax obtained by fitting is an active parameter for measuring ATP hydrolysis of kinesin; (8) judging activity of kinesin. The activity of kinesin can be detected conveniently and quickly with the detection method.
Owner:YISHANG TOMORROW TECH
Mutated motor protein, application of mutated motor protein and kit comprising mutated motor protein
ActiveCN113684194ALess quantitySlow down the melting speedHydrolasesMicrobiological testing/measurementA-DNACell biology
The invention discloses a mutated motor protein, application of the mutated motor protein and a kit comprising the mutated motor protein. The amount of the motor protein is reduced through specific mutation, the affinity of the motor protein to a DNA template substrate is improved, and the melting speed of the motor protein is slowed down, so that the functional cooperation between the motor protein and DNA polymerase can be accurately regulated and controlled, and thus, the application of the motor protein to nucleic acid amplification, such as an in-vitro simulated isothermal amplification technology based on the mutated motor protein and particularly application to a low-copy DNA template, can achieve the effect of higher detection sensitivity.
Owner:HUNAN YEARTH BIOTECHNOLOGICAL CO LTD
Application of moving point motor protein small molecular inhibitor to inhibition of tumor cell proliferation
ActiveCN102552274BOrganic active ingredientsGroup 5/15 element organic compoundsMammary carcinoma cell lineChemotherapeutic drugs
Disclosed are a small molecule inhibitor Syntelin against kinetochore motor protein CENP-E and use thereof. Provided is a small molecule organic compound that binds to the motor domain of CENP-E motor protein. The binding of the compound to CENP-E inhibits the movement of CENP-E motor protein along microtubules without influencing its interaction with microtubules. The compound can enter the cells to inhibit the function of CENP-E when added to a cell culture medium, leading to partial error in chromosome arrangement and maintaining the spindle checkpoint activity for a long period of time.
Owner:姚雪彪 +1
Process
Provided herein is a method of loading a motor protein onto a polynucleotide adapter. Also provided are polynucleotide adapters and kits comprising such adapters. The adaptor can be used to characterize an analyte, such as a polynucleotide, in a method in which the polynucleotide moves relative to the nanopore.
Owner:OXFORD NANOPORE TECH LTD
Kif18a inhibitors
PendingUS20220289724A1Small sizeOrganic chemistryAntineoplastic agentsAtopic dermatitisBowels diseases
Amide compounds of formula (I): and compositions containing them, and processes for preparing such compounds. Provided herein also are methods of treating disorders or diseases treatable by inhibition of Kinesin Motor Protein KIF18A, such as cancer, psoriasis, atopic dermatitis, an autoimmune disorder, or inflammatory bowel disease, and the like.
Owner:AMGEN INC
Low-virulent vaccine K genom sequence of tomato mosaic
InactiveCN1150322CGenetic stabilityGenetically stableInactivation/attenuationFermentationNucleotideEngineered genetic
The strong genom separated and cloned from tomato mosaic is modified into low-virulent vaccine K genom by point mutation. The nucleotide sequence of its coded replicase and motor protein has the mutation, so it can be used to modify the plant virus genom and prepare genetically engineered vaccine for effectively preventing and treating the viral diseases of plant.
Owner:INST OF MICROBIOLOGY - CHINESE ACAD OF SCI
Tetrahydroquinolines for Use as Modulators of the Mitotic Motor Protein Eg5
Owner:MERCK PATENT GMBH
Kinesin-like motor protein
The invention provides a human kinesin-like motor protein (KLIMP) and polynucleotides which identify and encode KLIMP. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating or preventing disorders associated with expression of KLIMP.
Owner:INCYTE PHARMA INC
Application of moving point motor protein small molecular inhibitor to inhibition of tumor cell proliferation
ActiveCN102552274AOrganic active ingredientsGroup 5/15 element organic compoundsCentromere protein ECell culture media
The invention discloses an application of a moving point motor protein small molecular inhibitor to inhibition of tumor cell proliferation. The moving point motor protein small molecular inhibitor is a compound shown as a formula I or a formula II, and is named Syntelin. As proved by animal experiments, the Syntelin shown as a formula VII can be used for remarkably inhibiting the growth of human breast cancer cells. As proved by further mechanism experiments, the Syntelin shown as the VII formula can be used for inhibiting the walk of a CENP-E (Centromere Protein-E) motor on a micro-tube without influencing the interaction between the CENP-E and the micro-tube after being combined with the CENP-E. When the compound is added into a cell culture medium, the compound can enter cells to inhibit the function of the CENP-E, so that a part of chromosomes are arranged wrongly, and the activity of a spindle detection point is maintained for a long time. The CENP-E small molecular inhibitor Syntelin disclosed by the invention plays an important role in cell biology researches, and a basis can be laid for the research of novel chemotherapy medicaments by using the function of the inhibitor for controlling tumor cell proliferation. The formula I, formula II and formula VII are shown in the specifications.
Owner:姚雪彪 +1
Detection method of motor protein activity
Owner:YISHANG TOMORROW TECH
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