84results about How to "Few or no effects" patented technology

The invention provides a method for identifying one or more genes in a cell of a cell type which interact with, e.g., modulate the effect of, an agent, e.g., a drug. For example, an identified gene may confer resistance or sensitivity to a drug, i.e., reduces or enhances the effect of the drug. The invention also provides STK6 and TPX2 as a gene that exhibits synthetic lethal interactions with KSP encoding a kinesin-like motor protein, and methods and compositions for treatment of diseases, e.g., cancers, by modulating the expression of STK6 or TPX2 gene and/or the activity of STK6 or TPX2 gene product. The invention also provides genes involved in cellular response to DNA damage, and their therapeutic uses.

A speaker system utilizes dipole speaker drivers in conjunction with monopole speaker drivers in a listening area to disperse a surround sound effect to a listener. The dipole speaker drivers are physically mounted on top of the front left and right speakers and are angled in a way that the surround information is delivered to the listener via wall/room reflections. By reflecting the sound off the walls, the system provides a delayed diffuse audio signal from the dipole speakers, enhancing the surround effect.

In a frictional forced power transmission belt A whose back face is reinforced with a short fiber-containing rubber (12) into which short fibers oriented in a single direction are mixed, the short fiber-containing rubber (12) is provided integrally with the back face of the belt so that the direction of orientation of the short fibers forms an angle with respect to the widthwise direction of the belt.

A cheating dummy for repelling deer and similar animals from forbidden site is invented. In addition to cheating ability, the dummy also equipped with sensor for detecting approaching animals and capable of triggering actions such as spreading water toward approaching animals, generating ultra-sound to scare them and even making a gunshot sound to repel them. By combining cheating and scaring functions, the repelling effect is expected to be much better than those devices using only sprinkling water or ultra-sound repelling alone. The cheating dummy is user decoratable by dressing with customized outfits for decoration or increasing cheating ability.

A composition for forming an antireflective coating for use in a photolithography process using exposure light of up to 200 nm comprises a silicon-containing polymer obtained through hydrolytic condensation of a silicon-silicon bond-containing silane compound having formula: R_(6-m)Si₂X_m wherein R is a monovalent hydrocarbon group, X is alkoxy, alkanoyloxy or halogen, and m is 3 to 6. The composition allows the overlying photoresist film to be patterned to a satisfactory profile and has a high etching selectivity relative to organic material so that a substrate can be processed at a high accuracy.

Deposition of a metal-containing reagent solution or suspension onto a conductive substrate by various pad-printing techniques is described. This results in a pseudocapacitive oxide coating, nitride coating, carbon nitride coating, or carbide coating having an acceptable surface area for incorporation into an electrolytic capacitor, such a s one have a tantalum anode.

An anode for an electrolytic capacitor is described. The anode is of a valve metal in powdered form, for example tantalum powder, that has been pressed into a pellet and sintered under a vacuum at high temperatures. Preferably, a poly(alkylene)carbonate binder is used to promote cohesion with the pressed powder body. The binder adds green strength to the pressed body and helps with powder flow before pressing. The poly(alkylene)carbonate binders are superior in that they leave virtually no residual carbon behind when burnt out during the sintering process. The pressed valve metal powder structure is then anodized to a desired voltage in a formation electrolyte to form a continuous dielectric oxide film on the sintered body as well as a terminal lead/anode lead weld extending therefrom.

Ketogenic compositions including a non-racemic mixture of beta-hydroxybutyrate (BHB) enriched with the S-enantiomer are formulated to control ketone body levels in a subject. The non-racemic mixture of BHB is enriched with the S-enantiomer to modulate the effect of ketone bodies in the subject and control the rate at which ketosis is achieved. In some aspects a composition for controlling ketone body level in a subject contains a dietetically or pharmaceutically acceptable carrier and a non-racemic mixture of S-beta-hydroxybutyrate and R-beta-hydroxybutyrate, wherein the non-racemic mixture contains from about 52% to 99% by enantiomeric equivalents of S-beta-hydroxybutyrate enantiomer and from about 48% to about 1% by enantiomeric equivalents of R-beta-hydroxybutyrate enantiomer.

This invention relates to devices for insertion into the mouth for the application of heat or cold to oral tissue to provide a therapeutic effect. The device 10 includes an upper member 11 substantially conforming to a contour of an upper gum line, a lower member 12 substantially conforming to a contour of a lower gum line, a first hinge member 13, and a second hinge member 14, wherein at least one hinge member 13, 14 is configured to exert a compressive force to maintain the upper member 11 substantially in contact with an upper gum and the lower member 12 substantially in contact with a lower gum.

The present disclosure relates to a skin care cosmetic set. The skin care cosmetic set comprises a facial cleanser, a skin care toner, a serum, a whitening cream and a protective emulsion. The facial cleanser comprises an olive extract and a wheat extract; the skin care toner comprises sodium hyaluronate, a hamamelis virginiana extract and betaine; the serum comprises an aloe extract, a soybean extract, EGF moisturizing factors and sodium hyaluronate; the whitening cream comprises cetyl alcohol, vaseline, vitamin E and sodium hyaluronate; the protective emulsion comprises a wheat extract, glycerol, alpha-bisabolol and nano-titanium dioxide, and also discloses an application method thereof. The present invention is used by combinations to form a multi-layer skin care layer, and each skin care layer cooperate with each other, so that the skin care has more comprehensive effect.

In a gaming machine such as a bingo game, there is provided such a gaming machine that game players are effected with realistic sensations and spectators other than game players are involved. The gaming machine is equipped with lottery ball throwing means for throwing a plurality of balls onto a face portion of a cabinet, ball entrance detecting means for detecting whether all the plurality of lottery balls thrown onto the face portion of the cabinet by the lottery ball throwing means enter a plurality of lottery holes, and lottery ball discharging means for discharging the plurality of lottery balls entering any one of the plurality of lottery holes. When it is detected by the ball entrance detecting means that all the plurality of lottery balls thrown by the lottery ball throwing means enter any one of the plurality of lottery holes, the lottery ball discharging means functions to discharge all the plurality of lottery balls after a predetermined time elapses.

The thin film-laminated polyimide film contains a substrate film and a thin film layer formed at least on one surface of the substrate film. The substrate film is made of a polyimide film showing a degree of curl after a heat treatment at 300° C. of not more than 10%. Use of this thin film-laminated polyimide film as a substrate of electronic parts such as solar battery, capacitor and the like exposed to high temperatures prevents easy development of warpage and distortion during production, and can improve quality and yield of electronic parts.

A stereo biauricular audio recording, in which the notes stored in a first channel of the recording are stored in the same sequence in a second channel of the recording but are frequency-shifted by a same value, and a method for processing an audio signal, comprising the steps of: acquiring a set of data adapted to define an audio signal; selecting a frequency shift; generating a first digital audio recording by synthesizing it according to the data set; generating a second digital audio recording by synthesizing it according to the data set and to the frequency shift; selecting a channel of the first audio recording, selecting a channel of the second audio recording, mixing the two channels in a third audio recording which comprises at least two channels.

An anode for an electrolytic capacitor is described. The anode is of a valve metal in powdered form, for example tantalum powder, that has been pressed into a pellet and sintered under a vacuum at high temperatures. Preferably, a poly(alkylene) carbonate binder is used to promote cohesion with the pressed powder body. The binder adds green strength to the pressed body and helps with powder flow before pressing. The poly(alkylene) carbonate binders are superior in that they leave virtually no residual carbon behind when burnt out during the sintering process. The pressed valve metal powder structure is then anodized to a desired voltage in a formation electrolyte to form a continuous dielectric oxide film on the sintered body as well as a terminal lead/anode lead weld extending therefrom.

Disclosed is a method and system for processing the tasks performed by an IC layout processing tool in parallel. In some approaches, the IC layout is divided into a plurality of layout portions and one or more of the layout portions are processed in parallel, where geometric select operations are performed in which data for different layout portions may be shared between different processing entities. One approach includes the following actions: select phase one operation for performing initial select actions within layout portions; distributed regioning action for local regioning; distributed regioning action for global regioning and binary select; count select aggregation for count-based select operations; and select phase two operations for combining results of selecting of internal shapes and interface shapes.

Care and/or make-up cosmetic composition comprising: a liquid continuous fatty Phase structured with at least one structuring polymer (homopolymer or copolymer) having a weight-average molecular mass ranging from 500 to 500 000, containing at least one moiety comprising: at least one polyorganosiloxane group consisting of I to 1 000 organosiloxane units in the chain of the moiety or in the form of a graft, and at least two groups capable of establishing hydrogen interactions, Chosen from ester, amide, sulphonamide, carbamate, thiocarbamate, urea, urethane, thiourea, oxamido, guanidino and biguanidino groups, and combinations thereof, the polymer being solid at room temperature and soluble in the liquid fatty Phase at a temperature of 25 to 250° C., the Said liquid fatty Phase comprising at least one compound capable of reducing the enthalpy of fusion of the structuring polymer, and then the liquid fatty Phase, the structuring polymer and the compound capable of reducing the enthalpy of fusion of the structuring polymer forming a physiologically acceptable medium.

The present invention discloses an electrical push device, comprising a motor (1), a housing (2), and an axially movable push rod (3) provided in the housing (2). A lead screw (4) whose helix rise angle is larger than the locking angle is provided in the push rod (3). A screw nut (5) is provided in the inner end of the push rod (3), and the screw nut and the lead screw (4) constitute a screw pair. The inner segment of the lead screw is provided with a supporting bearing (8). The inner end of the lead screw (4) is connected with the shaft of the motor (1). The electrical push device includes an electromagnet (6) and a brake pair (7). A spring (6b) acting on the moving core (6a) of the electromagnet (6) is provided in the stationary core (6c) of the electromagnet (6). The brake pair (7) includes a rotating brake disc (7a) and a translational movement brake disc (7b). The rotating brake disc (7a) is connected with the shaft of the motor (1). The translational movement brake disc (7b) is connected with the moving core (6a) of the electromagnet (6) and axially moves in a straight line along with the moving core (6a).

We disclose a method of inhibiting activity of adenylyl cyclase or guanylyl cyclase in a mammal by administering to the mammal an amount of a composition effective to inhibit the activity, wherein the composition contains at least one compound selected from the group consisting of structural formulae (Ia) and (Ib) and salts thereof, wherein R1 is —H or has the structure —C(═O)R8; R2 is ═O or has the structure —OC(═O)R9; and R3, R4, R5, R6, and R7 are each independently selected from the group consisting of —H, —NO₂, formula (I), -halogen, —OC(═O)R9, —OR9, —OH, —R8OH, —CH₃, —OC(═O)CH₂Ph, formulae (II), (III), (IV), —OPh, —CF₃, —R8, —C(═O)OR9, -Ph, —R8Ph, formulae (V), (VI), (VII), (VIII), (IX), (X), (XI), (XII), (XIII), (XIV), (XV), (XVI), (XVII), (XVIII), (XIX), (XX), and (XXI), wherein each R8 is independently a linear or branched hydrocarbon group having from 1 to 4 carbon atoms and each R9 is independently a hydrocarbon group having from 1 to 2 carbon atoms. Administering the composition can be used to treat a disease in a mammal mediated by activity of adenylyl cyclase or guanylyl cyclase and effected by a toxin produced by a pathogenic organism or to reduce cyclic AMP or cyclic GMP levels in a mammal in need of reduction thereof. The composition can also be administered to mammalian cells in vitro. The above methods of inhibiting activity of adenylyl cyclase or guanylyl cyclase and treating diseases via such inhibition can be effective without prolonged treatment, have reversible effects, have low or no toxicity, are highly potent, are unlikely to have side effects, do not act on purinergic receptors, or can negate pathogenic toxins independently of whether the pathogenic organism survives.

A hand-held power tool has a drive motor driving a tool and a generator. One or more heating devices having one or more heating elements are provided. The generator supplies the one or more heating devices with energy. A control device controls a power supplied to the one or more heating elements as a function of at least one operating parameter of the drive motor.

The invention relates to methods, compositions, and kits for combination therapy of diabetes and diabetes-related diseases and conditions (e.g., obesity). The invention finds use in patients suffering from or at risk for diabetes or diabetes-related conditions generally, and in patients also suffering from or at risk for fluid retention (e.g., edema, congestive heart failure) and/or in need of synergistic anti-inflammatory, anti-hypertensive, and anti-diabetic effect.