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Kini-3 motor protein and methods for its use

a technology of motor protein and kini-3, which is applied in the field of isolating nucleic acid and amino acid sequences of kini3, can solve the problems of cell cycle arrest in mitosis

Inactive Publication Date: 2005-03-10
CYTOKINETICS INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Benefits of technology

[0018] Also provided are modulators of the target protein including agents for the treatment of cellular proliferation, including cancer, hyperplasias, restenosis, cardiac hypertrophy, immune disorders and inflammation. The agents and compositions provided herein can be used in variety of applications which include

Problems solved by technology

Defects in function of these proteins would be expected to result in cell cycle arrest in mitosis.

Method used

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  • Kini-3 motor protein and methods for its use
  • Kini-3 motor protein and methods for its use
  • Kini-3 motor protein and methods for its use

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Embodiment Construction

[0028] I. Definitions

[0029]“ADP” refers to adenosine diphosphate and also includes ADP analogs, including, but not limited to, deoxyadenosine diphosphate (dADP) and adenosine analogs. “Antibody” refers to a polypeptide substantially encoded by an immunoglobulin gene or immunoglobulin genes, or fragments thereof which specifically bind and recognize an analyte (antigen). The recognized immunoglobulin genes include the kappa, lambda, alpha, gamma, delta, epsilon and mu constant region genes, as well as the myriad immunoglobulin variable region genes. Light chains are classified as either kappa or lambda. Heavy chains are classified as gamma, mu, alpha, delta, or epsilon, which in turn define the immunoglobulin classes, IgG, IgM, IgA, IgD and IgE, respectively. The term antibody also includes antibody fragments either produced by the modification of whole antibodies or those synthesized de novo using recombinant DNA methodologies.

[0030] An “anti-KinI-3” antibody is an antibody or ant...

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PUM

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Abstract

The invention provides isolated nucleic acid and amino acid sequences of KinI-3, antibodies to KinI-3, methods of screening for KinI-3 modulators using biologically active KinI-3, and kits for screening for KinI-3 modulators.

Description

CROSS-REFERENCE TO RELATED APPLICATION [0001] The present application is a continuation-in-part of U.S. Ser. No. 09 / 675,227, filed Sep. 29, 2000, which is incorporated by reference in its entirety for all purposes.FIELD OF THE INVENTION [0002] The invention provides isolated nucleic acid and amino acid sequences of KinI-3 (Accession number AL353662), methods of detecting KinI-3 and screening for KinI-3 modulators using biologically active KinI-3, and kits for screening for KinI-3 modulators. BACKGROUND OF THE INVENTION [0003] The kinesin superfamily is an extended family of related microtubule motor proteins. It can be classified into at least 8 subfamilies based on primary amino acid sequence, domain structure, velocity of movement, and cellular function. This family is exemplified by “true” kinesin, which was first isolated from the axoplasm of squid, where it is believed to play a role in anterograde axonal transport of vesicles and organelles (see, e.g., Goldstein, Annu. Rev. Ge...

Claims

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Application Information

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IPC IPC(8): G01N33/50A61K45/00A61P1/00A61P9/00A61P17/00A61P19/00A61P35/00A61P37/02A61P43/00C07K14/47C12N1/15C12N1/19C12N1/21C12N5/10C12N9/14C12N15/09C12Q1/42G01N33/15G01N37/00
CPCY10S977/914C12N9/14A61P1/00A61P9/00A61P17/00A61P19/00A61P35/00A61P37/02A61P43/00
Inventor BERAUD, CHRISTOPHEGUO, JUNFREEDMAN, RICHARDPATEL, UMESHDAVIES, KATHERINE
Owner CYTOKINETICS INC
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