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Apparatus and method for coating implantable devices

a technology of implantable devices and apparatus, applied in the direction of packaging foodstuffs, blood vessels, packaged goods, etc., can solve the problems of affecting the patient's health, affecting the patient's overall health, and causing adverse or toxic side effects for the patient,

Inactive Publication Date: 2004-09-16
PACETTI STEPHEN D
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Mechanical intervention via stents has reduced the rate of restenosis; restenosis, however, is still a significant clinical problem.
In order to provide an efficacious concentration to the treated site, systemic administration of such medication often produces adverse or toxic side effects for the patient.
Non-volatile solvents evaporate very slowly from the composition causing coating defects such as inconsistency in the coating thickness and formation of "cob webs" or "pool webs" between the stent struts.
However, not all drugs are stable at elevated temperatures.
Volatile solvents have the tendency to evaporate very quickly from the composition resulting in a coating which has a powdered consistency and adheres poorly to the surface of the stent.

Method used

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  • Apparatus and method for coating implantable devices
  • Apparatus and method for coating implantable devices

Examples

Experimental program
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Embodiment Construction

Embodiments of the Pressure Chamber

[0013] Referring to FIG. 1, there is illustrated a pressure chamber 10 defining a workspace 12 for depositing a composition on a stent 14 for forming a coating. A chamber opening (number omitted) can be provided for allowing a user to gain access into workspace 12. A hatch 16 can be placed over the chamber opening for tightly sealing the opening during the deposition process. The size of workspace 12 needs to be large enough so as to enclose a support assembly 18, such as a mandrel, for adequately supporting stent 14 during the coating process. Workspace 12 can be large enough so as to support any suitable number of support assemblies 18 and stents 14.

[0014] In one embodiment, support assembly 18 can be connected to a first motor assembly 20A for rotation of support assembly 18 along the central, longitudinal axis x of stent 14. A second motor assembly 20B can be additionally provided for translational movement of support assembly 18 in a linear di...

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Abstract

A method of forming a coating for an implantable medical device, such as a stent, is provided which includes applying a composition to the device in an environment having a selected pressure. An apparatus is also provided for coating the devices. The apparatus comprises a chamber for housing the device wherein the pressure of the chamber can be adjusted during the coating process.

Description

[0001] This is a Continuation of U.S. Ser. No. 09 / 872,816, filed on May 31, 2001, allowed.[0002] 1. Field of the Invention[0003] This invention relates to an apparatus and method for coating implantable devices such as stents.[0004] 2. Description of the Background[0005] Stents act as scaffoldings, functioning to physically hold open and, if desired, to expand the wall of the passageway. Typically, stents are capable of being compressed, so that they can be inserted through small cavities via catheters, and then expanded to a larger diameter once they are at the desired location. Mechanical intervention via stents has reduced the rate of restenosis; restenosis, however, is still a significant clinical problem. Accordingly, stents have been modified to perform not only as a mechanical scaffolding, but also to provide biological therapy.[0006] Biological therapy can be achieved by medicating the stents. Medicated stents provide for the local administration of a therapeutic substance a...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): B05B13/02B05B15/12B05D1/02B05D3/04
CPCA61L31/10A61L31/16A61L2300/00B05D3/0493B05B15/12B05D1/02B05D3/0486B05B13/0235B05B16/00
Inventor PACETTI, STEPHEN D.
Owner PACETTI STEPHEN D
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