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Methods of modulating a mammalian cytokine

a technology of cytokine and mammalian cytokine, which is applied in the direction of dna/rna fragmentation, antibacterial agents, peptide/protein ingredients, etc., can solve the problems of disease that strikes about 1% of the population and cannot be cured, and achieves the effects of increasing the count of platelets, modulating blood cell counts, and increasing the count of total white blood cells

Inactive Publication Date: 2005-09-15
SCHERING CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Benefits of technology

[0012] In another aspect, the present invention provides a method of modulating blood cell counts comprising administering an effective amount of an agonist or antagonist of IL-33; and the above method wherein the IL-33 agonist increases the counts of total white blood cells; neutrophils; lymphocytes; or eosinophils; as well as the above method wherein the IL-33 antagonist increases the count of platelets; and the above method wherein the IL-33 antagonist decreases the counts of total white blood cells; neutrophils; lymphocytes; or eosinophils.

Problems solved by technology

The disorder strikes about 1% of the population and cannot be cured.

Method used

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  • Methods of modulating a mammalian cytokine
  • Methods of modulating a mammalian cytokine
  • Methods of modulating a mammalian cytokine

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I. General Methods.

[0092] Standard methods in biochemistry and molecular biology are described (see, e.g., Maniatis, et al. (1982) Molecular Cloning, A Laboratory Manual, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.; Sambrook and Russell (2001) Molecular Cloning, 3rd ed., Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.; Wu (1993) Recombinant DNA, Vol. 217, Academic Press, San Diego, Calif.). Standard methods also appear in Ausbel, et al. (2001) Current Protocols in Molecular Biology, Vols. 1-4, John Wiley and Sons, Inc. New York, N.Y., which describes cloning in bacterial cells and DNA mutagenesis (Vol. 1), cloning in mammalian cells and yeast (Vol. 2), glycoconjugates and protein expression (Vol. 3), and bioinformatics (Vol. 4).

[0093] Methods for protein purification including immunoprecipitation, chromatography, electrophoresis, centrifugation, and crystallization are described (Coligan, et al. (2000) Current Protocols in Protein Science, Vol. 1, ...

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Abstract

Provided are methods of modulating cytokine activity, e.g., for the purpose of treating immune and inflammatory disorders, including tumors and cancer. Also provided are methods of administering agonists or antagonists of IL-33 and IL-33 receptor.

Description

[0001] This filing is a U.S. patent application which claims benefit of U.S. Provisional Patent Application No. 60 / 545,730, filed Feb. 17, 2004, which is incorporated herein by reference.FIELD OF THE INVENTION [0002] The present invention relates generally to uses of mammalian cytokines. More specifically, the invention discloses methods of using IL-33, and a receptor for IL-33. BACKGROUND OF THE INVENTION [0003] The immune system protects individuals from infective agents, e.g., bacteria, multi-cellular organisms, as well as cancers. This system includes several types of lymphoid and myeloid cells such as monocytes, macrophages, dendritic cells (DCs), eosinophils, T cells, B cells, and neutrophils. These lymphoid and myeloid cells often produce signaling proteins known as cytokines. Immune response includes inflammation, i.e., the accumulation of immune cells systemically or in a particular location of the body. In response to an infective agent or foreign substance, immune cells s...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K38/00A61K38/20A61K48/00C07K14/54C07K16/24C07K16/28
CPCA61K38/00A61K2039/505C07K16/244G01N33/6869C07K2317/76A61K38/20C07K16/2866A61P1/00A61P1/04A61P11/06A61P17/00A61P17/06A61P19/02A61P25/00A61P25/02A61P25/28A61P29/00A61P31/00A61P31/04A61P31/06A61P31/12A61P31/16A61P31/18A61P31/22A61P33/00A61P33/02A61P33/06A61P35/00A61P35/02A61P37/00A61P37/02A61P37/08A61P43/00A61P7/00Y02A50/30
Inventor SCHMITZ, JOCHENOFT, MARTINKASTELEIN, ROBERT
Owner SCHERING CORP
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