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Bioadhesive compositions and biomedical electrodes containing them

a bioadhesive composition and composition technology, applied in the direction of organic conductors, conductive materials, conductive materials, etc., can solve the problems of likely deleterious changes in adhesive and electrical properties, and achieve the effects of enhancing the bioadhesive properties of the composition, enhancing the mechanical strength of the composition, and increasing the water activity of the composition

Inactive Publication Date: 2005-11-03
FIRST WATER
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

"The patent text describes a new bioadhesive composition that has specific properties suitable for use as a pressure-sensitive adhesive. The composition has a water activity of 0.4 to 0.9, an elastic modulus at 1 rad / s of 700 to 15,000 Pa, an elastic modulus at (100 rad / s) of 2000 to 40,000 Pa, and a viscous modulus at 1 rad / s of 400 to 14,000 Pa. The composition also has a low impedance at 10 Hz of less than 10 ohms. The water activity is important for preventing water loss and maintaining the adhesive's performance. The composition can be used to create adhesive films with good adhesion and peel strength. The patent text also describes a method for measuring the water activity and the elastic and viscous moduli of the composition. Overall, the patent text provides a technical solution for creating a bioadhesive with optimal properties for adhesive applications."

Problems solved by technology

When water is lost from the hydrogel both the adhesive and electrical properties are likely to change deleteriously.

Method used

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  • Bioadhesive compositions and biomedical electrodes containing them
  • Bioadhesive compositions and biomedical electrodes containing them
  • Bioadhesive compositions and biomedical electrodes containing them

Examples

Experimental program
Comparison scheme
Effect test

example 2

[0072] In 20 parts of polyethylene glycol diacrylate (pEG600) (product of 5 UCB Chemicals marketed under the trade name designation of Ebacryl 11) 6 parts of 1-hydroxycyclohexyl phenyl ketone (product of Ciba and marketed under the trade name designation of Irgacure 184) were dissolved. (This solution is designated solution A) (XL / PI). Separately 58 parts of the potassium salt of 3-sulphoproylacrylate (SPA) (product of Raschig) were dissolved in 58 parts distilled water to form solution D. A further solution designated solution E consisted of 42 parts water, 58 parts of the sodium salt of 2-acrylamido-2-methylpropane sulphonic acid (NaAMPS) (a product of the Lubrizol Corporation marketed as a 58% aqueous solution under the trade name LZ2405A). Mixtures of solutions D and E in the ratios 100:0, 90:10, 60:40, 50:50, 40:60, 10:90 and 0:100 were made to form pre-gel solutions. To 100 parts of each of these pre-gel solutions, 0.17 parts of solution A and 3 parts potassium chloride were a...

example 3

[0074] To 57 parts of a 58% solution of the sodium salt of 2-acrylamido-2-methylpropane sulphonic acid (NaAMPS) (LZ2405A) 10 parts of a 58% solution of the potassium salt of 3-sulphopropyl acrylate (SPA) were added alone with 5 parts potassium chloride and stirred until the potassium chloride has dissolved. This solution was then mixed with 30 parts glycerol for 30 minutes. To the latter solution were added 0.15 parts of a solution containing 20 parts of polyethylene glycol diacrylate (pEG600) (product of UCB Chemicals marketed under the trade name designation of Ebacryl 11) in which 6 parts of 1-hydroxycyclohexyl phenyl ketone (product of Ciba and marketed under the trade name designation of Irgacure 184) were dissolved. The so-formed pre-gel solution was then cured as in Example 1. The impedance of the resulting gel, measured as described in Example 1, was 83 Ohms. Good skin adhesion properties were obtained for this gel. The impedance of a similar gel made from 67 parts of a 58% ...

example 4

[0075] The method of Example 3 was repeated with 1 part citric acid being added with the potassium chloride. The impedance of a similar gel (denoted 4B in Table 3) made from 67 parts of a 58% solution of the sodium salt of 2-acrylamido-2-methylpropane sulphonic acid but no SPA had an impedance of 96 Ohms demonstrating again that the addition of SPA reduces the impedance. From the data summarised in TABLE 3, however, it is seen that addition of citric acid also gives rise to a reduction in impedance, and the effect is surprisingly large for a gel with SPA and NaAMPS. The adhesion to skin and reusability characteristics for this gel of Example 4 containing citric acid and SPA were better than the gel described in Example 3.

TABLE 3Example3A3B4A4BNaAMPS67576757(58% soln)SPA010010(58% soln)Glycerol30303030Citric Acid0011Crosslinker / 0.150.150.150.15PhotoinitiatorImpedance105859661(ohms)

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Abstract

Bioadhesive Compositions which comprise a hydrophobic polymer wherein the concentration of the polymer at the surface of the adhesive is greater than its concentration in the bulk of the adhesive are described; and biomedical electrodes, fixation products and wound dressings containing them.

Description

[0001] This invention relates to bioadhesive compositions, particularly electrically conductive hydrogel compositions having bioadhesive properties. The invention further relates to biomedical skin electrodes incorporating such hydrogel bioadhesive compositions that are electrically conductive. BACKGROUND [0002] Biomedical skin electrodes are widely used in a variety of situations, whenever for example it is required to establish an electrical connection between the surface of the body of the patient and external medical equipment for transmission of electrical signals. [0003] Modern medicine uses many medical procedures where electrical signals or currents are received from or delivered to a patient's body. The interface between medical equipment used in these procedures and the skin of the patient is usually some sort of biomedical electrode. Such electrodes typically include a conductor which must be connected electrically to the equipment, and a conductive medium adhered to or o...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61B5/0408A61F13/00A61L15/16A61L26/00A61L15/58A61L24/00A61L24/04A61L24/06A61N1/04C08F220/38C08F220/58C09J133/00C09J133/06C09J133/14C09J133/26C09J141/00C09J201/00
CPCA61B5/04087A61F13/0253A61N1/0496A61N1/0468A61N1/046A61N1/0456A61N1/0452A61N1/0428A61L24/06A61L15/58A61L15/585A61L24/0021A61L24/043C08L3/02C08L33/14C08L33/26A61B2562/0215A61B2562/0217A61B5/259
Inventor MUNRO, HUGH SEMPLEYASIN, MOHAMMED
Owner FIRST WATER
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