Dissolvable film composition

a film composition and dissolvable technology, applied in the direction of drug compositions, bandages, plant/algae/fungi/lichens ingredients, etc., can solve the problems of affecting the amount of active that is actually delivered within the skin, affecting the effect of active delivery, and often diluted active amounts

Inactive Publication Date: 2006-01-05
BEVACQUA ANDREW J +4
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0009] The present invention provides a system, a kit and methods for delivering an effective amount of a labile active to the skin, comprising a composition comprising an e

Problems solved by technology

A common problem in cosmetic compositions has been the effective delivery of actives to the skin.
Since cosmetic compositions often have numerous ingredients to make it cosmetically acceptable, the amount of active is often diluted.
Moreover, the presence of other ingredients can impede the amount of active that is actually delivered within the skin.
Even if ingredients in the cosmetic compositions do not impede effective delivery of the active to the skin, the active may fail to successfully adhere to the skin to deliver essential actives to the skin.
Moreover, many actives are unstable in cosmetic vehicles.
For example, Polyphenone E, the active component of

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0044] A water-soluble polymeric film of the present invention incorporating a labile active may be formulated as provided below in Table 2. Table 2 provides the weight percentages of the elements of the composition prior to drying the film.

TABLE 2IngredientCTFA namePercentMethocel K4M PremiumCellulose Ether2.00%1,3-Butylene Glycol1,3 Butylene Glycol2.00%Green Tea PolyphenolPolyphenol 0.5%Deionized WaterPurified WaterQ / s

example 2

[0045] The composition shown below in Table 3 provides an example of an alternative embodiment of the present invention providing a first layer of adhesive water-soluble polymeric films incorporating labile actives and a second layer of water-soluble polymeric film adjacently adhered to the first layer. The patch is intended primarily for whitening of the skin. The weight percentages of the elements indicate the amount in the final, dried composition.

[0046] An example of an activator or additive composition is provided in Table 4 below. The compositions in Table 3 and Table 4 combined provide the system and kit of the present invention.

TABLE 3INVENTIVE POLYMERIC FILM COMPOSITIONCOMPONENTFUNCTIONCHEMICAL NAMEPERCENTAGEADHESIVE WATER SOLUBLEFILM FORMING LAYERCONTAINING LABILE ACTIVESPVPAdhesive film layerPolyvinylpyrrolidone47.558900POLYVINYL ALCOHOLAdhesive film layerPolyvinyl alcohol4.750000WATER (AQUA PURIFICATA)Water1.797700PURIFIEDCAMELLIA SINENSIS LEAFLabile activeGREEN TEA E...

example 3

[0048] This example illustrates the use and performance of the system of the present invention.

[0049] This is a controlled study which consists of two months of product use. The test site is the face of selected female panelists. The women are instructed to refrain from using any treatment products on the test site during the test period except for the test products provided. Skin evaluations are carried out before treatment (baseline), and two, four, and eight weeks during the course of treatment.

[0050] The women are instructed to apply 2 patches of the composition described in Table 3 above, to each side of the face once a day in the morning. The patch is pressed firmly onto the skin for 15 to 30 seconds. The tab is gently peeled back, leaving the blue active film on the face. A dab of additive composition described in Table 4 hereinabove is applied to each patch, and blended into the skin for 10 to 15 rotations until the film dissolves and is absorbed into the skin. On the day ...

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Abstract

A system, a kit and methods for delivering an effective amount of a labile active to the skin, comprising a composition comprising an effective amount of a labile active agent incorporated into a water-soluble polymeric film and an additive composition capable of dissolving the water-soluble polymeric film.

Description

[0001] The following invention claims priority under 35 USC 119e of U.S. provisional application 60 / 581,842 filed Jun. 22, 2004.FIELD OF THE INVENTION [0002] The present invention relates to a dissolvable film composition for application to the skin. In particular, the present invention relates to a dissolvable film composition that provides stable actives for delivery to the skin. BACKGROUND OF THE INVENTION [0003] A common problem in cosmetic compositions has been the effective delivery of actives to the skin. Since cosmetic compositions often have numerous ingredients to make it cosmetically acceptable, the amount of active is often diluted. Moreover, the presence of other ingredients can impede the amount of active that is actually delivered within the skin. Even if ingredients in the cosmetic compositions do not impede effective delivery of the active to the skin, the active may fail to successfully adhere to the skin to deliver essential actives to the skin. [0004] Moreover, m...

Claims

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Application Information

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IPC IPC(8): A61K36/82A61K9/70
CPCA61K8/345A61K8/35A61K8/39A61K8/731A61K8/8129A61K8/8176A61K2800/882A61K9/0014A61K9/7007A61Q17/04A61Q19/02A61Q19/08A61K8/0216A61K8/97A61K8/9711A61K8/9728A61K8/9761A61K8/9789A61K8/9794A61P17/00
Inventor BEVACQUA, ANDREW J.LENTINI, PETER J.KEELER, TRACY N.ZECCHINO, JULLES R.VASSILIOU, PAULINE
Owner BEVACQUA ANDREW J
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