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Nutritional supplement compositions

a technology of nutritional supplement and composition, applied in the field of nutritional supplement composition, can solve the problems of few successful treatments available for people with low-dose sex, and achieve the effect of reducing the risk of overdosing

Inactive Publication Date: 2006-04-27
THE RES FOUND OF STATE UNIV OF NEW YORK
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0010] As disclosed herein, prolonged treatment with a low dose of morphine can result the continued positive effects of morphine such as nitric oxide release, without the need to escalate morphine dosages with time to achieve the same beneficial effects. In addition, the use of low doses of morphine can allow mammals to experience the beneficial effects of morphine, while not experiencing possible negative effects of morphine (e.g., addiction or powerful analgesia). Likewise, providing mammals with a morphine precursor such as reticuline can allow mammals to experience the beneficial effects of morphine, while not experiencing possible negative effects of morphine (e.g., addiction or powerful analgesia). For example, using a morphine precursor such as reticuline can allow patients to receive a low dose of morphine indirectly with a reduced risk of overdosing.

Problems solved by technology

In many cases, few, if any, successful treatments are available for these people.
In addition, the use of low doses of morphine can allow mammals to experience the beneficial effects of morphine, while not experiencing possible negative effects of morphine (e.g., addiction or powerful analgesia).

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0015] This document provides methods and materials related to nutritional supplement compositions containing one or more of the following compounds: arginine, selenium, morphine, morphine precursors (e.g., tyrosine, tyramine, phenyl alanine, 3,4 dihydroxyphenyl pyruvate, dihydroxyphenyl acetaldehyde, dopamine, L-DOPA, reticuline, norlaudanosoline, salutaridine, thebaine, or codeine), morphine-6β-glucuronide, inhibitors of morphine synthesis or activity, or inhibitors of dopamine synthesis. Such nutritional supplement compositions can be used to treat diseases, to reduce inflammation, or to restore normal function.

[0016] In one embodiment, this document provides compositions containing morphine, morphine precursors, morphine-6β-glucuronide, or combinations thereof. Morphine or morphine-6β-glucuronide can be formulated into compositions designed to deliver a low dose of morphine or morphine-6β-glucuronide to a mammal. Typically, a low dose of morphine is a dose that is below that wh...

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Abstract

Dietary supplement compositions containing one or more compounds such as arginine, selenium, calcium, calcium sources, morphine precursors (e.g., reticuline), morphine, and morphine-6β-glucuronide are provided.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS [0001] This application claims the benefit of U.S. Provisional Application Ser. No. 60 / 714,769, filed Sep. 6, 2005 and U.S. Provisional Application Ser. No. 60 / 615,048, filed Oct. 1, 2004, each of which is incorporated by reference in its entirety into this specification.STATEMENT AS TO FEDERALLY SPONSORED RESEARCH [0002] Funding for the work described herein was provided by the federal government, which may have certain rights in the invention.BACKGROUND [0003] 1. Technical Field [0004] The document relates to nutritional supplement compositions. For example, this document relates to nutritional supplement compositions containing one or more compounds such as arginine, selenium, calcium, calcium sources, morphine precursors (e.g., reticuline), morphine, and morphine-6β-glucuronide. [0005] 2. Background Information [0006] Many people suffer from conditions such as depression, neurodegenerative diseases, pro-inflammatory diseases, autoimmune di...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K31/7052A61K31/485A61K31/198A61K33/04
CPCA23V2002/00A23L33/10A61K31/485A61K31/7052A61K33/04A61K33/06A61K31/198A61K31/472A61K31/194A61K45/06A61K2300/00A23V2200/322A23V2250/30A23V2250/0606A23V2250/1626A61P9/10A61P17/00A61P19/02A61P25/00A61P25/16A61P25/18A61P25/22A61P25/24A61P25/28A61P25/30A61P29/00A61P43/00
Inventor STEFANO, GEORGE B.CADET, PATRICKMANTIONE, KIRK J.ZHU, WEI
Owner THE RES FOUND OF STATE UNIV OF NEW YORK
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