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Degradable polymers and methods of preparation thereof

a technology of degradable polymers and polymers, applied in the field of degradable polymers and methods of preparation thereof, can solve the problems of premature loss of polymer structure and function, trauma to patients, and interference with normal body function

Inactive Publication Date: 2006-09-28
CALIFORNIA INST OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0029] thereby degrading the polymer in the patient, wherein the polymer substantially degrades in the presence of both the first and second trigger, and the polymer does not substantially degrade in the presence of either the first or second trigger alone.

Problems solved by technology

However, non-biodegradable polymeric implants are often temporary and require removal from the body, which can traumatize the patient.
While biodegradable polymers are often employed when temporary implants are needed, these devices often degrade too quickly, so that polymer structure and function is prematurely lost, or too slowly, so that prolonged polymer / implant presence interferes with normal body function.

Method used

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  • Degradable polymers and methods of preparation thereof
  • Degradable polymers and methods of preparation thereof
  • Degradable polymers and methods of preparation thereof

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Embodiment Construction

1. Definitions

[0050] For convenience, before further description of the present invention, certain terms employed in the specification, examples, and appended claims are collected here. These definitions should be read in light of the remainder of the disclosure and understood as by a person of skill in the art.

[0051] The term “acyl” is art-recognized and refers to a group represented by the general formula hydrocarbylC(O)—, preferably alkylC(O)—.

[0052] The term “acylamino” is art-recognized and refers to an amino group substituted with an acyl group and may be represented, for example, by the formula hydrocarbylC(O)NH—.

[0053] The term “acyloxy” is art-recognized and refers to a group represented by the general formula hydrocarbylC(O)O—, preferably alkylC(O)O—.

[0054] The term “alkoxy” refers to an alkyl group having an oxygen attached thereto. Representative alkoxy groups include methoxy, ethoxy, propoxy, tert-butoxy and the like.

[0055] The term “alkoxyalkyl” refers to an alk...

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Abstract

The present invention provides polymers which substantially degrade in the presence of one or more triggers, preferably light energy or hydrogen peroxide, but does not substantially degrade in the absence of one or more triggers.

Description

RELATED APPLICATIONS [0001] This application claims the benefit of U.S. Provisional Patent Application 60 / 638,511, filed Dec. 22, 2004, the specification of which is incorporated by reference herein.BACKGROUND OF THE INVENTION [0002] Implantable surgical devices such as surgical fasteners, clips, staples, partitions, stents, and sutures are typically employed in surgical procedures to hold body tissue together, to separate body tissue, and / or to promote the healing and joining of the tissue. Such surgical devices are often made from synthetic non-biodegradable and biodegradable or bioerodible polymers. Synthetic absorbable multifilament sutures such as Dexon, Vicryl, and Polysorb, commercially available from Davis & Geck (Danbury, Conn.), Ethicon, Inc. (Somerville, N.J.), and United States Surgical Corporation (Norwalk, Conn.), respectively, are well known in the industry. An advantage of non-biodegradable implants is that they generally retain their structural integrity and propert...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): C08G75/00C08G79/08C08G79/02
CPCA61K6/08A61L17/10A61L17/145A61L27/14A61L27/34A61L27/50A61L27/58A61L31/10A61L31/148C08G63/68C08G63/688C08L101/16A61K6/884
Inventor DAVIS, MARK E.WRIGHT, KENNETH W.ZEIDAN, RYAN K.
Owner CALIFORNIA INST OF TECH
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