Method to determine the risk for side effects of an SSRI treatment in a person
a risk and treatment technology, applied in the direction of drug compositions, nervous disorders, biochemistry apparatus and processes, etc., can solve the problems of affecting sexual function, headache, nausea, and nausea after starting treatment with ssri, and achieve the effect of increasing the risk of side effects of ssri treatmen
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[0038] Treatment Protocol
[0039] 122 patients with major depression were treated for 8 weeks with paroxetine. All subjects were 65 years of age or older and had been free of major medical problems for at least 3 months. At screening, all met DSM-IV criteria for major depression (single or recurrent), had Mini Mental State Examination scores above the 25th percentile for their age, and had a Hamilton Depression Rating Scale 17-item (HDRS-17) score of at least 18. Patients were excluded for clinically significant laboratory abnormalities, drug or alcohol abuse, psychosis, recent suicide attempt, and psychiatric conditions other than major depression, or treatment with antidepressant medications within 7 days of commencing the study.
[0040] Initial treatment was with 20 mg of paroxetine (two 10 mg capsules) given each evening. On day 14, doses were increased to 30 mg of paroxetine once daily. At days 28 and 42, dose increases to 40 mg of paroxetine were allowed if the patient had a Cli...
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