Method and device for monitoring and improving patient-ventilator interaction

Abstract

Method and apparatus for non-invasively determining the time onset (Tonset) and end (Tend) of patient inspiratory efforts. A composite pressure signal is generated comprising the sum of an airway pressure signal, a gas flow pressure signal obtained by applying a gain factor (Kf) to a signal representing gas flow rate and a gas volume pressure signal obtained by applying a gain factor (Kv) to a signal representing volume of gas flow. Kf and Kv values are adjusted to result in a desired linear trajectory of composite pressure signal baseline in the latter part of the exhalation phase. The current composite pressure signal is compared with (i) selected earlier composite pressure signal values and / or (ii) value expected at current time based on extrapolation of composite pressure signal trajectory at specified earlier times and / or (iii) the current rate of change in the composite pressure signal with a selected earlier rates of change. The differences obtained by the comparison are compared with selected threshold values. Tonset is identified when at least one of the differences exceeds the threshold values.

Description

REFERENCE TO RELATED APPLICATION [0001] This application claims priority under 35 USC 119(e) from U.S. Provisional Patent Application No. 60 / 391,594 filed Jun. 27, 2002.FIELD OF INVENTION [0002] This invention relates to assisted mechanical ventilation. BACKGROUND TO THE INVENTION [0003] With assisted ventilation (e.g. assist volume cycled ventilation, pressure support ventilation and proportional assist ventilation) ventilator cycles are triggered by the patient and are intended to coincide with patient's inspiratory effort. In practice, however, the ventilator cycle never begins at the onset of patient's inspiratory effort (trigger delay) and the end of the ventilator's inflation phase only rarely coincides with the end of inspiratory effort (cycling-off errors). FIG. 1 provides an example. The bottom channel is transdiaphragmatic pressure (measured by esophageal and gastric catheters) and reflects true patient inspiratory effort. As may be seen, ventilator cycle was triggered sev...

AI Technical Summary

Benefits of technology

[0065] generating a signal that causes the ventilator to cycle off when time elapsed since onset of inspiratory effort exceeds a specified fraction of TTOT.

[0071] generating a signal that causes the ventilator to cycle off when inspiratory flow in the current inflation phase decreases below said average flow value.

[0108] One aspect of the current invention is to minimize the cycling-off errors either by directly identifying the end of patient's inspiratory effort or by insuring that the ventilator's inflation phase does not extend beyond the physiologic limit of the duration of inspiratory effort.

Problems solved by technology

Trigger delay is often so marked that some efforts completely fail to trigger the ventilator (ineffective efforts, e.g. third effort, FIG. 1).

There are, accordingly, two inspiratory efforts within a single inflation phase and there is an additional ineffective effort during the ventilator's expiratory phase.

Non-synchrony is believed to cause distress, leading to excessive sedation and sleep disruption, as well as errors in clinical assessment of patients since the respiratory rate of the ventilator can be quite different from that of the patient.

Thus, if the response of the ventilator is poor, triggering may not occur immediately when the triggering criteria are reached.

This component of trigger delay can, however, still be excessive if the user sets an unnecessarily high threshold.

This setting may be because of lack of sufficient expertise, or because there was excessive baseline noise at some point, which necessitated a high threshold to avoid auto-triggering.

This delay is related to the fact that expiratory resistance is usually high in ventilated patients and expiratory time is frequently too short to allow lung volume to return to FRC (functional residual capacity) before the next effort begins.

Cycling-off errors result from the fact that, except with Proportional Assist Ventilation, current ventilator modes do not include any provision that links the end of ventilator cycle to end of the inspiratory effort of the patient.

While this method may yield reasonably accurate results in the intended application (treatment of obstructive sleep apnea patients with non-invasive BiPAP), a number of considerations suggest that its use in critically ill, intubated, ventilated patients may not provide accurate results:

Thus, changes in inspiratory flow profile cannot be used to reflect similar changes in alveolar pressure.

The use of flow to infer end of effort during the inflation phase is accordingly not plausible.

This considerably decreases the sensitivity and specificity of flow pattern as a marker of inspiratory effort.

However, a change in flow trajectory also results in changes in volume and Paw trajectories.

However, it is not possible to prospectively identify that a trajectory change took place in a timely manner, for the sake of triggering the ventilator.

There is always uncertainty with extrapolation, particularly with non-linear functions where the exact function is not known and, even more so, when the signal is noisy, as the flow signal commonly is (due to cardiac artefacts or secretions).

Otherwise, false triggering will occur frequently.

Thus, in the average mechanically ventilated patient the use of flow trajectory to identify Tonset is not likely to result in a significant improvement over the current approach of waiting for flow to become inspiratory.

Even an experienced eye, with the benefit of hindsight, cannot distinguish between a true trajectory change and some flow artefact.

In summary, the use of flow to identify respiratory phase transitions is entirely unsuitable for identification of inspiratory to expiratory transitions during mechanical ventilation in critically ill patients (because of the highly variable Paw during inflation), and has poor sensitivity and specificity for identifying expiratory to inspiratory transitions in these patients because of the frequent use of active exhalation valves, the presence of variable time constant during expiration and the often marked abnormalities in elastance and resistance.

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