Antigen of hybrid M protein and carrier for group a streptococcal vaccine

a streptococcal vaccine and hybrid m protein technology, applied in the field of recombinant vaccines, can solve the problems of generally non-immunogenic or inadequate immunogenic antigens, and achieve the effect of optimally raising the desired antigen, optimizing the exposure of the epitope, and promoting the conformation of the fragment of m protein
US20070053937A1Inactive Publication Date: 2007-03-08UNIV OF TENNESSEE RES FOUND
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Patent Information

Authority / Receiving Office
US · United States
Patent Type
Applications(United States)
Current Assignee / Owner
UNIV OF TENNESSEE RES FOUND
Publication Date
2007-03-08
Estimated Expiration
Not applicable · inactive patent

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Abstract

Recombinant hybrid streptococcal M protein antigens are provided which elicit protective antibodies against Group A streptococci and prevent rheumatic fever. Recombinant hybrid genes that encode the antigen are provided. Vaccine compositions and methods of administering the compositions are provided to elicit immunity against Group A streptococci.
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Description

CROSS-REFERENCE TO RELATED APPLICATIONS

[0001] This application is a continuation of U.S. patent application Ser. No. 10 / 141,627, filed May 7, 2002, now allowed; which is a continuation of U.S. patent application Ser. No. 08 / 914,479, filed Aug. 19, 1997 (U.S. Pat. No. 6,419,932); which is a continuation of U.S. patent application Ser. No. 08 / 409,270, filed Mar. 23, 1995, now abandoned; which is a continuation of U.S. patent application Ser. No. 07 / 945,860, filed Sep. 16, 1992, now abandoned. These applications are incorporated herein by reference in their entireties.FIELD OF INVENTION

[0002] The present invention relates broadly to the field of recombinant vaccines. The vaccines are directed to preventing Group A streptococcal infections, which may otherwise result in rheumatic fever. BACKGROUND OF THE INVENTION

[0003] Acute rheumatic fever (ARF) is the major cause of heart disease in children around the world. The disease is rampant in developing countries where prevalence rates of...

Claims

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