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Transdermal Therapeutic System

a transdermal therapeutic system and transdermal coating technology, applied in the field of transdermal therapeutic systems, can solve the problems of increasing the complexity of packaging, and increasing the cost of manufacturing and disposing of packaging, so as to reduce packaging costs, reduce packaging costs, and reduce packaging thickness

Inactive Publication Date: 2007-07-19
BEIER CORNELIA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0003] The cover layers used in conventional transdermal therapeutic systems are films made from acetal, acrylate, acrylonitrile butadiene styrene, acrylonitrile (methyl methacrylate) copolymer, acrylonitrile copolymer, ethylene ethyl acrylate, ethylene methyl acrylate, ethylene vinyl acetate, ethylene vinyl acetate copolymer, ethylene vinyl alcohol polymer, ionomers, nylon (polyamide), nylon copolymer, polybutylene, polycarbonate, polyester, polyethylene terephthalate, thermoplastic polyester copolymer, polyethylene copolymer (high-density), polyethylene (high molecular weight, high-density), polyethylene (intermediate molecular weight, high-density), polyethylene (linear low-density), polyethylene (low density), polyethylene (medium density), polyethylene oxide, polyimide, polypropylene, polypropylene (coated), polypropylene (oriented), polystyrene, polyurethane, polyvinyl acetate, polyvinyl chloride, polyvinylidene chloride, and / or styrene acrylonitrile, which, if required, may have been metallized or pigmented. They serve to stabilize the active substance-containing system and protect it against external influences. The cover layer is impermeable to the active substances and therefore prevents the active substance from diffusing to the outside.
[0042] The membrane, which usually consists of inert polymers, in particular on the basis of polypropylene, polyvinyl acetate, polyamide, ethylene vinyl acetate copolymers and / or silicon, can have an effect controlling the release of the active substance, depending on pore size.

Problems solved by technology

As the thickness of the aluminum coating increases, environmental incompatibility and the costs incurred in manufacturing and disposing of the packaging increases.
In practice, however, total impermeability can not be attained.
As a result, however, the packaging of the transdermal therapeutic system becomes more complicated and significantly more expensive.
Highly odorous substances such as amines and polymer monomers which are released during storage from the active substance or the pressure-sensitive adhesive layer can not be eliminated at all or only partially by using this method.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 2

[0116] Manufacture of a cover layer that is impermeable to the active substances or removable protective layer of a transdermal therapeutic system, wherein such layers have been coated with a polymer support containing absorbing agents and channel-forming agents:

[0117] First, the components polymer, channel-forming agents, and absorbing agents are mixed at an elevated temperature, and preferably, the polymer and the channel-forming agents are premixed.

[0118] Portions of the resulting mixture are packaged for subsequent processing or processed directly. For that purpose, the mixture is applied in a molten state, e.g. in an extruder or by using other suitable mixing and / or dosing devices, the basic variations of which, for example, are already commonly used in the application of hot melt adhesives. Afterwards, the mixture is applied, for example by means of nozzles or rollers, onto the film which already forms or will form a part of the active substance-containing composite, in a de...

example 3

[0119] Composition of the Mixture:

Polypropylene70 percent by weightPolyethylene Glycol10 percent by weightMolecular Sieve 4 Å20 percent by weight

example 4

[0120] Composition of the Mixture:

Polypropylene35 percent by weightPolyethylene Glycol12 percent by weightMolecular Sieve 4 Å53 percent by weight(Baylith ® Powder)

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Abstract

This present invention concerns a cover layer that is impermeable to the active substances and / or a removable protective layer of a transdermal therapeutic system, comprising a thermoplastic film which either directly contains the absorbing agents and channel-forming agents or is coated with a polymer support (thermoplast) containing these substances. The polymer support can either be applied over the entire surface of the film or in patterns, directly during production. The thermoplastic film that is used and the polymer support can be made from either the same or different materials.

Description

RELATED APPLICATIONS [0001] This application claims priority to, and is a continuation of, U.S. patent application Ser. No. 10 / 433,373, filed Sep. 11, 2003, which is a 371 of PCT / EP01 / 14280, filed Dec. 5, 2001, which claims the benefit of priority from German patent application number DE 10060852.3, filed Dec. 6, 2000, the contents of which are incorporated herein by reference in their entireties.SUMMARY OF THE INVENTION [0002] This present invention concerns a cover layer that is impermeable to the active substances or a removable protective layer of a transdermal therapeutic system containing absorbing agents and channel-forming agents. [0003] The cover layers used in conventional transdermal therapeutic systems are films made from acetal, acrylate, acrylonitrile butadiene styrene, acrylonitrile (methyl methacrylate) copolymer, acrylonitrile copolymer, ethylene ethyl acrylate, ethylene methyl acrylate, ethylene vinyl acetate, ethylene vinyl acetate copolymer, ethylene vinyl alcoho...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K9/70A61K31/70
CPCA61K9/7023Y10S602/90Y10T428/14Y10T428/1414Y10T428/1452Y10T428/1471Y10T428/1405Y10T428/254Y10T428/1486Y10T428/25Y10T428/1438Y10T428/252
Inventor BEIER, CORNELIAKIBELE, RALF
Owner BEIER CORNELIA
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