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Rapid analyte measurement assay

a technology for analyte measurement and assays, applied in the field of analyte detection methods, can solve the problems of inaccuracy of measurement, and the inability of conventional systems relying on electrical components within a meter to indirectly estimate the temperature of samples, so as to reduce the time and achieve the level of accuracy in the measurement of analytes

Active Publication Date: 2008-01-03
ABBOTT DIABETES CARE INC
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The present invention is about devices, systems, and methods for quickly measuring analytes in small-volume samples. The invention uses square wave voltammetry (SWV) to measure the concentration of target analytes, which can complete the assay process in a matter of seconds. The invention also compensates for interferences from factors that may affect the assay, such as hematocrit and temperature. The invention can measure glucose concentrations in blood samples with a volume of 0.6 μL or less, and can be used in biosensors or disposable test strips. The secondary redox couples in the system act as internal standards to compensate for changes in the sample's physical properties. Overall, the invention provides a level of accuracy and speed in measuring analytes that cannot be achieved with conventional techniques.

Problems solved by technology

Another aspect of the invention is the ability to compensate for influences from factors which may interfere with the assay process and thus result in an inaccurate measurement.
Conventional systems that rely on electrical components within a meter to indirectly estimate sample temperature cannot guarantee the same degree of accuracy.

Method used

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Embodiment Construction

[0030]While the details of the present invention are described and illustrated in the context of measuring glucose concentration in a blood sample, such application is not intended to be limiting but merely exemplary of the present invention.

[0031]As mentioned above, embodiments of the present invention include the use of SWV methodology to reduce the measurement time for determining the concentration of glucose in volumes, e.g., small volumes, of blood applied to an electrochemical cell. In particular, a devices, systems and method of embodiments of the present invention involve the application of a potential waveform to an electrochemical cell configured for glucose concentration determination, where in certain embodiments the applied potential waveform includes a square wave (see FIG. 1A) superimposed on top of a potential step function (see FIG. 1B). The resulting potential waveform is shown in FIG. 1C, where EP is the magnitude of the cathodic and anodic potential pulses away f...

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Abstract

The present the invention provides methods, devices and systems for rapidly measuring analytes within a biological sample.

Description

FIELD OF THE INVENTION[0001]The present invention is related to methodologies for the detection of analytes in biological samples.BACKGROUND[0002]Analyte concentration determination in biological fluids is of ever increasing importance. Such assays find use in a variety of applications and settings, including clinical laboratory testing, home testing, etc., where the results of such testing play a prominent role in the diagnosis and management of a variety of disease conditions. Common analytes of interest include glucose for diabetes management, cholesterol for monitoring cardiovascular conditions, and creatinine, creatine, urea and the like. In response to this growing importance of analyte concentration detection, a variety of analyte detection protocols and devices for both clinical and home use have been developed.[0003]One type of method that is employed for analyte detection is an electro-chemical-based method. In such methods, a sample of a substance to be tested, e.g., a bi...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): G01F1/64G01N33/487G01N27/26
CPCG01N27/3274
Inventor TONKS, SIMON
Owner ABBOTT DIABETES CARE INC
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