Polymorphic forms of nateglinide

Abstract

Provides are crystalline forms of nateglinide, labeled Forms A, C, D, F, G, I, J, K, L, M, N, O, P, Q, T, U, V, Y, α, β, γ, δ, ε, σ, θ and Ω, processes for their preparation and processes for preparation of other crystalline forms of nateglinide. Also provided are their pharmaceutical formulations and methods of administration.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS

[0001] This application is a divisional application of U.S. patent application Ser. No. 10 / 622,905, filed Jul. 18, 2003, claims the benefit of U.S. provisional application Ser. Nos. 60 / 396,904 filed Jul. 18, 2002; 60 / 413,622, filed Sep. 25, 2002; 60 / 414,199, filed Sep. 26, 2002; 60 / 423,750, filed Nov. 5, 2002; 60 / 432,093, filed Dec. 10, 2002; 60 / 432,962, filed Dec. 12, 2002; 60 / 442,109, filed Jan. 23, 2003; 60 / 449,791, filed Feb. 24, 2003; and 60 / 479,016, filed Jun. 16, 2003, the contents of all of which are incorporated herein by reference.FIELD OF THE INVENTION

[0002] The present invention relates to the solid state chemistry of nateglinide.BACKGROUND OF THE INVENTION

[0003] Nateglinide, known as (−)-N-(trans-4-isopropylcyclohexanecarbonyl)-D-Phenylalanine, has the following structure and characteristics:FormulaC19H27NO3Molecular Weight317.42Exact Mass317.199093CompositionC 71.89% H 8.57% N 4.41% O 15.12%

[0004] Nateglinide is marketed as STARLIX, w...

Examples

example 1

This Example Illustrates Preparation of Various Forms of Nateglinide from a Solution

[0174]Nateglinide (5 g) was placed into an erlenmeyer flask and heated to the specified temperature. The solvent was added in 1-ml portions (in some cases, the solvent was added in 5-ml portions) until a clear solution was obtained. If a clear solution was not obtained after addition of 150 ml of the solvent, the hot mixture was filtered.

[0175]The clear solution was left to crystallize at room temperature. If crystallization did not happen or was poor, the solution was refrigerated at 3° C. The precipitate was filtered off (at RT or at 5° C. depending on the temperature of the crystallization), weighed and divided into 2 equal parts. One part was dried at 50° C. under reduced pressure (20-30 mmHg) to constant weight (±0.01 g) for about 3-10 hours. Details are presented in Table IV.

TABLE IVData on crystallization of NTG from a single solventL / S,T,TimeTimeFormFormSolventml / g° C.RT, h3° C., hWetDryXylen...

example 2

This Example Illustrates Trituration of Nateglinide Form H and U in Various Solvents

[0176]Nateglinide (5 g) was placed into an Erlenmeyer flask. Solvent was added in 1-ml portions to prepare a stirrable mixture. The flask was stirred with a magnetic stirrer at room temperature. A solid was filtered off at room temperature, weighted, and divided into 2 equal parts. One part was dried at 55° C. under 20-30 mm / Hg pressure to constant weight (±0.01 g).

[0177]Details are presented in Tables V and VI.

TABLE VData on trituration of NTG with a single solventStartL / SFormFormFormSolventml / gTime, hwetdryHMeOH1.224TG + BHEtOH1.224DBHIPA1.224GG + BHn-1.223FBPrOHHn-1.424IBuOHHMeCN4.825PH + PHNM426εH + PHNMP0.824JβHDMF1.225KHDMA1.226CBHDME1.424VHHDioxane2.224δδHTHF0.823δδHDCM1.825YYHCHCl3125QQ + BHDCE1.824Q + HQ + H

TABLE VIData on trituration of NTG with a single solventStartL / SFormFormFormSolventml / gTime, hwetdryUAcOH1.824H + SH + SUMeOH1.224ααUEtOH1.624B + αB + αUIPA1.824G + SG + SUn-1.425FBPrOHUn...

example 3

This Example Illustrates Absorption of Solvent Vapors by Nateglinide

[0178]Nateglinide (3.50 g) was added to a polypropylene can and weighed. The can was introduced into a bigger polypropylene container containing a solvent, and stored at room temperature. The can was removed from the container and weighed (Wfinal). The can content was divided into 2 portions. One portion was dried at a temperature of 55° C. and a pressure of 20-30 mmHg to constant weight (±0.01 g). Details are presented in Table VII.

TABLE VIIData on absorption of solvent vapors with NTG Form HFormFormNTG W, gBrutto, gSolventTime, dWfinalΔwetdry3.5015.77EtOH416.290.52DB3.5015.94MeOH416.120.18OO3.5015.78Acetone415.860.08HH3.4951.86DCM451.900.04Y—3.5015.27Water415.290.02HHLegend.Brutto - starting weight of the can with NTG;Wfinal - final weight of the can with NTG after the exposure;Δ - overweight

CROSS-REFERENCE TO RELATED APPLICATIONS

[0001] This application is a divisional application of U.S. patent application Ser. No. 10 / 622,905, filed Jul. 18, 2003, claims the benefit of U.S. provisional application Ser. Nos. 60 / 396,904 filed Jul. 18, 2002; 60 / 413,622, filed Sep. 25, 2002; 60 / 414,199, filed Sep. 26, 2002; 60 / 423,750, filed Nov. 5, 2002; 60 / 432,093, filed Dec. 10, 2002; 60 / 432,962, filed Dec. 12, 2002; 60 / 442,109, filed Jan. 23, 2003; 60 / 449,791, filed Feb. 24, 2003; and 60 / 479,016, filed Jun. 16, 2003, the contents of all of which are incorporated herein by reference.FIELD OF THE INVENTION

[0002] The present invention relates to the solid state chemistry of nateglinide.BACKGROUND OF THE INVENTION

[0003] Nateglinide, known as (−)-N-(trans-4-isopropylcyclohexanecarbonyl)-D-Phenylalanine, has the following structure and characteristics:FormulaC19H27NO3Molecular Weight317.42Exact Mass317.199093CompositionC 71.89% H 8.57% N 4.41% O 15.12%

[0004] Nateglinide is marketed as STARLIX, w...

Examples

example 1

This Example Illustrates Preparation of Various Forms of Nateglinide from a Solution

[0174]Nateglinide (5 g) was placed into an erlenmeyer flask and heated to the specified temperature. The solvent was added in 1-ml portions (in some cases, the solvent was added in 5-ml portions) until a clear solution was obtained. If a clear solution was not obtained after addition of 150 ml of the solvent, the hot mixture was filtered.

[0175]The clear solution was left to crystallize at room temperature. If crystallization did not happen or was poor, the solution was refrigerated at 3° C. The precipitate was filtered off (at RT or at 5° C. depending on the temperature of the crystallization), weighed and divided into 2 equal parts. One part was dried at 50° C. under reduced pressure (20-30 mmHg) to constant weight (±0.01 g) for about 3-10 hours. Details are presented in Table IV.

TABLE IVData on crystallization of NTG from a single solventL / S,T,TimeTimeFormFormSolventml / g° C.RT, h3° C., hWetDryXylen...

example 2

This Example Illustrates Trituration of Nateglinide Form H and U in Various Solvents

[0176]Nateglinide (5 g) was placed into an Erlenmeyer flask. Solvent was added in 1-ml portions to prepare a stirrable mixture. The flask was stirred with a magnetic stirrer at room temperature. A solid was filtered off at room temperature, weighted, and divided into 2 equal parts. One part was dried at 55° C. under 20-30 mm / Hg pressure to constant weight (±0.01 g).

[0177]Details are presented in Tables V and VI.

TABLE VData on trituration of NTG with a single solventStartL / SFormFormFormSolventml / gTime, hwetdryHMeOH1.224TG + BHEtOH1.224DBHIPA1.224GG + BHn-1.223FBPrOHHn-1.424IBuOHHMeCN4.825PH + PHNM426εH + PHNMP0.824JβHDMF1.225KHDMA1.226CBHDME1.424VHHDioxane2.224δδHTHF0.823δδHDCM1.825YYHCHCl3125QQ + BHDCE1.824Q + HQ + H

TABLE VIData on trituration of NTG with a single solventStartL / SFormFormFormSolventml / gTime, hwetdryUAcOH1.824H + SH + SUMeOH1.224ααUEtOH1.624B + αB + αUIPA1.824G + SG + SUn-1.425FBPrOHUn...

example 3

This Example Illustrates Absorption of Solvent Vapors by Nateglinide

[0178]Nateglinide (3.50 g) was added to a polypropylene can and weighed. The can was introduced into a bigger polypropylene container containing a solvent, and stored at room temperature. The can was removed from the container and weighed (Wfinal). The can content was divided into 2 portions. One portion was dried at a temperature of 55° C. and a pressure of 20-30 mmHg to constant weight (±0.01 g). Details are presented in Table VII.

TABLE VIIData on absorption of solvent vapors with NTG Form HFormFormNTG W, gBrutto, gSolventTime, dWfinalΔwetdry3.5015.77EtOH416.290.52DB3.5015.94MeOH416.120.18OO3.5015.78Acetone415.860.08HH3.4951.86DCM451.900.04Y—3.5015.27Water415.290.02HHLegend.Brutto - starting weight of the can with NTG;Wfinal - final weight of the can with NTG after the exposure;Δ - overweight

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