Apoptosis-Modulating Protein Therapy for Proliferative Disorders and Nanoparticles Containing the Same

US20090018078A1Inactive Publication Date: 2009-01-15BOARD OF RGT UNIV OF NEBRASKA
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Patent Information

Authority / Receiving Office
US · United States
Current Assignee / Owner
BOARD OF RGT UNIV OF NEBRASKA
Publication Date
2009-01-15
Estimated Expiration
Not applicable · inactive patent

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Abstract

Protein containing nanoparticles and methods of use thereof for the treatment of proliferative disorders are disclosed.
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Description

[0001] This application claims priority under 35 U.S.C. §119(e) to U.S. Provisional Application, 60 / 958,830 filed Jul. 9, 2007, the entire content of which is incorporated herein by reference.FIELD OF THE INVENTION

[0002] The present invention relates to the fields of drug delivery and proliferative disorders. More specifically, the invention provides p53 protein containing nanoparticles and methods of use thereof for the treatment of diseases associated with aberrant p53 functions, including without limitation, restenosis, tumor growth, for modulating drug effects which are dependent on p53 functional activity (e.g., drug resistance in cancer therapy), and altered artherogenesis.BACKGROUND OF THE INVENTION

[0003] Several references and patent documents are cited throughout this application to better define the state of the art to which the invention pertains. Each of these citations is incorporated by reference herein as though set forth in full.

[0004] Gene delivery using non-viral syste...

Claims

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