Stabilization and ionic triggering of nitric oxide release

Abstract

Provided is a method for producing nitric oxide that employs an ion exchange resin. Also provided is a method for producing nitric oxide that combines a salt with a gel or cream. A method is provided for producing nitric oxide that combines a Ph adjuster with a diazeniumdiolate-containing compound or composition.

Description

[0001]This application claims priority of U.S. Provisional Patent Application Ser. No. 60 / 490,218, which is herein incorporated by reference in its entirety.FIELD OF THE INVENTION[0002]This invention relates to a method for producing nitric oxide. More specifically, this invention relates to using ionic exchange resins in the production of nitric oxide. This invention is also directed to using Ph adjusters in combination with diazeniumdiolate-containing compounds (NONOates) to produce nitric oxide. The invention is further directed to producing nitric oxide by mixing a cream with a salt.BACKGROUND OF THE INVENTIONIonic Exchange Resins[0003]Ionic exchange resins are known. Most modern ionic exchange resins, or ionic exchangers, consist of a synthetic polymer backbone or matrix to which is attached a functional group that gives each ionic exchanger its specific properties. Ionic exchange resins are produced in various physical forms depending on the end use for the resin. Most commonl...

AI Technical Summary

Benefits of technology

[0022]The present invention includes an embodiment that uses an ion exchange resin, and that embodiment allows for ionic triggering of the release or production of nitric oxide. An additional advantage of the present invention is that it provides a gel or cream delivery system for producing or delivering nitric oxide to a target region or specific location. An additional advantage to using a cream or gel delivery system is that the surface area of the delivery vehicle provides an advantage over other prior art methods for delivering nitric oxide.

[0023]Nitric oxide is a well-known compound that is a colorless gas at room temperature.

[0024]Ionic exchange resins are well-known. An ionic exchange resin is typically a polymer with electrically-charged sites at which one anion may replace another. Synthetic ionic exchange resins are usually cast as porous beads with a considerable external and porous surface area where ions can attach. Anionic exchange resins and cationic exchange resins are two specific types of ionic exchange resins. Anionic exchange resins are exchange resins that have a plurality of positively-charged sites, and cationic exchange resins are ionic exchange resins that have a plurality of negatively-charged sites.

[0025]Counter ions are the ions that form ion pairs with the charged sites on an ionic exchange resin. More specifically, when an ionic exchange resin is a cationic exchange resin, the counter ion is a cation that forms an ion pair with a negatively-charged site on the exchange resin. When the ionic exchange resin is an anionic exchange resin, the counter ion is an anion that forms an ion pair with the positively-charged site on the anionic exchange resin.

[0026]A salt is generally known as a compound that is formed when the hydrogen atom of an acid is replaced by a metal or a metal equivalent.

[0027]A Ph adjuster is a composition that either increases or decreases the Ph of a reaction medium.

Problems solved by technology

Later on, it was discovered that sulfonated coal is a relatively effective ionic exchange material, but such materials are fragile and are useful only under restricted operating conditions.

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