Antimicrobial composition and methods of making and using same

a technology of composition and antimicrobial composition, applied in the field of antimicrobial composition and methods of making and using same, can solve the problems of composition showing lethality toward other microorganisms such as viruses, fungi, molds, yeasts, etc., and achieves the effect of low toxicity and high efficacy

Inactive Publication Date: 2010-04-08
NEXT SCI IP HLDG PTY LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0014]Without wishing to be bound by theory, the combination of high tonicity (high osmolar concentration) and large amounts of surfactant is believed to induce bacterial membrane leakage, leading to cell lysis. While the ingredients used to prepare such compositions typically are ineffective as bactericides when used at concentrations commonly employed in commercial products, an appropriately for

Problems solved by technology

In addition to being lethal toward a wide spectrum of gram positive and gram negative bacteria, the compositi

Method used

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Examples

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Embodiment Construction

[0035]A composition according to the present invention can result, after no more than 10 minutes residence time, in at least 6 log (99.9999%) reductions in the number of bacteria in an entrenched biofilm. Embodiments of the composition which are non-toxic if ingested can result, after no more than 10 minutes residence time, in at least 4 log (99.99%) reductions in the number of bacteria in an entrenched biofilm. The foregoing compare to commercially available bactericides, where non-toxic versions show less than a 1 log (90%) reduction and toxic versions show 1 to 2 log (90-99%) reductions, with the latter exhibiting a much higher level of toxicity levels than any embodiment of the presently provided composition.

[0036]The composition can contain as few as three ingredients: water, the dissociation product(s) of at least one acid, and at least one surfactant, each of which generally is considered to be biocompatible. The dissociation product(s) of one or more alkali metal salts of or...

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Abstract

An aqueous composition adapted to kill bacteria in both planktonic and biofilm states is lethal toward a wide spectrum of gram positive and gram negative bacteria as well as other microbes. The composition, which is slightly to moderately acidic, includes a significant amount of one or more surfactants and large amounts of osmotically active solutes. The composition can be applied directly to a site of bacterial growth. Even when the bacteria is in biofilm form, the surfactant component(s) begin to kill the bacteria before the macro-molecular matrix is removed or dislodged from the site.

Description

CROSS-REFERENCE TO RELATED APPLICATION[0001]This application claims the benefit of U.S. provisional application No. 61 / 103,214 filed 6 Oct. 2008, the entire disclosure of which is incorporated herein by reference.BACKGROUND INFORMATION[0002]Bacteria is found virtually everywhere and is responsible for a significant amount of disease and infection. Ridding surfaces of bacteria is desirable to reduce human exposure. Bacteria in normal environments have developed self preservation mechanisms and are therefore extremely difficult to remove and / or eradicate.[0003]Bacteria can be found in both planktonic and biofilm forms. In the biofilm form, they interact with surfaces and form surface colonies which adhere to a surface and continue to grow. The bacteria produce exopolysaccharide (EPS) and / or extracellular-polysaccharide (ECPS) macromolecules that keep them attached to the surface and form a protective film that is effective against many forms of attack. Protection most likely can be at...

Claims

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Application Information

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IPC IPC(8): A01N25/04
CPCA01N25/30A01N37/36A01N41/04A01N33/12A01N2300/00
Inventor MYNTTI, MATTHEW F.
Owner NEXT SCI IP HLDG PTY LTD
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