Mixtures For Forming Porous Constructs

a technology of porous constructs and mixtures, applied in the field of preparation of mixtures, can solve the problems of difficult mixing, inability to separate the respective constituents of the combination, and inability to meet the requirements of the patient,

Inactive Publication Date: 2010-04-22
DEPUY PROD INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, water and organic solvents can gradually evaporate if the combination is stored for several days without commencing additional processing steps, and such evaporation can result in the segregation of the respective constituents of the combination.
However, organic solvents may be undesirably toxic, expensive, combustible, and / or volatile, while the high viscosity of polyethylene glycol may make mixing difficult.
There exist other drawbacks to such methods that justify a need for additional techniques for the preparation of mixtures that can be used to form constructs having uniform or otherwise controllable porosity.

Method used

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  • Mixtures For Forming Porous Constructs
  • Mixtures For Forming Porous Constructs
  • Mixtures For Forming Porous Constructs

Examples

Experimental program
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Effect test

example 1

Stability of Inventive Mixtures

[0031]A first mixture comprising titanium metal powder, NaCl extractable material, and glycerol solution was prepared. A second mixture comprising titanium metal powder, NaCl and reverse osmosis (RO) water was also prepared, and both mixtures were placed under a fume hood in separate open containers. Both mixtures were left undisturbed under the fume hood for a period of four days. As shown in FIG. 1, the mixture that was prepared using RO water did not remain well-mixed following the four-day period; the circled portion of FIG. 1 clearly shows the segregation of NaCl particles from the particles of titanium. In contrast, the mixture that was prepared using glycerol solution remained well-mixed following the same four-day period, with no visible segregation of the salt particles from the metal powder (circled portion of FIG. 2). A third mixture, comprising titanium metal powder, NaCl extractable material, and glycerol solution, was prepared and placed ...

example 2

Porosity of Sintered Bodies

[0033]Three separate mixtures were prepared. The first mixture comprised a combination of titanium powder, NaCl, and 25% by volume glycerol solution as a homogenizing agent. The second mixture included the same ingredients but used a 50% glycerol solution instead of a 25% solution, and the third mixture also included titanium powder and NaCl, but made use of reverse osmosis (RO) water as the homogenizing agent rather than glycerol. Each of the three mixtures were subsequently compacted, exposed to aqueous solvent to remove the NaCl particles, and sintered to form a porous body. The three samples were otherwise alike with respect to titanium powder particle size, salt particle size, green porosity, the total quantity of homogenizing agent combined with the titanium powder and NaCl, compaction pressure, sintering temperature, and sintering time.

[0034]The porosity of each of the three samples was measured by an imaging process using Image-Pro®Plus software (M...

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Abstract

Provided are methods comprising at least one metal powder with an extractable material and a composition comprising a polyol, a hydrophilic polymer, or both in order to form a mixture in which the metal powder and the extractable material assume respective positions. The composition functions as a homogenizing agent that allows the mixture to remain well-mixed for extended periods of time under ambient conditions. Also provided are green bodies and porous constructs, including implants, that are made in accordance with the disclosed methods. The green bodies and porous constructs have a substantially uniform porosity that is at least partially attributable to the ability of the composition to maintain the metal powder and the extractable material in their respective positions prior to sintering.

Description

CROSS REFERENCE TO RELATED APPLICATIONS[0001]The present application claims priority to U.S. Provisional App. No. 61 / 092,199, filed Aug. 27, 2008, the entire contents of which are hereby incorporated in their entirety.TECHNICAL FIELD[0002]The present invention pertains to, among other things, the preparation of mixtures that can be used for the production of porous metal constructs.BACKGROUND[0003]Porous metal constructs are widely used as, among other things, orthopedic implants, supports for catalysts, bone growth substrates, and filters. The “space holder” method is a well known process for making metallic foam structures and employs dissolvable or otherwise removable space-holding materials that are combined with metallic powders and subsequently removed from the combination by various methods, including heat evaporation or liquid dissolution, leaving behind a porous matrix formed from the metallic powder. The porous matrix material is then sintered to further strengthen the mat...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): B22F3/12B22F1/00B22F3/02
CPCA61L27/04A61L27/56C22C14/00B22F3/1121A61L2400/18
Inventor LIU, HENGDA D.SMITH, BRYANKING, RICHARD
Owner DEPUY PROD INC
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