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Retinol formulations and methods for their use

Inactive Publication Date: 2010-05-06
MILLSTEIN ELLIOTT
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

While retinoic acid is a highly effective therapeutic material, it can cause a number of undesirable side effects which include skin irritation and skin thinning among others.
This solubility problem has limited the use of retinol based formulations.
While emulsified preparations of retinol are known, it has been found that emulsified preparations of retinal have decreased efficacy when used as topical agents for the treatment of skin.
As a consequence, retinol based skin treatment formulations have been found to have limited utility, and hence the more risky retinoic acid based formulations are often used instead.

Method used

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Examples

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Embodiment Construction

[0010]The present invention recognizes that retinal can be a highly effective agent for the treatment of skin when it is applied thereto in a non-emulsified vehicle. Specifically, the present invention recognizes that retinol may be compounded into a suspension of fine droplets which are dispersed in an aqueous vehicle, and that this suspension will have enhanced utility as compared to emulsified preparations. This finding is counterintuitive and unexpected. Emulsified compositions are easy to prepare, and are considered in the art to be the optimum vehicle for delivering retinol to the skin. Suspensions are much more difficult to prepare than are emulsions. Furthermore, the prior art had no reason to expect that suspensions of retinol would be any more effective than emulsions as a topical treatment for skin. Hence, the prior art has never considered or employed suspensions of retinol for the treatment of skin conditions, and has not anticipated the enhanced therapeutic effect of t...

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Abstract

A composition for the treatment of skin comprises a non-emulsified, aqueous suspension of retinol. The composition may further include at least one protein species, and some proteins used in the composition include collagen and elastin. The composition may also include hyaluronic acid. The composition may also include one or more of tocopheryl acetate, propylene glycol, and linseed extract. Also disclosed are methods for making the composition and use of the composition for the treatment of skin.

Description

CROSS-REFERENCE TO RELATED APPLICATION[0001]This application claims priority of U.S. Provisional Patent Application Ser. No. 61 / 111,819 filed Nov. 6, 2008, entitled “Retinol Formulations and Methods for Their Use” which is incorporated herein by reference.FIELD OF THE INVENTION[0002]This invention relates to formulations and methods for the treatment of skin. More particularly the invention relates to formulations and methods wherein the active ingredient is a retinol. Most specifically the invention relates to formulations and methods based upon non-emulsified compositions of retinol wherein retinol is suspended in an aqueous vehicle.BACKGROUND OF THE INVENTION[0003]Retinoic acid is a very effective agent for the treatment of a variety of skin conditions including, but not limited to, acne, photo aging, wrinkles, and the like. One particular retinoic acid material used for skin treatment is tretinoin (all-trans retinoic acid). While retinoic acid is a highly effective therapeutic m...

Claims

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Application Information

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IPC IPC(8): A61K38/39A61K31/07A61P17/00A61K31/728
CPCA61K9/0014A61K31/07A61K38/39A61K47/42A61K2300/00A61K8/044A61K8/65A61K8/671A61K8/735A61Q19/00A61K8/64A61Q19/08A61K2800/5922A61P17/00
Inventor MILLSTEIN, ELLIOTT
Owner MILLSTEIN ELLIOTT
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