Modified antibody compositions, methods of making and using thereof

a technology of modified antibodies and compositions, applied in the field of modified antibody compositions, methods of making and, can solve the problem of reducing the ability of abs to bind its target, and achieve the effect of reducing the ability of abs to bind
US20100189651A1Inactive Publication Date: 2010-07-29CYTOMX THERAPEUTICS
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Patent Information

Authority / Receiving Office
US · United States
Current Assignee / Owner
CYTOMX THERAPEUTICS
Publication Date
2010-07-29
Estimated Expiration
Not applicable · inactive patent

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Abstract

The present disclosure provides modified antibodies which contain an antibody or antibody fragment (AB) modified with a masking moiety (MM). Such modified antibodies can be further coupled to a cleavable moiety (CM), resulting in activatable antibodies (AAs), wherein the CM is capable of being cleaved, reduced, photolysed, or otherwise modified. AAs can exhibit an activatable conformation such that the AB is more accessible to a target after, for example, removal of the MM by cleavage, reduction, or photolysis of the CM in the presence of an agent capable of cleaving, reducing, or photolysing the CM. The disclosure further provides methods of making and using such modified antibodies and activatable antibodies.
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Description

CROSS-REFERENCE

[0001] This application claims the benefit of U.S. Provisional Applications Nos. 61 / 144,110, filed Jan. 12, 2009; 61 / 144,105, filed Jan. 12, 2009; 61 / 249,441, filed Oct. 7, 2009; and 61 / 249,416, filed Oct. 7, 2009; which applications are incorporated herein by reference in their entirety.SEQUENCE LISTING

[0002] The instant application contains a Sequence Listing which has been submitted via EFS-Web and is hereby incorporated by reference in its entirety. Said ASCII copy, created on Apr. 1, 2010, is named 36383724.txt and is 218,125 bytes in size.BACKGROUND OF THE INVENTION

[0003] Protein-based therapies have changed the face of medicine, finding application in a variety of different diseases. In particular antibody-based therapies have proven effective treatments for some diseases but in some cases, toxicities due to broad target expression have limited their therapeutic effectiveness.

[0004] As with any drugs, however, the need and desire for drugs having improved specifici...

Claims

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