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Method for predicting a need for renal replacement therapy (RRT)

a technology of renal replacement therapy and prediction method, which is applied in the direction of measuring devices, microbiological testing/measurement, instruments, etc., can solve the problems of dialysis, no drug therapy available to counteract, and patients will require rr

Inactive Publication Date: 2011-06-09
ARGUTUS INTPROP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Currently no drug therapy is available for counteracting the effects of a reduction in kidney function as seen, for example in post CT surgery.
However, as indicated above, frequently, if such measures do not prove successful, the patient will require RRT, namely dialysis.

Method used

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  • Method for predicting a need for renal replacement therapy (RRT)
  • Method for predicting a need for renal replacement therapy (RRT)
  • Method for predicting a need for renal replacement therapy (RRT)

Examples

Experimental program
Comparison scheme
Effect test

example 1

Use of πGST as a Biomarker for AKI in Patients Undergoing CT Surgery

[0046]A retrospective study of 68 patients who had undergone elective CT surgery at the University of Chicago Hospital was carried out.

[0047]The patients were screened and approached for enrolment. The patients were excluded if they met any of the following criteria:

Pre-existing End Stage Renal Disease (ESRD) (on RRT) or Renal Transplant.

[0048]Age <18 years old.

Use of radiocontrast within 24 hours of surgery.

Change in thyroid hormone replacement dose in the last 2 weeks

Change in thyroid chronic corticosteroids dose in the last 2 weeks

Unstable renal function (ΔSerum Creatinine ≧0.2 mg / dl in the last 2 months of Oliguria defined as <400 ml / day).

[0049]Urine and blood samples were collected and stored.

[0050]The urine samples were tested for the presence of πGST using the aforementioned πGST EIA available from Biotrin International Limited (Catalogue Number BIO85).

[0051]Serum Creatinine (SCr) was measured using the Jaffé...

example 2

Use of πGST as a Biomarker for a Requirement for RRT Patients Undergoing CT Surgery

[0063]A study was carried out on the 68 patients, the subject of Example 1, using the same methodology for the detection of SCr and πGST.

[0064]Seven patients out of the 68 patients tested required RRT. The results are shown in Table 2.

TABLE 2BaselineCreatinineHours inCreatinineat RRTICU prior(mg / dL)(mg / dL)to RRTIndication15.035.425.3Refractory Hyperkalemia (6.0), Oliguria21.493.4851.2Anuria, Elevated creatinine, Shock1.36 post-op31.31.4221.6Volume overload, Hypoxia, Oliguria, Hemodynamic instability*AKI not diagnosed using current SCr measures*41.23.7926.8Lactic Acidosis Oliguria, Shock, Elevated creatinine50.991.283Lactic Acidosis Anuria, Shock,*AKI not diagnosed using current SCr measures*61.191.745.3Anuria, Shock (3 pressors), Volume overload. Acidosis71.662.881Volume overload, pulmonary edema. Shock

[0065]The time point at which patients requiring RRT would be first diagnosed is shown in Table 3.

TA...

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Abstract

A method for predicting a need for Renal Replacement Therapy (RRT) in a patient comprises: determining a concentration of pi glutathione S transferase-(πGST) in a first urine sample from the patient; and wherein a need for RRT is predicted when the πGST concentration is determined to be elevated in comparison to a patient without kidney injury. The method according to the invention can further comprise detecting for the presence of risk factors for RRT in a patient, the risk factors including elevated serum creatinine concentration, type I diabetes, type II diabetes, hypertension, dyslipidemia, hyperglycaemia, proteinuria and hypoalbuminemia.

Description

[0001]This application is a Divisional of copending application Ser. No. 12 / 076,410 filed on Mar. 18, 2008. The entire contents of all of the above applications are hereby incorporated by reference.TECHNICAL FIELD[0002]This invention relates to the early identification and prediction of kidney damage, including early identification and prediction of elevated blood creatinine levels resulting from a reduction in kidney function in a subject and, in particular, to biomarkers for the detection thereof.BACKGROUND ART[0003]There are many causes of a reduction in kidney function and it is essential that corrective action is taken as early as possible by appropriate medical intervention so as to minimise as far as possible the deleterious consequences, which include total renal failure and a need for dialysis and ultimately kidney transplant. For example, an abrupt reduction in kidney function occurs frequently following cardiothoracic (CT) surgery. Thus, Acute Kidney Injury (AKI) is commo...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): C12Q1/48G01N33/573
CPCG01N33/6893G01N2800/347G01N2333/91177
Inventor KILTY, CORMAC GERARDKOYNER, JAY LAWRENCEMCGRATH, CLAIRE VICTORIAMURRAY, PATRICK THOMASSCHUSTER, KERSTIN
Owner ARGUTUS INTPROP
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