Use of remote ischemic conditioning to improve outcome after myocardial infarction

a technology of ischemic conditioning and myocardial infarction, which is applied in the field of use of remote ischemic conditioning to improve outcome after myocardial infarction, can solve the problems of poor long-term prognosis, post-mi congestive heart failure reportedly at a 10-fold higher risk of death, and at risk of heart dysfunction/failure, so as to reduce the incidence, frequency and/or severity of symptoms associated with myocardial infarction

Inactive Publication Date: 2011-10-06
HOSPITAL FOR SICK CHILDREN
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Benefits of technology

[0004]Thus, in one aspect, the invention provides a method comprising performing a repeated RIC regimen on a subject during and/or after an MI. The method may be a method for improving the overall outcome of a subject following MI, including but not limited to reducing the risk of heart dysfunction/failure following an MI, reducing the incidence, frequency and/or severity of the symptoms associated with heart dysfunction/failure following an MI, and/or delaying the onset of heart dysfunction/fai

Problems solved by technology

Survivors of myocardial infarction (MI) are at significant risk of heart dysfunction/failure resulting from myocardial remodeling resulting from the MI.
This remodeling is as

Method used

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  • Use of remote ischemic conditioning to improve outcome after myocardial infarction
  • Use of remote ischemic conditioning to improve outcome after myocardial infarction
  • Use of remote ischemic conditioning to improve outcome after myocardial infarction

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Materials and Methods

[0137]Animals. Fifty eight week-old male Sprague-Dawly (SD) rats, weighing between 250 g and 280 g (Experimental Animal Center, Fudan University, Shanghai, P.R. China) were studied. The animal research study protocol was in compliance with ‘The Guide for the Care of Use of Laboratory Animals’ published by the National Institute of Health (NIH Publication No. 85-23, revised 1996) and approved by the Animal Care Committee of Shanghai Sixth Hospital, Shanghai Jiao Tong University School of Medicine. All the rats were housed for two weeks for an acclimatization period before the experiments.

[0138]Surgical Preparation. After anesthesia with sodium pentobarbital (40 mg / kg, IP) and endotracheal intubation, animals were ventilated (Animal Respirator DW-2000, Aloctt Biotech, Shanghai, P. R. China) with room air. The heart was exposed through a thoracotomy at the left fourth intercostal space. The left anterior descending coronary artery (LAD) was encircled by a 6-0 prole...

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Abstract

The invention provides methods for reducing the incidence and/or severity and/or delaying the onset of heart dysfunction/failure and improving overall survival through the use of remote ischemic per-conditioning and post-conditioning.

Description

RELATED APPLICATIONS[0001]This application claims the benefit of U.S. Provisional Application Ser. No. 61 / 319,597, filed on Mar. 31, 2010, entitled “USE OF REMOTE ISCHEMIC CONDITIONING TO REDUCE HEART DYSFUNCTION AND / OR HEART FAILURE AFTER MYOCARDIAL INFARCTION”, the entire contents of which are incorporated by reference herein.BACKGROUND OF THE INVENTION[0002]Survivors of myocardial infarction (MI) are at significant risk of heart dysfunction / failure resulting from myocardial remodeling resulting from the MI. This remodeling is associated with poor long-term prognosis, with patients with post-MI congestive heart failure reportedly at a 10-fold higher risk of death as shown in a 5 year follow up study. Treatment of myocardial infarction has concentrated on reducing the period of ischemia and minimizing injury that occurs during post-ischemic reperfusion. Thus, many therapies have aimed to reduce the size of the heart infarct as much as possible or to prevent its occurrence altogethe...

Claims

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Application Information

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IPC IPC(8): A61B17/00
CPCA61B17/1327A61B2017/00199A61B17/1355A61K31/165A61K31/401A61K31/4178A61K31/4184A61P9/04A61P9/10A61B17/12009A61K31/00A61B2017/00544
Inventor REDINGTON, ANDREW
Owner HOSPITAL FOR SICK CHILDREN
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