Methods for treating tweak-related conditions

a technology of tweak expression and agent, applied in the direction of peptide/protein ingredients, depsipeptides, fusion polypeptides, etc., can solve the problems of inability to efficiently deliver a death signal and lack of complete understanding of what conditions or diseases are related to tweak expression and function, and achieve the effect of promoting tissue regeneration and replacemen
US20120015024A1Inactive Publication Date: 2012-01-19BIOGEN MA INC
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Patent Information

Authority / Receiving Office
US · United States
Patent Type
Applications(United States)
Current Assignee / Owner
BIOGEN MA INC
Publication Date
2012-01-19
Estimated Expiration
Not applicable · inactive patent

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Abstract

The present invention provides methods and agents for the treatment of TWEAK-related conditions, including cardiac, liver, kidney, lung, adipose, skeletal, muscle, neuronal, bone and cartilage conditions. The invention also provides methods for identifying TWEAK agonists or antagonists for the treatment of TWEAK-related conditions. Additionally, the invention provides transgenic animals that express an exogenous DNA encoding a TWEAK polypeptide, or fragments, analogs, or muteins thereof, and methods for using such animals to identify TWEAK agonists or antagonists. The invention further provides methods for diagnosing a disease based on TWEAK expression. The invention also provides methods for affecting cellular differentiation of progenitor cells using TWEAK polypeptides, agonists, or antagonists.
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Description

TECHNICAL FIELD OF THE INVENTION

[0001] The present invention relates to methods and agents for the treatment of TWEAK-related conditions, including cardiac, liver, kidney, lung, adipose, skeletal muscle, neural, bone, cartilage, skin, gastrointestinal, pancreatic, reproductive organ and connective tissue diseases. The invention also relates to methods for identifying TWEAK agonists or antagonists for the treatment of TWEAK-related conditions. Additionally, the invention relates to transgenic animals that express an exogenous DNA encoding a TWEAK polypeptide, or fragments, analogs, or muteins thereof and methods for using such animals to identify TWEAK agonists or antagonists. The invention further relates to methods for diagnosing a disease based on TWEAK expression. The invention also relates to methods for affecting cellular proliferation or differentiation of progenitor cells using TWEAK polypeptides, agonists or antagonists.BACKGROUND OF THE INVENTION

[0002] Members of the Tumor Ne...

Claims

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