Compositions for treating nervous system conditions

Abstract

Compositions for treating nervous system conditions. In at least one embodiment of a stem cell conditioned medium of the present disclosure, the stem cell comprises a cell culture supernatant containing at least one factor capable of exerting effective neuroprotection to treat a mammalian neural injury or insult, the cell culture supernatant produced by culturing at least one mammalian adipose stem cell to produce the at least one factor.

Description

PRIORITY[0001]The present application is related to, claims the priority benefit of, and is a U.S. continuation application of, U.S. Nonprovisional patent application Ser. No. 11 / 844,941, filed Aug. 24, 2007 and issued as U.S. Pat. No. 8,021,882 on Sep. 20, 2011, which is related to, and claims the priority benefit of, U.S. Provisional Patent Application Ser. No. 60 / 823,460, filed August 24, 2006. The contents of each of these applications are hereby incorporated by reference in their entirety into this disclosure.BACKGROUND[0002]Pluripotent cells, sometimes referred to as stem cells, are characterized by an ability to differentiate into a variety of different cells. Some pluripotent cells types, such as human embryonic stem cells, display an ability to differentiate into the broadest spectrum of cells; in fact, embryonic stem cells display an ability to differentiate into practically any type of cell that exists within the human tissues. However, as embryonic stem cells develop and...

AI Technical Summary

Benefits of technology

"The present patent provides a method for harvesting adipose stem cells (ASCs) from adipose tissue and using them for various therapeutic purposes. These cells can be obtained in large quantities and are a feasible and attractive source of pluripotent cells for harvest. The cells can be maintained and grown in cell culture, and they can produce bioactive proteins that promote neural cell survival and differentiation. The patent also describes the use of conditioned media from cultured ASCs to protect against neural cell death and to promote cell growth and differentiation. The stem cells can be used to treat neural tissue damage and insults, as well as to modulate physiological processes in the central nervous system. The patent also provides a method for concentrating and fractionating the stem cell conditioned media for further use. Overall, the patent provides a reliable and effective way to utilize adipose stem cells for therapeutic purposes."

Problems solved by technology

However, embryonic stem cells have limitations in their ability to be used clinically, as they must be derived from another individual—an embryo.

This not only raises a potential that the patient will reject the cells, but it also severely limits the ability for such cells to be used in the first place.

Therefore, much effort has been made in finding pluripotent cells that are obtainable in large quantities, that can differentiate into a target cell, and that will not be rejected by the individual being treated thereby.

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