Diagnosis and treatment of multiple sulfatase deficiency and other sulfatase deficiencies

a technology of sulfatase and deficiency, applied in the direction of enzymology, drug composition, metabolic disorders, etc., can solve the problems of hampered efforts to identify this gene(s) and achieve the effect of increasing the c-formylglycine generating activity
US20130028881A1Inactive Publication Date: 2013-01-31SHIRE HUMAN GENETIC THERAPIES INC
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Patent Information

Authority / Receiving Office
US · United States
Patent Type
Applications(United States)
Current Assignee / Owner
SHIRE HUMAN GENETIC THERAPIES INC
Publication Date
2013-01-31
Estimated Expiration
Not applicable · inactive patent

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Abstract

This invention relates to methods and compositions for the diagnosis and treatment of Multiple Sulfatase Deficiency (MSD) as well as other sulfatase deficiencies. More specifically, the invention relates to isolated molecules that modulate post-translational modifications on sulfatases. Such modifications are essential for proper sulfatase function.
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Description

RELATED APPLICATIONS

[0001] This application is a continuation of prior filed, co-pending application Ser. No. 10 / 775,678, filed Feb. 10, 2004, which claims priority under 35 U.S.C. §119(e) from Provisional U.S. Patent Application Ser. No. 60 / 447,747, filed Feb. 11, 2003, and entitled DIAGNOSIS AND TREATMENT OF MULTIPLE SULFATASE DEFICIENCY AND OTHER SULFATASE DEFICIENCIES. The contents of each application are hereby expressly incorporated by reference.FIELD OF THE INVENTION

[0002] This invention relates to methods and compositions for the diagnosis and treatment of Multiple Sulfatase Deficiency (MSD) as well as other sulfatase deficiencies. More specifically, the invention relates to isolated molecules that modulate post-translational modifications on sulfatases. Such modifications are essential for proper sulfatase function.BACKGROUND OF THE INVENTION

[0003] Sulfatases are members of a highly conserved gene family, sharing extensive sequence homology (Franco, B., et al., Cell, 1995, 81:...

Claims

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