Methods Useful in Optimizing the Treatment of Neuropathies and Targeting Tissues with Cosmetic Botulinum Injections

a neuropathology and botulinum injection technology, applied in the field of cosmetic treatments, can solve the problems of facial musculature, many invasive techniques, and inability to objectively quantify the direct effect, and achieve the effects of improving the current standard of care for cosmetic treatments, small improvement, and difficult detection

a neuropathology and botulinum injection technology, applied in the field of cosmetic treatments, can solve the problems of facial musculature, many invasive techniques, and inability to objectively quantify the direct effect, and achieve the effects of improving the current standard of care for cosmetic treatments, small improvement, and difficult detection

US20130123647A1Inactive Publication Date: 2013-05-16THE RESAERCH FOUND FOR THE STATE UNIV O
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  • Methods Useful in Optimizing the Treatment of Neuropathies and Targeting Tissues with Cosmetic Botulinum Injections
  • Methods Useful in Optimizing the Treatment of Neuropathies and Targeting Tissues with Cosmetic Botulinum Injections
  • Methods Useful in Optimizing the Treatment of Neuropathies and Targeting Tissues with Cosmetic Botulinum Injections

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[0026]Examples of data generated from the present methods are shown in FIGS. 2-7. In addition, the following work has been conducted.

[0027]As noted above, DISC is based on following the deformation of a correlated set of speckles and generates an essentially complete mapping of the deformation of the skin pores, thereby determining the loci where stress is applied to the skin and the specific combination of muscles involved in a particular motion. Botulinum Toxin (BT) has a number of clinical applications, including cosmetic treatment of facial lines. (In the description above, we have referred to the widely used formulation of BT marketed as BOTOX®, however it is to be understood that any cosmetically acceptable agent that similarly induces paralysis could be used and analyzed by the present methods in the same manner.) Previously, the degree and duration of effects on the muscles of facial expression have been evaluated using qualitative subjective measurements (Carruthers and Car...

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Abstract

The present invention pertains to methods of determining where, on the skin, a diagnostic, therapeutic, or cosmetic agent is likely to be most effectively applied (e.g., injected), and to methods for monitoring a patient after such an agent has been administered. The monitoring can produce information useful in determining whether a diagnostic, therapeutic (e.g., surgical), or cosmetic regime should be initiated, continued, continued in a modified fashion, or terminated (e.g., for a brief or prolonged period of time). The methods can be repeated periodically and use a non-invasive, in vivo form of digital image speckle correlation (DISC) to track deformation of the skin.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS[0001]This application claims the benefit of the filing date of U.S. Application No. 61 / 482,057, which was filed May 3, 2011. The content of this earlier-filed provisional application is hereby incorporated by reference herein in its entirety.STATEMENT REGARDING FEDERALLY FUNDED RESEARCH[0002]This invention was made with government support under grant number DMR0606387 awarded by the National Science Foundation. The government has certain rights in the invention.FIELD OF THE INVENTION[0003]The present invention relates to both cosmetic treatments and to more serious conditions, including neuropathies (e.g., those caused by an acoustic neuroma) and stroke. More specifically, the invention relates to methods of optimizing where cosmetic agents such as botulinum toxin are best applied (e.g., injected); to methods of determining when and where treatment, including surgical intervention, for neuropathies should be undertaken; and to methods of evalu...

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Application Information

Patent Timeline
16 May 2013
Publication
US20130123647A1
IPC
A61B5/00
CPC
A61B5/442; A61B5/1107; A61B5/4839; A61B5/4041; A61B5/1128
Inventors
BHATNAGAR, DIVYA; RAFAILOVICH, MIRIAM