Enhanced Delivery of Nicotine, THC, Tobacco, Cannabidiol or Base Alkaloid from an Electronic Cigarette or Other Vapor or Smoke Producing Device Through Use of an Absorption Conditioning Unit

a technology of absorption conditioning unit and enhanced delivery, which is applied in the direction of tobacco treatment, inorganic non-active ingredients, tobacco, etc., can solve the problem that electronic cigarettes fail to deliver a steeply peaked blood plasma delivery of nicotine like

Inactive Publication Date: 2014-06-19
FUISZ RICHARD C +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0009]In another aspect of the present invention, an absorption conditioning unit, includes a dosage form including at least at least one material that creates a pH in the oral cavity of 7.8-10 for a period of ten minutes or more after administration, the dosage form not containing an acid and not containing a drug.

Problems solved by technology

Despite this rapid sales growth, it is understood that electronic cigarettes fail to deliver a steeply peaked blood plasma delivery of nicotine like the conventional cigarette does.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example a

Soft Lozenge

[0089]A soft lozenge was made comprising 300 mg of sodium bicarbonate together with carbowax sentry PEG 1450. The resulting lozenge weighted approximately one gram, had harmless taste and was easily chewable.

[0090]The lozenge of this example was provided to a healthy female volunteer, and the pH of her saliva was measured at intervals over a period of ten minutes.

[0091]The t0 saliva pH was 6.8; t1 was 8.3; t3 was 8.3; t5 was 8.3 and t10 was 8.1.

[0092]For this and the other examples, pH measurements were taken using a Horiba compact portable meter.

example b

Liquid and Nicotine Delivery

[0093]A healthy male volunteer experienced with nicotine placed approximately 400 mg of sodium bicarbonate in a hot tea cup, and stirred the liquid.

[0094]The volunteer took several strong draws on a commercially available Nicotrol® inhaler (10 mg / cartridge, marketed by Pfizer). The volunteer noted a mild throat burn sensation—attributable to nicotine absorption.

[0095]The volunteer then took three sips of the hot beverage, and used the same Nicotrol® inhaler again. The volunteer noted a burn sensation throughout the mouth including the roof of the mouth. The user noted the sensation was comparable to the throat sensation. The user felt the nicotine delivery was much stronger.

[0096]The same health male volunteer repeated the same experiment this time, except that a tobacco-based e-cigarette from Discreet®. The volunteer noted a similar improvement in nicotine delivery.

[0097]This same experiment was repeated with room temperature water (and Nicotrol®) While ...

example c

Liquid

[0098]A liquid was prepared by adding the following ingredients in the following order: Sodium bicarbonate (NaHCO3) 3.35 g; tablet salt 0.315 g; tap water 16.11 g; and glycerin 11.38 g of glycerin.

[0099]The liquid of this example was provided to a healthy female volunteer (one ½ teaspoon was swirled in the mouth without swallowing), and the pH of her saliva was measured at intervals over a period of ten minutes.

[0100]The T0 pH was 6.5; T1 was 8.5; T3 was 8.7; T4 was 8.2; T8 was 7.5 and T10 was 7.6.

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PUM

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Abstract

A method for the administration of nicotine, THC, tobacco, cannabidiol or a base alkaloid includes administering in the oral or nasal cavity an absorption conditioning unit having at least two agents selected from the group consisting of (a) a buffer agent, (b) a capturing agent, (c) a penetration agent, and (d) a thermal agent, to the mammal, and then administering by inhalation a bioactive agent selected from the group consisting of nicotine, THC, cannabidiol and a base alkaloid. The absorption conditioning unit may be in a dosage form not containing a drug. The absorption conditioning unit may create a pH in the oral cavity or nasal cavity of 7.8-10 for a period of ten minutes or more after administration, the dosage form not containing an acid and not containing a drug.

Description

BACKGROUND[0001]Electronic vapor devices are increasingly popular with consumers. Such devices comprise electronic cigarettes, electronic pipes, electronic hookahs, personal vaporizers and other inhalator embodiments, both electronic and mechanical.[0002]UBS estimates that US e-cigarette sales will reach $500 million by the end of 2012, representing 100% growth from the preceding year (See UBS Tobacco Analyst Nik Modi's May 14, 2012 report entitled “Clearing the Smoke on E-Cigarettes,” the entirety of which is incorporated herein by reference). Arguably, the most well-respected tobacco analyst, Bonnie Herzog of Wells Fargo, has gone so far as to suggest in discussing Lorillard: “We remain very encouraged by blu [Lorillard's e-cigarette brand] and see huge upside potential given our belief ecigs could overtake traditional cigarettes in 10 years.” See Wells Fargo Lorillard Equity Research dated Oct. 24, 2012, the entirely of which is incorporated herein by reference. British American ...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A24F47/00A24D1/00A24F40/10
CPCA61K9/0043A61K47/02A61K9/006A24F40/10A24D1/002
Inventor FUISZ, RICHARD C.FUISZ, JOSEPH M.
Owner FUISZ RICHARD C
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